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The map label for this gene is cbs [H]

Identifier: 78049282

GI number: 78049282

Start: 4307861

End: 4309231

Strand: Reverse

Name: cbs [H]

Synonym: XCV3726

Alternate gene names: 78049282

Gene position: 4309231-4307861 (Counterclockwise)

Preceding gene: 78049283

Following gene: 78049281

Centisome position: 83.21

GC content: 62.8

Gene sequence:

>1371_bases
ATGGCGATTCATTCCTCCGTACTCGAACTGATTGGCAACACGCCGATCGTCAAGGCCCAGCGCCTGGACACCGGCGTCTG
CGAGCTGTTCCTCAAGCTGGAGGCGAATAATCCTGGCGGATCGATCAAGGACCGTATCGGTCTGTCGATGATCGAAGCGG
CCGAGCAGCGCGGCGATCTCAAGCCCGGCGCTACCCTGGTGGAGGGTACCGCCGGCAACACCGGTCTGGGCTTGGCCCTG
GTGGCGCAGCAGAAGGGCTACCAGTTGATCCTGGTGGTGCCGGACAAGATGAGCCGCGAGAAGATCTTCAATCTCAAGGC
CATGGGCGCCAACGTGGTGCTGACGCGCTCGGATGTGGCCAAGGGCCACCCCGAGTACTACCAGGACCTGGCTGCCAGGA
TCGCAGCCGAGACTCCCGGCGCCTACTTCATCAACCAGTTCGGCAACCCGGACAACCCGGCCGCGCACGAATTCGGCACC
GGCCCGGAAATCCTGGCGCAGATGGGCGGCCAACTGGACGCCATCGTGTTCGGTTGCGGCAGCTCCGGCACCATGACCGG
CCTGTCGCGCGCCTTCGCCAGCGCCTCGTCGCACACCGAACTGGTATTGGCCGACCCGGTCGGTTCGATCCTGACCCAAT
ACATCGAAGAGGGCACGGTCAGCGAAAAGTCCGGCAGCTGGTTGGTCGAAGGCATCGGCGAGGATTTCCTGCCGGATATC
TCCGACTTTTCGCGGGTCAAGAAGGCCTATTCCATCAGCGACGCGGAAAGCTTCCATACCGCGCGCGAGCTGCTGGCCAA
GGAGGGCATCCTCGGCGGCTCGTCCACCGGCACCCTGCTGGCCGCGGCGCTGAAGTATTGCCGCGAGCAGACCACGCCCA
AGCGCGTGCTGGTGTTCGTCTGCGATACCGGCAACAAGTATCTGTCGAAGATGTACAACGACTACTGGATGCTCGACAAC
GGCTTTTTGGAGCGCCCGCAACATGGCGATCTGCGCGACCTGATCCTGCGCCCTTACAACAAGCGCGACACCGTGGTGGT
GGGCCCGAAGGATCTGCTGACCACCGCCTACCAGCGCATGAAGCTGTACGACGTCTCGCAGTTGCCGGTGATCGATGAAG
GCGAGCTGGTGGGCATCGTGGACGAAAGCGACGTGCTGCTGCATGTCTATGGCGACGAAGCCCGTTTTCGCGACCCGATT
TCCACTGCCATGGTCAGCAAGCTGGATCGTCTGGACGTCGCGTCGCCGATCGAAGCGCTACTGCCGGTGTTCGACCGTGG
CCAGGTCGCCATCGTCATGGACGGCACGCAATTTCTTGGCTTGATCACCCGCATCGACCTGCTCAACTACCTGCGCCGTC
GCGTGCAGTGA

Upstream 100 bases:

>100_bases
TCATCGGCCTGTGCAATCGGTTCAATGCTGAATGAGCATTCCCCGGCGGTTCGTCGGATAATGACCGGTCTAGCCCGCGT
GGCGCAGCGACGATATCCCG

Downstream 100 bases:

>100_bases
TCGTGCAGTAATCCGGCACCGCCGCGCGCTCGGATGAGACGCGCGGCACGGGCCATTCAGACCTGCTTGTTACAATCGCC
CACTTTTTCGGGAACCTCCA

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAEQRGDLKPGATLVEGTAGNTGLGLAL
VAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGT
GPEILAQMGGQLDAIVFGCGSSGTMTGLSRAFASASSHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDN
GFLERPQHGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRMKLYDVSQLPVIDEGELVGIVDESDVLLHVYGDEARFRDPI
STAMVSKLDRLDVASPIEALLPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ

Sequences:

>Translated_456_residues
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAEQRGDLKPGATLVEGTAGNTGLGLAL
VAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGT
GPEILAQMGGQLDAIVFGCGSSGTMTGLSRAFASASSHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDN
GFLERPQHGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRMKLYDVSQLPVIDEGELVGIVDESDVLLHVYGDEARFRDPI
STAMVSKLDRLDVASPIEALLPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ
>Mature_455_residues
AIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAEQRGDLKPGATLVEGTAGNTGLGLALV
AQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGTG
PEILAQMGGQLDAIVFGCGSSGTMTGLSRAFASASSHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDIS
DFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDNG
FLERPQHGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRMKLYDVSQLPVIDEGELVGIVDESDVLLHVYGDEARFRDPIS
TAMVSKLDRLDVASPIEALLPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=472, Percent_Identity=35.3813559322034, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI295821200, Length=472, Percent_Identity=35.3813559322034, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI4557415, Length=472, Percent_Identity=35.3813559322034, Blast_Score=261, Evalue=1e-69,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=40.9090909090909, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=42.4342105263158, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=41.7682926829268, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=38.4146341463415, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=36.4516129032258, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=36.9281045751634, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=36.963696369637, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115535073, Length=345, Percent_Identity=36.231884057971, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=34.9673202614379, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=33.0357142857143, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996324, Length=343, Percent_Identity=27.1137026239067, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=23.546511627907, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=503, Percent_Identity=33.2007952286282, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6321449, Length=338, Percent_Identity=33.4319526627219, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24643623, Length=468, Percent_Identity=33.3333333333333, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129101, Length=468, Percent_Identity=33.3333333333333, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49607; Mature: 49476

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAEQRGDL
CCCHHHHHHHHCCCCCEEHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
KPGATLVEGTAGNTGLGLALVAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVA
CCCCEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHEECCCEEEEECCHHC
KGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGTGPEILAQMGGQLDAIVFGCG
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECC
SSGTMTGLSRAFASASSHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCH
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
CDTGNKYLSKMYNDYWMLDNGFLERPQHGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRM
ECCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KLYDVSQLPVIDEGELVGIVDESDVLLHVYGDEARFRDPISTAMVSKLDRLDVASPIEAL
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
LPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAEQRGDL
CCHHHHHHHHCCCCCEEHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
KPGATLVEGTAGNTGLGLALVAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVA
CCCCEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHEECCCEEEEECCHHC
KGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGTGPEILAQMGGQLDAIVFGCG
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECC
SSGTMTGLSRAFASASSHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCH
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
CDTGNKYLSKMYNDYWMLDNGFLERPQHGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRM
ECCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KLYDVSQLPVIDEGELVGIVDESDVLLHVYGDEARFRDPISTAMVSKLDRLDVASPIEAL
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
LPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]