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The map label for this gene is trpS [H]

Identifier: 78049654

GI number: 78049654

Start: 4695782

End: 4697071

Strand: Reverse

Name: trpS [H]

Synonym: XCV4098

Alternate gene names: 78049654

Gene position: 4697071-4695782 (Counterclockwise)

Preceding gene: 78049655

Following gene: 78049653

Centisome position: 90.7

GC content: 62.95

Gene sequence:

>1290_bases
ATGACCACCCGTGTCCTTACCGGCATCACCACCTCCGGCACCCCGCACCTGGGCAATTATGTCGGTGCAATCCGCCCGGC
CATCCAGGCCAGTGCAGGTGCCGATACGGAGAGCTTCTATTTCCTGGCCGATCTGCACAGCCTGATCAAGGCGCAGGACC
CGGCGCGCACGCAGCGTTCGACACTGGAAATCGCCGCCACCTGGCTGGCCTGCGGCCTGGACCCGGACAAGGTGTGGTTC
TACCGGCAGTCCGATGTGCCCGAGACCACCGAGTTGATGTGGTTGCTGACCTGCGTGGCCGGCAAGGGCATCCTCAATCG
CGCGCATGCCTACAAGGCGGCGGTGGACAAGAACCGCGCCGATGGCGAGGACGAGGATGCCGGCGTCACCGCAGGCTTGT
TCATGTATCCGGTGCTGATGGCGGCCGATATCCTGATCTTCAATGCGCACAAGGTGCCGGTAGGGCGTGACCAGATCCAG
CACATCGAAATGGCGCGCGATTTCGCGCAGCGTTTCAATCATGTCTACGGGCGCGACTTTTTCACCTTGCCCGAAGCGGT
GATCGACGAGCAGGTGTCCACCTTGCCAGGCCTGGATGGCCGCAAGATGAGCAAGAGCTATAGCAACACCATTCCACTGT
TTGCACCGCGCGAGGAATTGCGCAAGCTGGTGTTTTCCATCCTGACCGATTCGCGCGCGCCGGGCGAAGCCAAGGACACG
CAGGGGTCGGCGTTGTTTCAGCTGTACCAGGCGTTTGCCACACCGCAGGAATCTGCCGCCTTTGCGCAGGCGTTTGCCGA
CGGCATCGGCTGGGGCGATGCCAAGCAGCAGTTGTTCGAGCGGATCGATCAAGAGATTGCACCGCTGCGTATGCGCTACG
AGGCGTTGATGGCAGAGCCGGCCAAGATCGAAGCGATCCTGCGCGCCGGTGGTGCACGTCTGCGCGCGCGCTATGCCACC
CCCCTGCTGGCCGAGTTGCGCGACGCGGTGGGTTTGCGCGATCTGTCCAGCCAGGCCGCCACCGCGGCGGTGCAGGCCAG
CGAAAAGGTCGCACTGCCGGTGTTCAAGCAATATCGTGAAAGCGATGGGCAGTTCTATTTCAAGTTGAACGATGGCGCGG
GTGCATTGCTGCTGCAGAGCGATGGCTTCGCTTCGCCACGCGATGCCGGACAGGTGATCGCACGGTTGAAGCAGGCTACC
CAAGCCAGCGATCTGCAGCTGCCGGGCGTGCATGCGCAGGTGGATGCCGACGTGATTGTTGCCGCGATGGATGCCTTGCG
CGAGGCGTGA

Upstream 100 bases:

>100_bases
TTCTGCGTTCGAGCGTGGAGCCAACTCCCCGGCGCCTGCGGCGGTGGCAAAAGTGCGGAACCGCTAAACTTGGGGGCTAC
CCCACTCTGGCATGACGTAG

Downstream 100 bases:

>100_bases
GCTGCGCGGCGCAACAGGCGTCGAGGTGGGTTGTTGCGGTTGCGTAGGTCGTGCCTGTGGCGACATGCGCGACCGCGACG
CCAGGCTTGGGCCTACACTG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTTRVLTGITTSGTPHLGNYVGAIRPAIQASAGADTESFYFLADLHSLIKAQDPARTQRSTLEIAATWLACGLDPDKVWF
YRQSDVPETTELMWLLTCVAGKGILNRAHAYKAAVDKNRADGEDEDAGVTAGLFMYPVLMAADILIFNAHKVPVGRDQIQ
HIEMARDFAQRFNHVYGRDFFTLPEAVIDEQVSTLPGLDGRKMSKSYSNTIPLFAPREELRKLVFSILTDSRAPGEAKDT
QGSALFQLYQAFATPQESAAFAQAFADGIGWGDAKQQLFERIDQEIAPLRMRYEALMAEPAKIEAILRAGGARLRARYAT
PLLAELRDAVGLRDLSSQAATAAVQASEKVALPVFKQYRESDGQFYFKLNDGAGALLLQSDGFASPRDAGQVIARLKQAT
QASDLQLPGVHAQVDADVIVAAMDALREA

Sequences:

>Translated_429_residues
MTTRVLTGITTSGTPHLGNYVGAIRPAIQASAGADTESFYFLADLHSLIKAQDPARTQRSTLEIAATWLACGLDPDKVWF
YRQSDVPETTELMWLLTCVAGKGILNRAHAYKAAVDKNRADGEDEDAGVTAGLFMYPVLMAADILIFNAHKVPVGRDQIQ
HIEMARDFAQRFNHVYGRDFFTLPEAVIDEQVSTLPGLDGRKMSKSYSNTIPLFAPREELRKLVFSILTDSRAPGEAKDT
QGSALFQLYQAFATPQESAAFAQAFADGIGWGDAKQQLFERIDQEIAPLRMRYEALMAEPAKIEAILRAGGARLRARYAT
PLLAELRDAVGLRDLSSQAATAAVQASEKVALPVFKQYRESDGQFYFKLNDGAGALLLQSDGFASPRDAGQVIARLKQAT
QASDLQLPGVHAQVDADVIVAAMDALREA
>Mature_428_residues
TTRVLTGITTSGTPHLGNYVGAIRPAIQASAGADTESFYFLADLHSLIKAQDPARTQRSTLEIAATWLACGLDPDKVWFY
RQSDVPETTELMWLLTCVAGKGILNRAHAYKAAVDKNRADGEDEDAGVTAGLFMYPVLMAADILIFNAHKVPVGRDQIQH
IEMARDFAQRFNHVYGRDFFTLPEAVIDEQVSTLPGLDGRKMSKSYSNTIPLFAPREELRKLVFSILTDSRAPGEAKDTQ
GSALFQLYQAFATPQESAAFAQAFADGIGWGDAKQQLFERIDQEIAPLRMRYEALMAEPAKIEAILRAGGARLRARYATP
LLAELRDAVGLRDLSSQAATAAVQASEKVALPVFKQYRESDGQFYFKLNDGAGALLLQSDGFASPRDAGQVIARLKQATQ
ASDLQLPGVHAQVDADVIVAAMDALREA

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=336, Percent_Identity=33.0357142857143, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI41352700, Length=189, Percent_Identity=42.8571428571429, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1789786, Length=338, Percent_Identity=33.4319526627219, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71982800, Length=355, Percent_Identity=30.1408450704225, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71982793, Length=355, Percent_Identity=30.9859154929577, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320474, Length=344, Percent_Identity=30.5232558139535, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24666151, Length=339, Percent_Identity=30.3834808259587, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR010879
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 46800; Mature: 46668

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRVLTGITTSGTPHLGNYVGAIRPAIQASAGADTESFYFLADLHSLIKAQDPARTQRS
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
TLEIAATWLACGLDPDKVWFYRQSDVPETTELMWLLTCVAGKGILNRAHAYKAAVDKNRA
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
DGEDEDAGVTAGLFMYPVLMAADILIFNAHKVPVGRDQIQHIEMARDFAQRFNHVYGRDF
CCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
FTLPEAVIDEQVSTLPGLDGRKMSKSYSNTIPLFAPREELRKLVFSILTDSRAPGEAKDT
HHCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
QGSALFQLYQAFATPQESAAFAQAFADGIGWGDAKQQLFERIDQEIAPLRMRYEALMAEP
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AKIEAILRAGGARLRARYATPLLAELRDAVGLRDLSSQAATAAVQASEKVALPVFKQYRE
HHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
SDGQFYFKLNDGAGALLLQSDGFASPRDAGQVIARLKQATQASDLQLPGVHAQVDADVIV
CCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AAMDALREA
HHHHHHHCC
>Mature Secondary Structure 
TTRVLTGITTSGTPHLGNYVGAIRPAIQASAGADTESFYFLADLHSLIKAQDPARTQRS
CCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
TLEIAATWLACGLDPDKVWFYRQSDVPETTELMWLLTCVAGKGILNRAHAYKAAVDKNRA
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
DGEDEDAGVTAGLFMYPVLMAADILIFNAHKVPVGRDQIQHIEMARDFAQRFNHVYGRDF
CCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
FTLPEAVIDEQVSTLPGLDGRKMSKSYSNTIPLFAPREELRKLVFSILTDSRAPGEAKDT
HHCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
QGSALFQLYQAFATPQESAAFAQAFADGIGWGDAKQQLFERIDQEIAPLRMRYEALMAEP
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AKIEAILRAGGARLRARYATPLLAELRDAVGLRDLSSQAATAAVQASEKVALPVFKQYRE
HHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
SDGQFYFKLNDGAGALLLQSDGFASPRDAGQVIARLKQATQASDLQLPGVHAQVDADVIV
CCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AAMDALREA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]