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The map label for this gene is norM [H]

Identifier: 78049495

GI number: 78049495

Start: 4521153

End: 4522529

Strand: Reverse

Name: norM [H]

Synonym: XCV3939

Alternate gene names: 78049495

Gene position: 4522529-4521153 (Counterclockwise)

Preceding gene: 78049497

Following gene: 78049494

Centisome position: 87.33

GC content: 68.34

Gene sequence:

>1377_bases
ATGTCTGTTTCTTCTGCACCCCCGTCCGCGACGCCAGGCTTCGCCTCGGAAGTGCGCACCACCGGCCTGCTTGCGTTGCC
GCTGGTGCTCGGCCACGTTTCCACCGGCCTGATCGGTTTTGTCGACAACGTCATCGCCGGCCACCACGGCACCGCCACGC
TGGCTGCAGTCACCATCGGCACCTCGCTGCTGTGGCTGCCGATGCTGGTGCCGATCGGCACCTTGATCTCGTTGACTGCC
TCGGTCTCGCAATTGCTCGGCGCCGGCCGCGAGCGCGAGATCGGGCCGCTGTTCCGGCAGGCGCTGTGGCTGTCGCTGGG
GCTGAGTGCGCTGATGTTCGTGTTCCTGAGCGTGGTGCCGCCGTTGCTGCCCACCTTCGGGATTGCAGCGGACATCGTGC
CCGGCGCGACCGCGTTCCTGCACGCGGTGCGCTGGGGCGTGCCGGCGCTGACCTTCTACTTCTGCATGCGCTATCTCAGC
GAGGGCATGCACTGGACGCTGCCGACCATGCTGCTGGGTTTTGGCGGCCTGCTGGTGCTGGCACCGGTGGGCTATGCGCT
GACCTATGGCAAGTTCGGCTTCGCCGAGCACGGTGCCGAAGGGCTGGGCATCGCCTCGGCCATCACCATGTGGGTGCAGG
CGAGCGTGTTTGCGCTGTATCTGTGGCGCGCACGGCGGTTTGCGCATCTGCACTTGTTCGCCCACCTGGAAGGACCGCGC
TGGCGCGCCATCGGCGAGTTGCTACGCACCGGCTTGCCGATCGGCATCACCGTGTTGATGGAAGGCGGGTTGTTTATCGT
CACTGCGTTGTTGATCGGCCGGCTGGGCGCCACCGAAGCGGCCGCGCACCAGATCGCGATCAACGTCGCGCAGTTGTGCT
TCATGATCCCGATGGGCGTGGCCGAGGCCACCACCGTGCGCGTGGGCCACGCAGTGGGCCGCGGCGACCCGCTGGCGATG
CGGCGCGCGGCCTGGGCCGGCTATGCGATCGTGCTGGGCACCCAAGCGCTGTCGGCCAGCGCACTGTTGCTGGGCCACGA
TGCCATCGTCGGCGTCTATACCGACGACGTGGCCGTGGCCGCGCTGGCGTCGGTGTTGCTGCTGTTTGCCGCCACGTTCC
AGTTTCCCGACGGCATCCAGGTGCTGTCGGCCGGCGCGCTGCGCGGGCTCAAGGACACCCGCGTGCCGATGTTCCTGGCG
ATGTTTTCGTACTGGGGCGTGGGCATGCCGATCGGCGCCGGGCTCGGCCTGGGGCTGGGCTGGGGACCGAAGGGCATGTG
GGTGGGCCTGATCCTGGGCCTGACGGTGGCCTCGATCCTGATGGGGCTGCGCTTCCGCCAGACCAGCCGGCGGCTGACCG
CCACCGTGACACCCTGA

Upstream 100 bases:

>100_bases
GCAAGGCCGCAGTCGGAAAGTAGGCGTAAGATAGCCGGCCCGCGCGACCCGGTGCCAGCGCCTCCCGGCACGGCCGTAGT
CCGCGCAGCGATCGGTTGTC

Downstream 100 bases:

>100_bases
CTTCCAGCGCATGCCGCGCGCGCTGCGCAGCCGGTATGCTGGGCACCATCGATCTGTATGCAGCGTCTTTCGACGGAGCT
TTCCATGAACCACCCCGTGC

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTA
SVSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAADIVPGATAFLHAVRWGVPALTFYFCMRYLS
EGMHWTLPTMLLGFGGLLVLAPVGYALTYGKFGFAEHGAEGLGIASAITMWVQASVFALYLWRARRFAHLHLFAHLEGPR
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGATEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPLAM
RRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLA
MFSYWGVGMPIGAGLGLGLGWGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP

Sequences:

>Translated_458_residues
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTA
SVSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAADIVPGATAFLHAVRWGVPALTFYFCMRYLS
EGMHWTLPTMLLGFGGLLVLAPVGYALTYGKFGFAEHGAEGLGIASAITMWVQASVFALYLWRARRFAHLHLFAHLEGPR
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGATEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPLAM
RRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLA
MFSYWGVGMPIGAGLGLGLGWGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP
>Mature_457_residues
SVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTAS
VSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAADIVPGATAFLHAVRWGVPALTFYFCMRYLSE
GMHWTLPTMLLGFGGLLVLAPVGYALTYGKFGFAEHGAEGLGIASAITMWVQASVFALYLWRARRFAHLHLFAHLEGPRW
RAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGATEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPLAMR
RAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLAM
FSYWGVGMPIGAGLGLGLGWGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=421, Percent_Identity=24.7030878859857, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI22907060, Length=425, Percent_Identity=27.2941176470588, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38261960, Length=454, Percent_Identity=23.3480176211454, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI48994890, Length=449, Percent_Identity=37.1937639198218, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI226510954, Length=223, Percent_Identity=26.0089686098655, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320545, Length=450, Percent_Identity=22.8888888888889, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48098; Mature: 47967

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
SVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TSLLWLPMLVPIGTLISLTASVSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLPTFGIAADIVPGATAFLHAVRWGVPALTFYFCMRYLSEGMHWTLPTMLLGFGGLLVL
HHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHH
APVGYALTYGKFGFAEHGAEGLGIASAITMWVQASVFALYLWRARRFAHLHLFAHLEGPR
HHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCH
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGATEAAAHQIAINVAQLCFMIPMGV
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
AEATTVRVGHAVGRGDPLAMRRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVA
CHHHHEEHHHHCCCCCHHHHHHHHHCCEEEEEECHHHHHHHHEEECCEEEEEECHHHHHH
ALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLAMFSYWGVGMPIGAGLGLGLG
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
WGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]