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The map label for this gene is gcvT

Identifier: 78064802

GI number: 78064802

Start: 172392

End: 173510

Strand: Reverse

Name: gcvT

Synonym: Bcep18194_A3325

Alternate gene names: 78064802

Gene position: 173510-172392 (Counterclockwise)

Preceding gene: 78064803

Following gene: 78064801

Centisome position: 4.7

GC content: 67.29

Gene sequence:

>1119_bases
ATGACTGCACTGAATCACACCCCGCTCAACGCCGCGCACCGCGCGCTCAATGCCCGCATGGTCGACTTCGGCGGCTGGGA
CATGCCCGTCAACTACGGCTCGCAGATCGAAGAGCATGAAGCCGTGCGCACCGACGCCGGCATGTTCGACGTGTCGCACA
TGTGCGTGGTCGATTTCACCGGCAGCCGCGTGCGCGCGTTCTTCGAGCACGCGATCGCGAACAACGTCGGCAAGCTCAAG
ACGCCCGGCAAGGCCCTCTACTCGTGCCTGCTCAATCCGCAGGGCGGCGTCATCGACGACCTGATCGTCTACTACTTCAC
CGAGGAATTCTTCCGCGTCGTCGTCAACGCCGGCACGGCCGAGAAAGACATCGCGTGGTTCAACCAGCTGAACGAGCAAG
GCGGCTTCGGCGTCACGATCACGCCGCGCCGCGATTTCGCGATCGTCGCCGTACAGGGCCCGAACGCCCGCGAAAAAGCG
TGGTCGACGGTGCCCGCCGCGCGCGCCGCCACCAGCGAACTGAAGCCGTTCAACGCCGCGCAGGTCGCCGGCACGCCGTT
CGGCGATCTCACCGTCGCGCGCACCGGCTACACCGGTGAAGACGGTTTCGAAGTGATCGTCCCGGCCGTGCACGTCGAAG
CGCTGTGGAACGCGCTGCAGCAAAACGGCGTGCGCCCGTGCGGGCTCGGCGCGCGCGACACGCTGCGCCTCGAGGCCGGC
ATGAACCTGTACGGCCAGGACATGGACGACACCGTGTCGCCGCTCGACGCGGGCCTCGCGTGGACGGTCGACCTTACCGC
GCCGCGCGACTTCGTCGGCCGCGCCGCACTGGAAGCCAACGGCACCCGCGCCGCATTCGTCGGCCTGATCCTGCAGAAGG
AAAACGGCAAGGCCGGCGGCGTGCTGCGCGCGCACCAGAAGGTCGTCACGCCGCACGGCGAAGGCGAGATCACGAGCGGC
ACGTTCTCGCCGTCGATGCAGGAATCGATCGCGTTCGCGCGCGTGCCGGCGGCCGTCCAGATCGGCGACCTGGTCCAGGT
GCAAATTCGCGACAAGAATCTTCCCGCGCGCGTGGTAAAACTGCCGTTCGTGCGCAACGGCAAGGTCCTCGCTGCGTAA

Upstream 100 bases:

>100_bases
GGACAGAGGGGCATGTACCGGATCGCTCGCAGGCCGTTGGCCGCGGTGGTCGGCACATGGCCGTTCTGATCCGCGCGCAA
GCGCCTTGCCTGAGGCCTCG

Downstream 100 bases:

>100_bases
CGGCCGGGAGGCCCGCCTCCCGGGAAGCCGGGAGATGGCGCCCGGCGCAACACCACACCCGGCGCGCCCCGGCGGCGCGT
CAGCAAAACGAATAAACCCT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTALNHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRVRAFFEHAIANNVGKLK
TPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGVTITPRRDFAIVAVQGPNAREKA
WSTVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQNGVRPCGLGARDTLRLEAG
MNLYGQDMDDTVSPLDAGLAWTVDLTAPRDFVGRAALEANGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSG
TFSPSMQESIAFARVPAAVQIGDLVQVQIRDKNLPARVVKLPFVRNGKVLAA

Sequences:

>Translated_372_residues
MTALNHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRVRAFFEHAIANNVGKLK
TPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGVTITPRRDFAIVAVQGPNAREKA
WSTVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQNGVRPCGLGARDTLRLEAG
MNLYGQDMDDTVSPLDAGLAWTVDLTAPRDFVGRAALEANGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSG
TFSPSMQESIAFARVPAAVQIGDLVQVQIRDKNLPARVVKLPFVRNGKVLAA
>Mature_371_residues
TALNHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRVRAFFEHAIANNVGKLKT
PGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGVTITPRRDFAIVAVQGPNAREKAW
STVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQNGVRPCGLGARDTLRLEAGM
NLYGQDMDDTVSPLDAGLAWTVDLTAPRDFVGRAALEANGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSGT
FSPSMQESIAFARVPAAVQIGDLVQVQIRDKNLPARVVKLPFVRNGKVLAA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=35.4497354497354, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI257796258, Length=350, Percent_Identity=35.4285714285714, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=34.6875, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI257796254, Length=373, Percent_Identity=31.0991957104558, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI24797151, Length=340, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI197927446, Length=349, Percent_Identity=24.0687679083095, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI21361378, Length=349, Percent_Identity=24.0687679083095, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789272, Length=377, Percent_Identity=54.1114058355438, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17560118, Length=383, Percent_Identity=33.420365535248, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71994052, Length=348, Percent_Identity=23.5632183908046, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=348, Percent_Identity=23.5632183908046, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=33.1592689295039, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129441, Length=381, Percent_Identity=33.0708661417323, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28571104, Length=278, Percent_Identity=25.1798561151079, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20130091, Length=303, Percent_Identity=26.0726072607261, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40003; Mature: 39872

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALNHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFT
CCCCCCCCCHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEECCEEEEEEEC
GSRVRAFFEHAIANNVGKLKTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTA
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
EKDIAWFNQLNEQGGFGVTITPRRDFAIVAVQGPNAREKAWSTVPAARAATSELKPFNAA
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHCCCCCCH
QVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQNGVRPCGLGARDTLRLEAG
HCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
MNLYGQDMDDTVSPLDAGLAWTVDLTAPRDFVGRAALEANGTRAAFVGLILQKENGKAGG
CCCCCCCCCHHHHHHCCCEEEEEEECCCHHHHCCHHCCCCCCEEEEEEEEEECCCCCCCC
VLRAHQKVVTPHGEGEITSGTFSPSMQESIAFARVPAAVQIGDLVQVQIRDKNLPARVVK
EEEECCEEECCCCCCCEECCCCCCCHHHHHHHHHCCCEEEECCEEEEEEECCCCCEEEEE
LPFVRNGKVLAA
ECEEECCCEEEC
>Mature Secondary Structure 
TALNHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFT
CCCCCCCCHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEECCEEEEEEEC
GSRVRAFFEHAIANNVGKLKTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTA
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
EKDIAWFNQLNEQGGFGVTITPRRDFAIVAVQGPNAREKAWSTVPAARAATSELKPFNAA
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHCCCCCCH
QVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQNGVRPCGLGARDTLRLEAG
HCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
MNLYGQDMDDTVSPLDAGLAWTVDLTAPRDFVGRAALEANGTRAAFVGLILQKENGKAGG
CCCCCCCCCHHHHHHCCCEEEEEEECCCHHHHCCHHCCCCCCEEEEEEEEEECCCCCCCC
VLRAHQKVVTPHGEGEITSGTFSPSMQESIAFARVPAAVQIGDLVQVQIRDKNLPARVVK
EEEECCEEECCCCCCCEECCCCCCCHHHHHHHHHCCCEEEECCEEEEEEECCCCCEEEEE
LPFVRNGKVLAA
ECEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA