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The map label for this gene is zwf2 [H]

Identifier: 78049724

GI number: 78049724

Start: 4776771

End: 4778600

Strand: Reverse

Name: zwf2 [H]

Synonym: XCV4168

Alternate gene names: 78049724

Gene position: 4778600-4776771 (Counterclockwise)

Preceding gene: 78049725

Following gene: 78049723

Centisome position: 92.28

GC content: 63.66

Gene sequence:

>1830_bases
ATGAGTGAGCAAGCAACCACACCGCCGTGCATCATCGTGGTGTTCGGCGCACGCGGCGATCTGACCAAGCGCCTGGTCAT
GCCGGCGCTGTACAACCTGCGCCGTTCCGGTGCGCTGGGCGATGAGTTCGCCATTGTCGGCATGGACCATGGCGACATCA
GCGAACGCGCGTGGCGGACCAACATGGGGCAGTCGATGACGCAGCTGCTCAGCAGTCGCGATGCCGAATTCCAGACCGAC
GAATTCGACACCGCCACCTGGGACTGGTTGCGCGAGCGCATGCATTACCTGCGCGGCGACTTCACCGATCAGGGAGCCTA
CCGATCGCTGGGCGGCGTGCTGGACAAGCTGCACAAGCGCTATGGCACGCAGGGCAACGTGCTGTTCTATCTGGCCACCG
CCGCGCGCTTCTTCGAGCCGGTATTGCTTAACCTGGGCGAGGCTGGCCTGGTCAGGCAACGCGAAGGCGAAGGCTGGCGC
CGGGTAATCGTGGAAAAACCCTTCGGCCACGATCTGCCCAGCGCCCAGCATCTCAATGCCACGGTCGCCAAGGTGCTGCA
CGAAGATCAGGTGTTCCGCATCGATCATTTCCTGGGCAAGGAAACCGTGCAGAACATTCTCGCGTTCCGCTTCGCCAATG
GCTTGTTCGAGCCGGTGTGGAATCGCGATCGCATCGACCATGTGCAGATCACCGCGGCCGAAACCATCGGCGTGGAAGGG
CGCGGGCGGTTCTACGACCCTACCGGCTGCCTGCGCGACATGGTGCCGAACCATCTGTTCCAGTTGCTGGCGATGATTGC
GATGGAACCGCCGGCGGCGTTCACTACCGAGGCGATGCATCGCCGTCGCGCCGAAGTGATCGAGGCGGTGCGCCCGATCA
GGCCCGAAGATGTGGTGCGCGGGCAATATGCCTCCGGCGCGGTCAATCGCAATGCGGTGCCGGGCTATCGCGAAGAAGAC
ACCGTGCCCGAGGATTCGGACACCGAAACCTATGTGGCGATGAAGCTGCAGGTCGACACCTGGCGCTGGGCCGGCGTGCC
GTTCTACCTGCGCACCGGCAAGCGCCTGCGCGAACGCACCACCGAGATCGCGATCCGTTTCAAGCCCGCACCGCTGGCCC
CGTTCCGCAGCACCGAAGTGGGCGGCTATGGCCCCGACTGGCTGGTGCTGCATATCCAGCCCGACGAGGGCATCTCGCTG
CAGTTCGACGTCAAGCGCCCCGGCGCGCAGGTCGCACTGGCGCCGGTACGCATGGATTTCCGCTATCGCGACTGGTTTCC
CAAGGAATACACCGTGGGCTACGAACGCCTGCTGCAGGACTGCATGAACGGCGAAGCCGGCCTGTTCCAGGACGCGGCCA
TGGTGGAAGGCGCATGGCGCATCGTGCAACCGATCCTGGATGCATGGAAACAACCGCCCAGCGACTTCCCTAACTACGCC
GCAGGCAGCGCCGGCCCCTCGGCCGCCGACGCCTTGCTGGCCATGAACGGCGGACACGCCTGGCGCGCCCTCACTCCCGG
CCGCAAACCCCCACCACGCCGTCCCCCAGAAGCGCGTGCTGGTGCTGCGACGCCGGTGAAGAAAGCCACCAAGAAGATCG
CGAAGAAAGCGAGCAAGGCGACATCCAAGCGTGCCGGTAAACCTGCTGCAAAATCCGCTGAAACCGGAGCCGATTCATCT
AGCAAGCCTACGAAAAAATCGGGCGTCAAACGTGCAACGAAGGAGGTCGCAAAAAAGACTGCGAAGACCGTAAGGAAAAC
CGCGGCCGGCAAAGTTGTCGCGACGAAGTTGGTTAGCAAGAGTGTAGCTGCGCGTAAAGCGCGCCGCTGA

Upstream 100 bases:

>100_bases
AACGCATGCTCGGCAACTTCCCGCAAGGGTATTCCCACGTGGCCCTGGTCAATGCGGCATTGCGCCTGCATGGACGCATG
GGCGAAAAGGAAACGCATCC

Downstream 100 bases:

>100_bases
TTTTGCAAGCGCCGACCATAGCGTGGCGACTGGCGCTTGATTGGAGCAAGCGATGCAGCTTTTGACTTGCGTCATGATGC
TCGTTACTCAGCTACAGGCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRSGALGDEFAIVGMDHGDISERAWRTNMGQSMTQLLSSRDAEFQTD
EFDTATWDWLRERMHYLRGDFTDQGAYRSLGGVLDKLHKRYGTQGNVLFYLATAARFFEPVLLNLGEAGLVRQREGEGWR
RVIVEKPFGHDLPSAQHLNATVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIRPEDVVRGQYASGAVNRNAVPGYREED
TVPEDSDTETYVAMKLQVDTWRWAGVPFYLRTGKRLRERTTEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISL
QFDVKRPGAQVALAPVRMDFRYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPEARAGAATPVKKATKKIAKKASKATSKRAGKPAAKSAETGADSS
SKPTKKSGVKRATKEVAKKTAKTVRKTAAGKVVATKLVSKSVAARKARR

Sequences:

>Translated_609_residues
MSEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRSGALGDEFAIVGMDHGDISERAWRTNMGQSMTQLLSSRDAEFQTD
EFDTATWDWLRERMHYLRGDFTDQGAYRSLGGVLDKLHKRYGTQGNVLFYLATAARFFEPVLLNLGEAGLVRQREGEGWR
RVIVEKPFGHDLPSAQHLNATVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIRPEDVVRGQYASGAVNRNAVPGYREED
TVPEDSDTETYVAMKLQVDTWRWAGVPFYLRTGKRLRERTTEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISL
QFDVKRPGAQVALAPVRMDFRYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPEARAGAATPVKKATKKIAKKASKATSKRAGKPAAKSAETGADSS
SKPTKKSGVKRATKEVAKKTAKTVRKTAAGKVVATKLVSKSVAARKARR
>Mature_608_residues
SEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRSGALGDEFAIVGMDHGDISERAWRTNMGQSMTQLLSSRDAEFQTDE
FDTATWDWLRERMHYLRGDFTDQGAYRSLGGVLDKLHKRYGTQGNVLFYLATAARFFEPVLLNLGEAGLVRQREGEGWRR
VIVEKPFGHDLPSAQHLNATVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEGR
GRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIRPEDVVRGQYASGAVNRNAVPGYREEDT
VPEDSDTETYVAMKLQVDTWRWAGVPFYLRTGKRLRERTTEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISLQ
FDVKRPGAQVALAPVRMDFRYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYAA
GSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPEARAGAATPVKKATKKIAKKASKATSKRAGKPAAKSAETGADSSS
KPTKKSGVKRATKEVAKKTAKTVRKTAAGKVVATKLVSKSVAARKARR

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=490, Percent_Identity=34.2857142857143, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI108773793, Length=490, Percent_Identity=34.2857142857143, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI52145310, Length=371, Percent_Identity=30.9973045822102, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1788158, Length=504, Percent_Identity=37.1031746031746, Blast_Score=337, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17538218, Length=505, Percent_Identity=33.6633663366337, Blast_Score=297, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=487, Percent_Identity=33.6755646817248, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24643350, Length=504, Percent_Identity=32.3412698412698, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24643352, Length=504, Percent_Identity=32.3412698412698, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=29.7520661157025, Blast_Score=204, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 67738; Mature: 67607

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRSGALGDEFAIVGMDHGDISERAWRT
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHH
NMGQSMTQLLSSRDAEFQTDEFDTATWDWLRERMHYLRGDFTDQGAYRSLGGVLDKLHKR
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YGTQGNVLFYLATAARFFEPVLLNLGEAGLVRQREGEGWRRVIVEKPFGHDLPSAQHLNA
HCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHH
TVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCC
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIRPEDVVR
CCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GQYASGAVNRNAVPGYREEDTVPEDSDTETYVAMKLQVDTWRWAGVPFYLRTGKRLRERT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCCEECCCHHHHHHH
TEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISLQFDVKRPGAQVALAPVRMDF
HEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEEECC
RYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPEARAGAATPVKKATKKIAKKASKA
CCCCCCHHHHHHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TSKRAGKPAAKSAETGADSSSKPTKKSGVKRATKEVAKKTAKTVRKTAAGKVVATKLVSK
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SVAARKARR
HHHHHHCCC
>Mature Secondary Structure 
SEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRSGALGDEFAIVGMDHGDISERAWRT
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHH
NMGQSMTQLLSSRDAEFQTDEFDTATWDWLRERMHYLRGDFTDQGAYRSLGGVLDKLHKR
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YGTQGNVLFYLATAARFFEPVLLNLGEAGLVRQREGEGWRRVIVEKPFGHDLPSAQHLNA
HCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHH
TVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCC
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIRPEDVVR
CCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GQYASGAVNRNAVPGYREEDTVPEDSDTETYVAMKLQVDTWRWAGVPFYLRTGKRLRERT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCCEECCCHHHHHHH
TEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISLQFDVKRPGAQVALAPVRMDF
HEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEEECC
RYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPEARAGAATPVKKATKKIAKKASKA
CCCCCCHHHHHHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TSKRAGKPAAKSAETGADSSSKPTKKSGVKRATKEVAKKTAKTVRKTAAGKVVATKLVSK
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SVAARKARR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]