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The map label for this gene is uvrD [H]

Identifier: 78049804

GI number: 78049804

Start: 4876347

End: 4878518

Strand: Reverse

Name: uvrD [H]

Synonym: XCV4248

Alternate gene names: 78049804

Gene position: 4878518-4876347 (Counterclockwise)

Preceding gene: 78049805

Following gene: 78049802

Centisome position: 94.21

GC content: 65.29

Gene sequence:

>2172_bases
TTGCTCGATCATTTAAACCCCGCCCAGCGTGAGGCCGTTTCTGCGCCGCCGGGGCATTACCTCGTGCTGGCCGGCGCCGG
CTCCGGCAAGACGCGCGTGCTGATCCATCGCATCGCCTGGCTCAACGAAGTCCAGGGCGTGCCCAACCACGGCATCTTCG
CGGTGACCTTCACCAACAAGGCGGCCGGCGAAATGCGTCACCGCACCGACCTGCAGCTGCGCAATGGCAGCCGCGGGATG
TGGATCGGTACATTTCACGGGCTGGCCCATCGCCTGTTGCGTCTGCATTGGCAGGACGCGCGGTTGCCGGAAGGCTTCCA
GGTCATGGACAGCGACGACCAGTTGCGGTTGGTCAAGCGCGTGGTGCAGGCGCTGGAGCTGGACGAGAGCAAGTATCCGC
CCAAGCAGATGAGCTGGTGGATCAACGAGCAGAAGGATGAGGGCCGCCGTCCGCAGCATATCCAGCCCGAGCCCAACGAC
GATTGGACCGAGGTGCGCCGGCAGGTGTATGCGGCTTATCAGGAACGCTGCGACCGCTCCGGGCTGCTGGATTTCGCCGA
GTTGCTGCTGCGCGCGCACGAGTTGCTGCGCGACACCCCGGCCTTGCTGGCGCATTACCGTGCGCGCTTCCGCGAGATTC
TGGTCGACGAGTTCCAGGACACCAACGCCATCCAGTACGCCTTCGTGCGCGTGCTGGCCGGCGAATCGGGCAATGTATTC
GTGGTGGGTGACGACGACCAGGCCATCTACGGCTGGCGCGGCGCCAAGGTCGAGAACGTCCAGCGTTTTCTCAAAGATTT
CCCCGGCGCGCAGACCGTGCGGCTGGAGCAGAACTACCGCTCCAGCGCCAATATCCTGGGCGCGGCCAATGCGGTGATCG
CGCACAATCCGGACCGCATCGGCAAGCAGCTGTGGACCGATTCCGGCGATGGCGATCCGATCGATCTGTATGCGGCCTAC
AACGAAGTGGACGAGGCGCGTTATGTGGTCGAGCGTGCACGGCAGTGGGTGCGCGACGGCGGTAGTTATGGCGAAGTAGC
GGTGCTCTACCGCAGCAATGCGCAATCGCGCGCGCTGGAAGAAGCGCTGATTTCCGAGCAGTTGCCGTACCGCGTGTATG
GCGGTATGCGCTTCTTCGAACGTGCCGAAATCAAGGACGCGTTGGCTTATTTGCGCCTGCTCACCAACCGCAGCGACGAC
GCGGCCTTCGAACGCGCGGTCAACACGCCCACGCGTGGCATTGGCGACCGGACGCTGGATGAGGTGCGCCGGCTGGCGCG
TGCCAGTGCGCTGTCGTTGTGGGAAGCGGCCATGTTGTGCACGCAGCAGAACACGCTGGCCGCACGCGCACGCAATGCCC
TGGCCAGCTTCCTCAGCCTGATCGGCCAGCTGCATGCCGAAACCGGACAGATGGAACTGGCCGAACGCATCGACCATGTG
CTGATGCGCTCGGGTCTGCGCGAGCATTGGGCCAAGGAAAGCCGTGGCGGGCTGGATTCGGAATCGCGTACCGAGAACCT
GGACGAACTGGTGTCGGTCGCCTCGCGCTTCACCCGCCCCGACGACGAAGACAGCCAGGGCATGACCGAGCTGGTCGCCT
TCCTGGCCTATGCCTCGCTGGAGGCCGGCGAAGGCCAGGCCCAGGCTGGCGAGGAAGGCGTGCAGCTGATGACATTGCAT
TCGGCCAAGGGCCTGGAATTCCCCATCGTGTTCCTGGTCGGTCTGGAAGACGGCCTGTTCCCCAGCGCACGCTCGTTGGA
AGAGAGCGGCCGGCTGGAAGAGGAGCGTCGCCTGGCGTACGTGGGCATCACCCGCGCGCGGCAGAAGCTGGTGCTGTGCT
ACGCCGAATCGCGCCGCATCCACGGCCAGGACAACTACAACGTGCCCTCGCGCTTCCTGCGCGAGATTCCGCGCGACCTG
CTCAACGAAGTACGCCCCAAGGTGCAGGTTTCGCGCACCGCATCGCTGGGCGCGGCCCGCGGCGGCCCGGTACATGGCAT
CGTGGAGACCGCGCCGATCAAGCTCGGCGCCAACGTCGAACACCCCAAGTTCGGCGGCGGCGTGGTGGTCGATTACGAAG
GCGCTGGCGCGCATGCGCGCGTGCAGGTGCAGTTCGACGAGGTCGGCGCCAAGTGGCTGGTGATGGCCTACGCCAATCTG
ACTGTGGTGTAG

Upstream 100 bases:

>100_bases
GCTGACATGTCCAGGAAGGCCCTCTTCCCAAACCGCTTCATCGCAATCTCAGCCGCAGCGACGCCACAACCGGTAAAATG
CGCCGGTGGATGTCTCTCAT

Downstream 100 bases:

>100_bases
GCGGCTCGGCACTCGTCAGCGATTGCGCGTTGTTCAGCAGGCGAGGGCGTCGTGCCGTTGCATTGTGCGTGCAGCAAGCA
GAGCCGACCGCTGCTGCACT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 723

Protein sequence:

>723_residues
MLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNKAAGEMRHRTDLQLRNGSRGM
WIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPND
DWTEVRRQVYAAYQERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGESGNVF
VVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRIGKQLWTDSGDGDPIDLYAAY
NEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDD
AAFERAVNTPTRGIGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALASFLSLIGQLHAETGQMELAERIDHV
LMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASLEAGEGQAQAGEEGVQLMTLH
SAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDL
LNEVRPKVQVSRTASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWLVMAYANL
TVV

Sequences:

>Translated_723_residues
MLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNKAAGEMRHRTDLQLRNGSRGM
WIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPND
DWTEVRRQVYAAYQERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGESGNVF
VVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRIGKQLWTDSGDGDPIDLYAAY
NEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDD
AAFERAVNTPTRGIGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALASFLSLIGQLHAETGQMELAERIDHV
LMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASLEAGEGQAQAGEEGVQLMTLH
SAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDL
LNEVRPKVQVSRTASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWLVMAYANL
TVV
>Mature_723_residues
MLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNKAAGEMRHRTDLQLRNGSRGM
WIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPND
DWTEVRRQVYAAYQERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGESGNVF
VVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRIGKQLWTDSGDGDPIDLYAAY
NEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDD
AAFERAVNTPTRGIGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALASFLSLIGQLHAETGQMELAERIDHV
LMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASLEAGEGQAQAGEEGVQLMTLH
SAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDL
LNEVRPKVQVSRTASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWLVMAYANL
TVV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=723, Percent_Identity=59.1977869986169, Blast_Score=863, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=644, Percent_Identity=38.3540372670807, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322369, Length=757, Percent_Identity=25.2311756935271, Blast_Score=170, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6324477, Length=678, Percent_Identity=21.0914454277286, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81048; Mature: 81048

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNK
CCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
AAGEMRHRTDLQLRNGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKR
HHHHHHHHCCCEEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHH
VVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPNDDWTEVRRQVYAAYQERCDRS
HHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGESGNVF
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEE
VVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRI
EEECCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHCCCCEEEECCHHHH
GKQLWTDSGDGDPIDLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALE
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
EALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDDAAFERAVNTPTRGIGDRTLD
HHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHH
EVRRLARASALSLWEAAMLCTQQNTLAARARNALASFLSLIGQLHAETGQMELAERIDHV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASL
HHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
EAGEGQAQAGEEGVQLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAY
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCHHHHEEH
VGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDLLNEVRPKVQVSRTASLGAAR
EEHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCC
GGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWLVMAYANL
CCCCCCEEECCCEEECCCCCCCCCCCCEEEEECCCCCEEEEEEEEHHCCCCEEEEEEECE
TVV
EEC
>Mature Secondary Structure
MLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNK
CCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
AAGEMRHRTDLQLRNGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKR
HHHHHHHHCCCEEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHH
VVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPNDDWTEVRRQVYAAYQERCDRS
HHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGESGNVF
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEE
VVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRI
EEECCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHCCCCEEEECCHHHH
GKQLWTDSGDGDPIDLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALE
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
EALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDDAAFERAVNTPTRGIGDRTLD
HHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHH
EVRRLARASALSLWEAAMLCTQQNTLAARARNALASFLSLIGQLHAETGQMELAERIDHV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASL
HHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
EAGEGQAQAGEEGVQLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAY
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCHHHHEEH
VGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDLLNEVRPKVQVSRTASLGAAR
EEHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCC
GGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWLVMAYANL
CCCCCCEEECCCEEECCCCCCCCCCCCEEEEECCCCCEEEEEEEEHHCCCCEEEEEEECE
TVV
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]