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The map label for this gene is desK [H]

Identifier: 78049643

GI number: 78049643

Start: 4682165

End: 4683436

Strand: Reverse

Name: desK [H]

Synonym: XCV4087

Alternate gene names: 78049643

Gene position: 4683436-4682165 (Counterclockwise)

Preceding gene: 78049649

Following gene: 78049642

Centisome position: 90.44

GC content: 68.24

Gene sequence:

>1272_bases
ATGCATGAGGCCGCTCACCCGTATCGTCCTGCACGCAGCCGCACGCAGGCGGGCCCGGCAGTGGCAGAATCCGCTCATCC
ACACGGACCTTCGCTGATGCGCCCCCGGTTTCCCGCATGGCTTCGCCCCGCCGCCAGTTCGCAGGTTGCCGCGCGGCTGG
CGCAGGGCCAATCGCCGTGGATGGACAGCGTGCACCTGCTGTGGTCGGCCTGGGTATTCGTGGTGCCGGTGTTTTCTGCG
CGGGGCTACGACAGGACCTGGCTGTTGTGCACGCTGCTCTCGTATCCGGTTTTCCTGCTGCTGTACGCACGCATGTTGCT
GGCGCCACGCGGCACCTTGTATCGCTACGCCTGGGCGATGGCGGTGATGAGTGCCGCCTTGTTGCCGGTGTATTCGTCGG
GCATCAGCTACTTCATCTTTGCCTGCCTGAGCTTGCGTCCCTCCACGCGGCCTGGGTTGTGGCGGCACTTTGCGATGTTG
CTGCTGATGAATGCGTTGTACCTGAGCTGGGCGCACTGGCTCGGGTTGAGCATGCAGGCGCTGGTGTGGATGCCGGTGAC
GGTGCTGGGCATGGCCGCCGTGGGCGCGGTGTACAGCATCAACGAACGCAAGGACGCGTTGCTGCGCTTGTCGCAGGACG
AAGTTCGTCGTCTGGCGGCCACTGCCGAACGCGAGCGCATCGGCCGCGACCTGCACGATCTGCTTGGCCATACCTTGTCG
CTGGTGGCGCTCAAATCCGATCTGGCTGCGCGCCTGATCGAGCGCGACCCGCAGGCCGCACGCAACGAGATCGACGCGGT
GGCGCAGGTCTCGCGCGAGGCGTTGGCGCAGGTACGACGCGCGGTCACCGGCATCCGTGCTGCCGGCCTGGTTGCCGAAC
TGGCATCGGCGCGGGTGCTGCTGGACCTGGACGGCATTGCGCTGGAGCAACAGCTGGAGCCGCTGGCCTTGCCGCCCGAG
CACGAAACCGCGCTTGCGCTGGTGGTGCGCGAGGCGGCCACCAATGTGCAGCGCCACGCGCAGGCAAGACGCGTGCGTGT
GCAACTGCGCGCGCACGGCGATCAGGCCGTGCTGGAGATCACCGACGACGGCCGCGGCGGCGTGATCGTGCCGGGCAACG
GCCTGGACGGCATGCGCGCACGCCTGCACGGCCTGGGTGGCGCGCTGGATGTGCAGGCCTTGCCGCGCGGCATGCGATTG
CGCGCCAGTGTGCCGTTGCCGCGGCCTGCGGTTGTCCCCGCAACGCCGCCGGTGATGCCGCAGCCGCTCTAA

Upstream 100 bases:

>100_bases
TGCTTTCCTTTGCATTTGCAGACTGCACGTATCTGGCTTGCGCTTGCGCAGGCCAATCGCAACCCCGGTGGGCGATCGCA
TCGCAGCAAGCACCGGGAGC

Downstream 100 bases:

>100_bases
CGCGCCGTGGTTGCGCTGCCAAGTGCACGGCATGCGTCGGCGCTGTTATCGTGCGCAACCGTTGCATGCATGCGAGCGCG
ACCGATGATCCGGGTGTTGT

Product: two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MHEAAHPYRPARSRTQAGPAVAESAHPHGPSLMRPRFPAWLRPAASSQVAARLAQGQSPWMDSVHLLWSAWVFVVPVFSA
RGYDRTWLLCTLLSYPVFLLLYARMLLAPRGTLYRYAWAMAVMSAALLPVYSSGISYFIFACLSLRPSTRPGLWRHFAML
LLMNALYLSWAHWLGLSMQALVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVLLDLDGIALEQQLEPLALPPE
HETALALVVREAATNVQRHAQARRVRVQLRAHGDQAVLEITDDGRGGVIVPGNGLDGMRARLHGLGGALDVQALPRGMRL
RASVPLPRPAVVPATPPVMPQPL

Sequences:

>Translated_423_residues
MHEAAHPYRPARSRTQAGPAVAESAHPHGPSLMRPRFPAWLRPAASSQVAARLAQGQSPWMDSVHLLWSAWVFVVPVFSA
RGYDRTWLLCTLLSYPVFLLLYARMLLAPRGTLYRYAWAMAVMSAALLPVYSSGISYFIFACLSLRPSTRPGLWRHFAML
LLMNALYLSWAHWLGLSMQALVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVLLDLDGIALEQQLEPLALPPE
HETALALVVREAATNVQRHAQARRVRVQLRAHGDQAVLEITDDGRGGVIVPGNGLDGMRARLHGLGGALDVQALPRGMRL
RASVPLPRPAVVPATPPVMPQPL
>Mature_423_residues
MHEAAHPYRPARSRTQAGPAVAESAHPHGPSLMRPRFPAWLRPAASSQVAARLAQGQSPWMDSVHLLWSAWVFVVPVFSA
RGYDRTWLLCTLLSYPVFLLLYARMLLAPRGTLYRYAWAMAVMSAALLPVYSSGISYFIFACLSLRPSTRPGLWRHFAML
LLMNALYLSWAHWLGLSMQALVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVLLDLDGIALEQQLEPLALPPE
HETALALVVREAATNVQRHAQARRVRVQLRAHGDQAVLEITDDGRGGVIVPGNGLDGMRARLHGLGGALDVQALPRGMRL
RASVPLPRPAVVPATPPVMPQPL

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=228, Percent_Identity=27.1929824561404, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46335; Mature: 46335

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]