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The map label for this gene is gyrB

Identifier: 78064661

GI number: 78064661

Start: 3121

End: 5595

Strand: Direct

Name: gyrB

Synonym: Bcep18194_A3184

Alternate gene names: 78064661

Gene position: 3121-5595 (Clockwise)

Preceding gene: 78064660

Following gene: 78064662

Centisome position: 0.08

GC content: 61.37

Gene sequence:

>2475_bases
ATGAGTGAACAGCACAATCCGCAACCCGATAACAGCAGCTACGGCGCTTCGTCGATCCAGATCCTCGAAGGTCTGGAAGC
GGTGCGCAAGCGCCCCGGGATGTACATCGGCGACACGTCGGACGGCACCGGTCTGCATCACCTCGTGTTCGAGGTGCTCG
ACAACTCGATCGACGAAGCGTTGGCCGGGTACTGCAACGACATCCACGTAACGATTCACGCCGACAACTCGATTTCCGTG
ACCGACAACGGTCGCGGGATTCCGACCGACGTGAAGATGAACGACAAGCACGAGCCGAAGCGTAGCGCCGCGGAAATCGT
GATGACCGAGCTGCATGCCGGCGGCAAGTTCGACCAGAACAGCTACAAGGTGTCCGGTGGCCTGCACGGCGTGGGTGTGT
CGTGCGTGAACGCGCTGTCGAGCTGGCTGCGCCTCACGGTGCGCCGTGACGGCAAGAAGCGGTTCATGGAGTTCCATCGC
GGCGTCGCGCAGGATCGCGTGCTCGAGATGGTGGATGGTGTCGAAGTGTCGCCGATGCTGGTAACCGGTGACACCGAGAA
CCGCGGCACCGAAGTGCACTTCATGGCCGATCCGACGATTTTCGGCACGGTCGAGTATCACTACGACATCCTCGCGAAGC
GGATGCGCGAGCTTTCGTTCCTGAACAACGGTGTGCGGATTCGCCTCACCGATCTGCGTTCGGGCAAGGAAGACGATTTC
GCGTTCGCCGGCGGTGTGAAGGGCTTCGTCGAGTTCATCAACAAGACGAAGACCAACCTGCACCCGACGGTGTTCTTCGC
CACCGGCGAGAAGGATGGCGTGGGCGTCGAAGTCGCGATGCAGTGGAACGACAGCTACAACGAAAACGTGCTGTGCTTCA
CGAACAACATTCCGCAGCGCGACGGCGGCACGCACCTGACCGGCCTGCGGGCCGCGATGACGCGCGTCATCAACAAGTAC
ATCACCGACAACGAAATCGCGAAGAAGGCGAAGGTCGAAACGACCGGCGACGACATGCGCGAAGGGCTGTCGTGCGTGCT
TTCCGTGAAGGTGCCGGAGCCGAAGTTCAGCTCGCAGACGAAGGACAAGCTGGTTTCTTCCGAGGTTCGCGCGCCGGTTG
AAGAAGTTGTGGCGAAGGCGCTGGAAGAGTTCCTTTTGGAAACGCCGATCGACGCGAAGATCATCTGCGGGAAGATCGTC
GAAGCTGCTCGGGCGCGTGATGCGGCTCGGAAGGCGCGTGAAATGACGCGCCGCAAGGGCGTGCTCGACGGCGTCGGCCT
GCCCGGTAAGCTCGCGGACTGCCAGGAGAAAGACCCGGCGAAGTGCGAAATCTACATCGTCGAGGGTGACTCGGCAGGTG
GGTCGGCCAAGCAAGGGCGTGACCGGAAGTTCCAGGCGATCCTGCCGCTGCGCGGCAAGGTGCTGAACGTGGAGAAGGCG
CGCTACGACAAGCTGCTGTCGTCGGAACAGATCGTCACGCTCGTGACCGCGCTCGGCTGCGGCATCGGCAAGGAAGACTA
CAACCTCGACAAGCTCCGCTATCACCGCATCATCATCATGACCGACGCGGACGTCGACGGCGCACACATCCGGACGCTGC
TGCTCACGTTCCTCTATCGCCAGATGCCGGACATGATCGAGCGTGGGTATGTATATATCGCGCAGCCGCCGCTTTACAAG
ATCAAGGCGGGTAAGGACGAGCGGTATCTGAAGGATGACGTGGAGCTCAACGCGCATATGCTGCGGTTGGCGCTGCAAGG
GTCGGAGCTGGTGCCGGGTGAGAACGCGGCCGTGATTTCGGGCGATGCGCTTGGAGAGCTGGCGCGGTCGTATCTGCTGT
CGAAGAGCGTGATCGAGCGGTTGAGCCGGTTGTATGACCCGGCGGCGCTTGAGGCGATCATGGACGGGGTGGTGATCGAT
CTGTCCAACGAGGCTTCTACGGAGGCTTCGGCTAAGGCGCTACACGCTGCGTTGCATGACGAGGCGTTGAAGAACGAAGT
GCGCGTGGTGCCTTCGTATGACCCGGTTCGCGAACAACGGTCGCTGCATGTCGAACGTACGCATCACGGCAACGTGCGGG
TTTCGGTCATCGACCAGGAATTCCAGCACACGGCGGATTATCAGCAGCTCGTGACCACCGCGAATACGTTCAAGGGGCTC
ATCGGGGAAGGTGCGGTCATCAAGCGTGGTGAGCGCAGCATGGCGGTGACGGACTTCAAGAGCGCGATGAAGTGGCTGCT
GGCGGATGCGGAGCGGAACGTTTCGAAGCAGCGGTATAAGGGGCTCGGCGAGATGAACCCCGGGCAGCTGTGGGAAACGA
CGATGGATCCGGCGGTGCGGCGACTGCTGCGCGTGCAGATCGAAGACGCGATTGCTGCGGATGGGATCTTTACCACCCTC
ATGGGGGATGATGTGGAGCCGCGGCGGGCGTTTATCGAGTCGAATGCGTTGCGGGCGGGGAATATTGACGTTTAA

Upstream 100 bases:

>100_bases
GTGCCTTGGACGGGCCAGGAAAACTGGAGCGGCCCGGCGTTTTCGCAAGGAAACGCACCATGCCGCCGCTTGAGTGGCCT
CGCAGAACCGGAAGATATCC

Downstream 100 bases:

>100_bases
CACCGCCTGACGTGCAGGGTGAGACTGGAGCCAAGTTCTTGAGACTGAAGCGGCAGAATTGATGAGACTGCCGGGATTAA
CGTCCCGGCAGGATCAGCGA

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MSEQHNPQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISV
TDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKRFMEFHR
GVAQDRVLEMVDGVEVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
AFAGGVKGFVEFINKTKTNLHPTVFFATGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKY
ITDNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPIDAKIICGKIV
EAARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKCEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
RYDKLLSSEQIVTLVTALGCGIGKEDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFLYRQMPDMIERGYVYIAQPPLYK
IKAGKDERYLKDDVELNAHMLRLALQGSELVPGENAAVISGDALGELARSYLLSKSVIERLSRLYDPAALEAIMDGVVID
LSNEASTEASAKALHAALHDEALKNEVRVVPSYDPVREQRSLHVERTHHGNVRVSVIDQEFQHTADYQQLVTTANTFKGL
IGEGAVIKRGERSMAVTDFKSAMKWLLADAERNVSKQRYKGLGEMNPGQLWETTMDPAVRRLLRVQIEDAIAADGIFTTL
MGDDVEPRRAFIESNALRAGNIDV

Sequences:

>Translated_824_residues
MSEQHNPQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISV
TDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKRFMEFHR
GVAQDRVLEMVDGVEVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
AFAGGVKGFVEFINKTKTNLHPTVFFATGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKY
ITDNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPIDAKIICGKIV
EAARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKCEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
RYDKLLSSEQIVTLVTALGCGIGKEDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFLYRQMPDMIERGYVYIAQPPLYK
IKAGKDERYLKDDVELNAHMLRLALQGSELVPGENAAVISGDALGELARSYLLSKSVIERLSRLYDPAALEAIMDGVVID
LSNEASTEASAKALHAALHDEALKNEVRVVPSYDPVREQRSLHVERTHHGNVRVSVIDQEFQHTADYQQLVTTANTFKGL
IGEGAVIKRGERSMAVTDFKSAMKWLLADAERNVSKQRYKGLGEMNPGQLWETTMDPAVRRLLRVQIEDAIAADGIFTTL
MGDDVEPRRAFIESNALRAGNIDV
>Mature_823_residues
SEQHNPQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVT
DNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKRFMEFHRG
VAQDRVLEMVDGVEVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDFA
FAGGVKGFVEFINKTKTNLHPTVFFATGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYI
TDNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPIDAKIICGKIVE
AARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKCEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
YDKLLSSEQIVTLVTALGCGIGKEDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFLYRQMPDMIERGYVYIAQPPLYKI
KAGKDERYLKDDVELNAHMLRLALQGSELVPGENAAVISGDALGELARSYLLSKSVIERLSRLYDPAALEAIMDGVVIDL
SNEASTEASAKALHAALHDEALKNEVRVVPSYDPVREQRSLHVERTHHGNVRVSVIDQEFQHTADYQQLVTTANTFKGLI
GEGAVIKRGERSMAVTDFKSAMKWLLADAERNVSKQRYKGLGEMNPGQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLM
GDDVEPRRAFIESNALRAGNIDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=550, Percent_Identity=24.5454545454545, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI19913408, Length=560, Percent_Identity=24.8214285714286, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI48994957, Length=826, Percent_Identity=58.5956416464891, Blast_Score=946, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=559, Percent_Identity=37.7459749552773, Blast_Score=356, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17535065, Length=602, Percent_Identity=23.7541528239203, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=523, Percent_Identity=24.282982791587, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=159, Percent_Identity=28.9308176100629, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=612, Percent_Identity=24.5098039215686, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17136538, Length=554, Percent_Identity=23.4657039711191, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91143; Mature: 91012

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQHNPQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LAGYCNDIHVTIHADNSISVTDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQN
HHHCCCEEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAQDRVLEMVDGVEVSPML
CEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHCCCCCCEEE
VTGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
EECCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
AFAGGVKGFVEFINKTKTNLHPTVFFATGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQR
EECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCC
DGGTHLTGLRAAMTRVINKYITDNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQT
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHCCEEEEEEECCCCCCCCHH
KDKLVSSEVRAPVEEVVAKALEEFLLETPIDAKIICGKIVEAARARDAARKAREMTRRKG
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLDGVGLPGKLADCQEKDPAKCEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEECHHH
RYDKLLSSEQIVTLVTALGCGIGKEDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFLYR
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
QMPDMIERGYVYIAQPPLYKIKAGKDERYLKDDVELNAHMLRLALQGSELVPGENAAVIS
HHHHHHHCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEE
GDALGELARSYLLSKSVIERLSRLYDPAALEAIMDGVVIDLSNEASTEASAKALHAALHD
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHH
EALKNEVRVVPSYDPVREQRSLHVERTHHGNVRVSVIDQEFQHTADYQQLVTTANTFKGL
HHHHCCEEECCCCCCHHHHHCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
IGEGAVIKRGERSMAVTDFKSAMKWLLADAERNVSKQRYKGLGEMNPGQLWETTMDPAVR
HCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
RLLRVQIEDAIAADGIFTTLMGDDVEPRRAFIESNALRAGNIDV
HHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SEQHNPQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LAGYCNDIHVTIHADNSISVTDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQN
HHHCCCEEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SYKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAQDRVLEMVDGVEVSPML
CEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHCCCCCCEEE
VTGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
EECCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
AFAGGVKGFVEFINKTKTNLHPTVFFATGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQR
EECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCC
DGGTHLTGLRAAMTRVINKYITDNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQT
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHCCEEEEEEECCCCCCCCHH
KDKLVSSEVRAPVEEVVAKALEEFLLETPIDAKIICGKIVEAARARDAARKAREMTRRKG
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLDGVGLPGKLADCQEKDPAKCEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEECHHH
RYDKLLSSEQIVTLVTALGCGIGKEDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFLYR
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
QMPDMIERGYVYIAQPPLYKIKAGKDERYLKDDVELNAHMLRLALQGSELVPGENAAVIS
HHHHHHHCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEE
GDALGELARSYLLSKSVIERLSRLYDPAALEAIMDGVVIDLSNEASTEASAKALHAALHD
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHH
EALKNEVRVVPSYDPVREQRSLHVERTHHGNVRVSVIDQEFQHTADYQQLVTTANTFKGL
HHHHCCEEECCCCCCHHHHHCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
IGEGAVIKRGERSMAVTDFKSAMKWLLADAERNVSKQRYKGLGEMNPGQLWETTMDPAVR
HCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
RLLRVQIEDAIAADGIFTTLMGDDVEPRRAFIESNALRAGNIDV
HHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1906260 [H]