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The map label for this gene is uxaC [H]

Identifier: 78049913

GI number: 78049913

Start: 5010970

End: 5012388

Strand: Reverse

Name: uxaC [H]

Synonym: XCV4357

Alternate gene names: 78049913

Gene position: 5012388-5010970 (Counterclockwise)

Preceding gene: 78049914

Following gene: 78049912

Centisome position: 96.79

GC content: 65.4

Gene sequence:

>1419_bases
ATGCGTTCTTCCGTGTTGTCCTTGCATCCCGATCGTTTGCTGCCGGCCGATCCCGGCACGCGCGCGATCGCCCGCCGCCT
GTACGCACAGGTTGCAACGCTGCCGATCATCAGCCCGCATGGCCACACCGACCCGGCCTGGTTCGCCACCAATGCACCGT
TTGCCAACGCCACCGAACTGTTGTTGGTGCCGGACCATTATGTATTCCGCATGTTGTACAGCCAGGGCATCGACCTCGAT
GCCCTGGGCATCCCGCGCGCAGATGGAACCCGCGCAGCAGTCGACCCGCGTGCGGCATGGCGCGTGTTTGCCGAGCACTA
CACGTTGTTGCGCGGCACGCCGTCGGCGCTATGGCTCAATCATGTGTTCCATGATGTCTTCGATTTGCGTATCCGTCTCG
ATGCCGGCACCGCCGATCACTATTACGACCACATCACCGCCGCGCTGCAAACGCCAGCATTCCTGCCGCGTGCGCTGTTC
GAGCGCTTCAATATCGAGGTGATCGCCACCACCGAATCGCCGCTGGATCGGCTGCAGCACCATGCGGCCATTGCCGCCAG
CGGTTGGCAGGGACGGGTGGTGACGGCGTATCGCCCTGACCCGGTCGTGGACCCGGAGCACGAGCAGTTCGCCGGCGCGC
TGCAGCAGTTCGGCGCGCTCACCGGTGAGGACGTGCTCAGCTGGGATGGCTACTTGCGCGCGCATCGGCAACGGCGTGCG
TTCTTTGCCGCGCACGGCGCCACCTCGACCGATCACGGGCACCCCAGCGCCGCGACCGCCGATCTGTCGCCGGTCCAAGC
GCAGCGCCTGTTCGATACGGTGGTGCGCGGTGAGGCCACGCCGGAGCAGGCCGAACTGTTTCGTGCGCAGGTGCTGACCG
AAATGGCGGCGATGAGCCTTGACGACGGCCTGGTGATGCAGCTGCATCCGGGCTGCTTCCGCAATCACAATCGGCAGCTG
TTCGAGCAGTACGGACGCGACAAGGGCGCCGACATTCCGATGCGCACCGACTACGTGCATGCGTTGAAGCCCTTGCTGGA
TCGGCATGGCAACGACCCGCGCCTGCGCCTGATCGTGTTCACCCTGGACGAAACCAGCTACAGCCGCGAGCTGGCGCCAT
TGGCCGGGCATTACCCCTCCCTGCTGCTCGGCCCGGCGTGGTGGTTCCATGATGCGCCGGAGGGCATGTGGCGCTTTCGC
GAGCAGACCCTGGCCAGCGCCGGCTTCTACAACACCGTGGGCTTCAACGACGATACCCGCGCATTCCTGTCCATTCCCGC
GCGGCACGATGTGGCGCGGCGCGTGGACAGCGCCTTCCTGGCCAAACTCGTTGCCGAGCACCGGCTGGAAGAGGACGAGG
CAACCGAGGTGGCAATCGACCTGGCCTACCGCCTACCCAAGCAAGCGTACAACTTGTGA

Upstream 100 bases:

>100_bases
GACGGCAGCGAACGCCCGGCCTTGACCTGGCTACGCAGCTACGTTGCCAGCAGGCCCTGACCGGGCTTCCTTCTCATTGT
CCATAGGGCTGATATCGATC

Downstream 100 bases:

>100_bases
GGTGGCGTAAACGGAGGGCGGCAGTGCCGAGGCGTGCGCACGCGGCGCCACTGCATCCTGCGCAGCGGCAGGATCGGTGA
ACTGATGCGTGCACACGCCA

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATELLLVPDHYVFRMLYSQGIDLD
ALGIPRADGTRAAVDPRAAWRVFAEHYTLLRGTPSALWLNHVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALF
ERFNIEVIATTESPLDRLQHHAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLSWDGYLRAHRQRRA
FFAAHGATSTDHGHPSAATADLSPVQAQRLFDTVVRGEATPEQAELFRAQVLTEMAAMSLDDGLVMQLHPGCFRNHNRQL
FEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVFTLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFR
EQTLASAGFYNTVGFNDDTRAFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYNL

Sequences:

>Translated_472_residues
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATELLLVPDHYVFRMLYSQGIDLD
ALGIPRADGTRAAVDPRAAWRVFAEHYTLLRGTPSALWLNHVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALF
ERFNIEVIATTESPLDRLQHHAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLSWDGYLRAHRQRRA
FFAAHGATSTDHGHPSAATADLSPVQAQRLFDTVVRGEATPEQAELFRAQVLTEMAAMSLDDGLVMQLHPGCFRNHNRQL
FEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVFTLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFR
EQTLASAGFYNTVGFNDDTRAFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYNL
>Mature_472_residues
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATELLLVPDHYVFRMLYSQGIDLD
ALGIPRADGTRAAVDPRAAWRVFAEHYTLLRGTPSALWLNHVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALF
ERFNIEVIATTESPLDRLQHHAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLSWDGYLRAHRQRRA
FFAAHGATSTDHGHPSAATADLSPVQAQRLFDTVVRGEATPEQAELFRAQVLTEMAAMSLDDGLVMQLHPGCFRNHNRQL
FEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVFTLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFR
EQTLASAGFYNTVGFNDDTRAFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYNL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family [H]

Homologues:

Organism=Escherichia coli, GI2367192, Length=440, Percent_Identity=28.4090909090909, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003766
- InterPro:   IPR023177 [H]

Pfam domain/function: PF02614 UxaC [H]

EC number: =5.3.1.12 [H]

Molecular weight: Translated: 52923; Mature: 52923

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATEL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCCCCCEE
LLVPDHYVFRMLYSQGIDLDALGIPRADGTRAAVDPRAAWRVFAEHYTLLRGTPSALWLN
EECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
HVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALFERFNIEVIATTESPLDRLQH
HHHHHHHEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEEECCHHHHHHHH
HAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLSWDGYLRAHRQRRA
HHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FFAAHGATSTDHGHPSAATADLSPVQAQRLFDTVVRGEATPEQAELFRAQVLTEMAAMSL
HEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
DDGLVMQLHPGCFRNHNRQLFEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVF
CCCEEEEECCCHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
TLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFREQTLASAGFYNTVGFNDDTR
EECCCCCHHHHHHHHCCCCHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
AFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYNL
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATEL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCCCCCEE
LLVPDHYVFRMLYSQGIDLDALGIPRADGTRAAVDPRAAWRVFAEHYTLLRGTPSALWLN
EECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
HVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALFERFNIEVIATTESPLDRLQH
HHHHHHHEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEEECCHHHHHHHH
HAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLSWDGYLRAHRQRRA
HHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FFAAHGATSTDHGHPSAATADLSPVQAQRLFDTVVRGEATPEQAELFRAQVLTEMAAMSL
HEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
DDGLVMQLHPGCFRNHNRQLFEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVF
CCCEEEEECCCHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
TLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFREQTLASAGFYNTVGFNDDTR
EECCCCCHHHHHHHHCCCCHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
AFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYNL
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]