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The map label for this gene is aroE [H]

Identifier: 78049682

GI number: 78049682

Start: 4721378

End: 4722229

Strand: Reverse

Name: aroE [H]

Synonym: XCV4126

Alternate gene names: 78049682

Gene position: 4722229-4721378 (Counterclockwise)

Preceding gene: 78049684

Following gene: 78049681

Centisome position: 91.19

GC content: 68.9

Gene sequence:

>852_bases
ATGCCCGTATCCCGTTATGCCGTGTTCGGTCACCCTGTCGCCCATTCGCTGTCGCCGGCCATCCACACCGAGTTCGGGAA
GCAGACCGGCATTGCGCTGGACTACACCGCCATCGACGCGCCGCTGGAGGATTTCAGCGCCGCGTTGCAACGCTTCGCCG
ATGAGGGCGGCAAGGGCGCCAACGTCACCCTGCCGTTGAAGGAAGCCGCCTATGCGCTGGCCAGCAGTCTGAGCGATCGC
GCGCGGTTGGCCGGGGCGGTGAACACGTTGGTGCGCAATGACGGCCAGTGGCAGGGCGACAACACCGACGGCGCCGGCCT
GGTGCGCGATCTCACCGAACGCCAGGGCCTGGATCTGCGTGGCCGCCGCGTGCTGCTGCTGGGCGCCGGTGGTGCTGCAC
GCGGTGTGGCGCCGGCGCTGCTGGAGGCGGGCATCACCGCAATGGTGGTGGTGAACCGCTCGCCCGAGCGCGCCGATGCC
TTGTGCGATGCGCTGGGCGAGCCGGCGCGGGTGACGTCGCGTTACATCGAAGACCTGCGCGAGCTGGGCGACTTCGAACT
GATCGTCAATGCCACTGCCGCCGGTCGCGACCGCGATGCCGGTGCGTTCGCATTGCCACTGGGTCTGGTCAACAGCCTGA
CGGCCGCGGTCGATCTGAATTACGGCGACACCGCCATTGCGTTTCTGGCCTGGGCGCGCGCGGCGCAATGCCGGTACGCC
ATCGATGGACTGGGCATGCTGGTGGAACAGGCTGCCGAGAGCTTCGCGCTGTGGCATGGCGTGCGCCCGGACACCGACCC
GGTCTATGCCGCGCTGCGCGCGCGCGAGGCCGTGCTGGTCAGTGCCGACTGA

Upstream 100 bases:

>100_bases
TGCCGCCAGCGTAAGCAGCGTCCATCGATAGTGCATGCGGTGTTCCTGCCTCAAGAGCGGCTCCAAGTCGCGCACAGTCT
AGTCAACCAGAGAGTGTTTC

Downstream 100 bases:

>100_bases
CGTGGGCAGCGCCGATGCCACCGCGATCCTGCTAACCCTGGTCACCAGCCTGCTGTCGCGCGTGCCGATGCTGATTGCGG
TGCTGCTCGGGCTGGCTCTG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPVSRYAVFGHPVAHSLSPAIHTEFGKQTGIALDYTAIDAPLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDR
ARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADA
LCDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD

Sequences:

>Translated_283_residues
MPVSRYAVFGHPVAHSLSPAIHTEFGKQTGIALDYTAIDAPLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDR
ARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADA
LCDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
>Mature_282_residues
PVSRYAVFGHPVAHSLSPAIHTEFGKQTGIALDYTAIDAPLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDRA
RLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADAL
CDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYAI
DGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=45.2205882352941, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1787983, Length=274, Percent_Identity=29.1970802919708, Blast_Score=114, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320332, Length=280, Percent_Identity=25, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29783; Mature: 29652

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSRYAVFGHPVAHSLSPAIHTEFGKQTGIALDYTAIDAPLEDFSAALQRFADEGGKGA
CCCCCEEEECCCHHHHCCHHHHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHHHHCCCCCC
NVTLPLKEAAYALASSLSDRARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCC
GRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADALCDALGEPARVTSRYIEDLR
CCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHH
ELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
HCCCEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECC
>Mature Secondary Structure 
PVSRYAVFGHPVAHSLSPAIHTEFGKQTGIALDYTAIDAPLEDFSAALQRFADEGGKGA
CCCCEEEECCCHHHHCCHHHHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHHHHCCCCCC
NVTLPLKEAAYALASSLSDRARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCC
GRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADALCDALGEPARVTSRYIEDLR
CCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHH
ELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
HCCCEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]