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The map label for this gene is qor [C]

Identifier: 78050016

GI number: 78050016

Start: 5142363

End: 5143409

Strand: Reverse

Name: qor [C]

Synonym: XCV4460

Alternate gene names: 78050016

Gene position: 5143409-5142363 (Counterclockwise)

Preceding gene: 78050023

Following gene: 78050015

Centisome position: 99.32

GC content: 70.58

Gene sequence:

>1047_bases
GTGGTTGACGATGCAACTCCCTCCCGCACGACGCCTGCCATGAAAGCCATCGCCTACCCGCAACACGGCCTGCCCATCGA
CGATGCGCGCGTGCTGATCGAACTCGAGCTGCCGCTGCCCACCCCCGGCCCGCGCGACCTGCGCGTGCGCATCCACGCCG
TGTCGGTCAACCCGGTCGACACCAAGGTGCGCAGCAACGCGGCGGTGGATGCCCCGCGCGTGCTGGGCTGGGACGCCAGC
GGCGTGGTCGATGCGGTCGGCGAGGCGGTCAGCCTGTTCCGCCCCGGCGATGCGGTGTACTACGCCGGCGCGCTGACCCG
CCCGGGCACCAATGCCGAGTTCCACCTGGTCGACGAGCGCCTGGTCGGGCGCAAGCCGGCCACGCTCGACGACGCTGCGG
CCGCCGCATTGCCGCTCACCGCCATCACCGCCTGGGAGCTGCTGTTCGACCGGCTCGGCATTGCCGAAGGCGGCGGCGAA
GGCCAGGCATTGCTGGTGGTCGGTGCGGGCGGGGGCGTGGGCTCGATCCTGGTGCAGCTGGCGCGCACGCTGACCAAGCT
GACCGTCATCGGCACCGCCTCGCGCCCGGAAACCCAGGATTGGGTGCACGCACTCGGCGCGCATCACGTGATCGACCACA
GCCAGCCGCTGGGCGAGGGCCTGCAGCGGATCGGCATCGCGCAGGTGCAGCACGTCGCCAGCCTCACCCACACCGACCAG
CACTTCGCCCAACTGGTCGAGGTGCTGGCCCCGCAAGGTCAGCTGGCGCTGATCGACGACCCGGCCACGCTGGACGCGCT
GCCGCTCAAGCGCAAGAGCGTGTCGCTGCACTGGGAGCTGATGTTCACCCGCTCGCTGTTCGAAACCCAGGACATGATCG
CCCAGCACCATCTGCTCAATCGCGTCGCCGAGCTGGTGGATACCGGCGTGCTGCGCACCACCCTGGGCGAGCACTACGGC
CGCATCACCGCCGACAACCTGCGCCGCGCCCACGCCGCGCTGGAATCGCACCGCACCCGCGGCAAGCTGGTGCTGGAAGG
CTTCTGA

Upstream 100 bases:

>100_bases
GCCGCGGTCCGCACGAACAGCGCCAGGTCGTCGAAGCGGACCATCTTCACTCCAGTGGTGAAAGTGCTTGTGCAGTTTGC
CGGTTTTTTCGTGAATCCAG

Downstream 100 bases:

>100_bases
GCGCAGAGGCCTCACGCACGACAGCGCTCTGGCATGGCCGCTGTCGTGCAGCCGCACCCTTCAGCGTTGGCACGCGATCG
CCGCTGGCCAAGATCCGCGA

Product: putative oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVDDATPSRTTPAMKAIAYPQHGLPIDDARVLIELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPRVLGWDAS
GVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAAAAALPLTAITAWELLFDRLGIAEGGGE
GQALLVVGAGGGVGSILVQLARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLGEGLQRIGIAQVQHVASLTHTDQ
HFAQLVEVLAPQGQLALIDDPATLDALPLKRKSVSLHWELMFTRSLFETQDMIAQHHLLNRVAELVDTGVLRTTLGEHYG
RITADNLRRAHAALESHRTRGKLVLEGF

Sequences:

>Translated_348_residues
MVDDATPSRTTPAMKAIAYPQHGLPIDDARVLIELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPRVLGWDAS
GVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAAAAALPLTAITAWELLFDRLGIAEGGGE
GQALLVVGAGGGVGSILVQLARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLGEGLQRIGIAQVQHVASLTHTDQ
HFAQLVEVLAPQGQLALIDDPATLDALPLKRKSVSLHWELMFTRSLFETQDMIAQHHLLNRVAELVDTGVLRTTLGEHYG
RITADNLRRAHAALESHRTRGKLVLEGF
>Mature_348_residues
MVDDATPSRTTPAMKAIAYPQHGLPIDDARVLIELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPRVLGWDAS
GVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAAAAALPLTAITAWELLFDRLGIAEGGGE
GQALLVVGAGGGVGSILVQLARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLGEGLQRIGIAQVQHVASLTHTDQ
HFAQLVEVLAPQGQLALIDDPATLDALPLKRKSVSLHWELMFTRSLFETQDMIAQHHLLNRVAELVDTGVLRTTLGEHYG
RITADNLRRAHAALESHRTRGKLVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=334, Percent_Identity=26.9461077844311, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI194239676, Length=183, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI194239674, Length=183, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI13236495, Length=183, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI24308257, Length=280, Percent_Identity=27.1428571428571, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI28557745, Length=341, Percent_Identity=28.1524926686217, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1790485, Length=336, Percent_Identity=25.8928571428571, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=274, Percent_Identity=28.8321167883212, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=182, Percent_Identity=32.4175824175824, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 37323; Mature: 37323

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDDATPSRTTPAMKAIAYPQHGLPIDDARVLIELELPLPTPGPRDLRVRIHAVSVNPVD
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECCCCC
TKVRSNAAVDAPRVLGWDASGVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDER
HHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCEEEEECEECCCCCCCEEEEECHH
LVGRKPATLDDAAAAALPLTAITAWELLFDRLGIAEGGGEGQALLVVGAGGGVGSILVQL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHH
ARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLGEGLQRIGIAQVQHVASLTHTDQ
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
HFAQLVEVLAPQGQLALIDDPATLDALPLKRKSVSLHWELMFTRSLFETQDMIAQHHLLN
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHH
RVAELVDTGVLRTTLGEHYGRITADNLRRAHAALESHRTRGKLVLEGF
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MVDDATPSRTTPAMKAIAYPQHGLPIDDARVLIELELPLPTPGPRDLRVRIHAVSVNPVD
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECCCCC
TKVRSNAAVDAPRVLGWDASGVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDER
HHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCEEEEECEECCCCCCCEEEEECHH
LVGRKPATLDDAAAAALPLTAITAWELLFDRLGIAEGGGEGQALLVVGAGGGVGSILVQL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHH
ARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLGEGLQRIGIAQVQHVASLTHTDQ
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
HFAQLVEVLAPQGQLALIDDPATLDALPLKRKSVSLHWELMFTRSLFETQDMIAQHHLLN
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHH
RVAELVDTGVLRTTLGEHYGRITADNLRRAHAALESHRTRGKLVLEGF
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA