Click here to switch to the map view.

The map label for this gene is phoQ [H]

Identifier: 78049671

GI number: 78049671

Start: 4710572

End: 4711987

Strand: Reverse

Name: phoQ [H]

Synonym: XCV4115

Alternate gene names: 78049671

Gene position: 4711987-4710572 (Counterclockwise)

Preceding gene: 78049672

Following gene: 78049670

Centisome position: 90.99

GC content: 63.56

Gene sequence:

>1416_bases
GTGCCGGGCCGCTCCAAGTGGTATAGACGCTGGCGGCCGCGCTCATTGCAGGCCCGCCAGCTGCTGGCCGCCAGCCTCAG
CCTGGTGGCCTTCCTGGCGCTGGCGGGTTACGCGCTGGACGTGGCATTTGCCGACACCGCCGAGAAGAACCTGCGTGAGC
GGCTGAAGAACTACGCCTCCGCGTATGCGGCCAATATCGATTTCGTACGCGACGGGTCGCTGTACATCGGCGGGCAACCG
CCCGGTCCGCGCTTCGATGTGCCTGGCGGCGGGCTCTACGTTGAAGTTGTACGCCCGGACGAAAGCTGGACCTCGATGTC
GGCCGAAGGCCCGAACATTCCGCATGGCCGCATGCTGGAGCCGCGCCAGGAAGAATTCATCGGCCCGCTGGAAATGACCC
AGATCGACGGCAGCCTGGGCCAGCTGTATCGCTACGGGCTGGGCGTGAGCTATGTCGAACGCGAGCACGGCGGCGAGATT
CCGTACACCATCTACGTGATGGAGGACGCGCGCTCGATGGGTGCGCAGCTGCGCGTGTTCCGTGGTGCAGTGTGGTTCTA
CCTTGGCAGCGCCGGTGTGGTGTTGCTGGTATTGCAAGCCTCCATTCTGCAATGGAGCCTGCGTCCGCTGCGGCGGGTCA
TCAACGAGTTGACCAAGGTGCAGCGCGGCGAGATCCAGCGCATGAGCGAGCAGCATCCACGCGAACTGGAGCCGCTGACC
GACAGCATCAATGCCTTCATCGAAAGCGAACGCGACAACCTGGAGCGTCAGCGCAACACGCTGGCCGATCTTGCGCATAG
CCTCAAGACGCCCATTGCCGTCTTGCGCACACAACTCGATAGCGGTGCGTCCGAGCGCGATCTGCACGAAGAGATGGATG
TGCAGCTGCGCCGCATGAACGACCTGGTGTCGTACCAGCTGGCGCGCGCGGCGTCCAGCGGGCACAAATTGTTCGCGGCA
CCATTGCCCATCGAACCGACCGCCGAAGAAATCGTGCGTGGCCTTGAGAAGGTGTATTCGGTTAAAGGCGTGTTGTGCGA
ATTCGATATTTCGCCCGAAGCACGCTTTCACGGCGAGCCGGGCGATTTGCAGGAACTGCTTGGAAATTTGCTGGAAAACG
GCTTCAAGTGGGCGCGCAGCCGGGTGCTGCTGACCGCAAAACCGGGACCCACTACCGGTAGCCGTCGTGCCGGCCTGATT
CTGTCGGTGGAAGACGACGGCCCCGGCATCGCGCCGGAAGACGTGGCCAAGATTCTGCAGCGCGGTGTGCGTGGTGACGA
GCGTGTGCAAGGGCATGGCATCGGCATGTCGATCGTGCAGGACCTGATCAAGGGCTATCGCGGCGAGCTGCAGGTGGTGC
GCTCGCAGGAACTGGGCGGTGCCCGCTTCGATGTGACCCTGCCGCCGGGATTGTGA

Upstream 100 bases:

>100_bases
GCGAACTCAAGCCGATCGAAACCGTGCGTGGCCGTGGTTACCGCTTCGCCATTCCGCGTACCGAAGGCTGAGTCAGCGCG
TCAGCGAGCAGGAAGACCAA

Downstream 100 bases:

>100_bases
CCGCCGCAGGGCCGATGAACCCGTGGCCAATGTGCGCTGGCCTTCCGACAACCGTTTAACGCCTCACGCGTTGGCTTACC
CATACTGGGCGGGCAAGCCG

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQP
PGPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEI
PYTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQASILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAA
PLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLI
LSVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL

Sequences:

>Translated_471_residues
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQP
PGPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEI
PYTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQASILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAA
PLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLI
LSVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL
>Mature_470_residues
PGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQPP
GPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIP
YTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQASILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLTD
SINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAAP
LPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLIL
SVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=290, Percent_Identity=35.1724137931034, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=27.355623100304, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=23.5507246376812, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=23.6363636363636, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=27.7310924369748, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=29.2181069958848, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=27.0386266094421, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=29.6296296296296, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52320; Mature: 52189

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYAS
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAANIDFVRDGSLYIGGQPPGPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLE
HHHCCCEEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
PRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIPYTIYVMEDARSMGAQLRVF
CHHHHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
RGAVWFYLGSAGVVLLVLQASILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DLVSYQLARAASSGHKLFAAPLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEP
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
GDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLILSVEDDGPGIAPEDVAKILQ
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCEEEEECCCCC
>Mature Secondary Structure 
PGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYAS
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAANIDFVRDGSLYIGGQPPGPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLE
HHHCCCEEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
PRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIPYTIYVMEDARSMGAQLRVF
CHHHHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
RGAVWFYLGSAGVVLLVLQASILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DLVSYQLARAASSGHKLFAAPLPIEPTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEP
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
GDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLILSVEDDGPGIAPEDVAKILQ
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]