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The map label for this gene is metC [H]

Identifier: 78049281

GI number: 78049281

Start: 4306574

End: 4307761

Strand: Reverse

Name: metC [H]

Synonym: XCV3725

Alternate gene names: 78049281

Gene position: 4307761-4306574 (Counterclockwise)

Preceding gene: 78049282

Following gene: 78049280

Centisome position: 83.19

GC content: 64.31

Gene sequence:

>1188_bases
ATGTCCAATCGCACCACTCATAGCCATGACGGCGAGCGCGCGCTGTCGCTCGCAACGCTGGCGATCCATGGAGGGCAGTC
GCCAGATCCGAGCACCGGCGCGGTAATGCCGCCGATCTATGCGACGTCCACCTATGCGCAGTCCAGCCCCGGCGAGCACC
AGGGCTTCGAATATTCGCGCACCCACAACCCCACGCGCTTCGCCTACGAGCGTTGCGTTGCCGCGCTGGAAGGCGGTACG
CGCGCATTTGCGTTCGCTTCCGGCATGGCTGCCACCTCGACGGTGATGGAGTTGCTGGATGCCGGCAGCCACGTGGTGGC
GATGGACGACCTGTACGGCGGCACCTTCCGCCTGTTCGAGCGCGTGCGCCGTCGCACCGCCGGCCTGGATTTCAGCTTCG
TCGACCTGACCGACCCGGCCGTTTTCGAAGCTGCAATCCGCCCCGATACCAAGATGGTGTGGATCGAAACCCCGACCAAC
CCGATGCTCAAGCTGGTCGATATCGCTGCCATTGCCGCGATCGCGCGCAAGCACGGCCTGTTGATCGTGGTCGACAACAC
GTTCGCTTCCCCGATGCTGCAGCGCCCGCTCAGCCTGGGTGCGGATATCGTCGTGCACTCGGCCACCAAGTATCTCAACG
GCCACTCGGACATGGTCGGCGGCATCGCGGTGGTTGGCGACAACGCCGAGCTCGCCGAGCAGATGGCGTTCCTGCAGAAC
TCCATCGGCGGCGTCCAGGGCCCGTTCGACAGCTTCCTCGCCCTGCGCGGCCTCAAGACCCTGCCGCTGCGCATGCGCGC
GCATTGCGAGAATGCCCTGGCGCTCGCGCAATGGCTGGAAACCCACCCTGCGATCGAAAAGGTCATTTACCCCGGCCTTG
CTTCGCACCCGCAGCATGCGCTCGCGAAAACCCAGATGTCCGGCTTCGGCGGCATCGTCTCCATTGTCCTCAAGGGCGGC
TTCGACGCAGCCAAGCGTTTCTGCGAAAAGACCGAATTGTTCACCCTGGCCGAATCGCTCGGTGGCGTGGAAAGCCTGCT
CAACCATCCCGCCGTCATGACCCACGCCTCCATTCCGGTTGCCCGCCGTGACCAGCTTGGTATCAGCGATGCGCTGGTGC
GGTTGAGCGTGGGGATTGAAGATGTGGGGGATTTGCGTGGGGATTTGGAGTGGGCGCTTGCGCGTTAA

Upstream 100 bases:

>100_bases
ATCGTGCAGTAATCCGGCACCGCCGCGCGCTCGGATGAGACGCGCGGCACGGGCCATTCAGACCTGCTTGTTACAATCGC
CCACTTTTTCGGGAACCTCC

Downstream 100 bases:

>100_bases
GCAGCACATCCACGTAACGGAAACCTGGCGCTCATCGCGCGGCTTGGCAGTGGCCAAATGAAGGCGCGCACGTCGCGAGT
TTTGCCGAGCACCGGGTTTC

Product: Cys/Met metabolism PLP-dependent enzyme

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGT
RAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAVFEAAIRPDTKMVWIETPTN
PMLKLVDIAAIAAIARKHGLLIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHALAKTQMSGFGGIVSIVLKGG
FDAAKRFCEKTELFTLAESLGGVESLLNHPAVMTHASIPVARRDQLGISDALVRLSVGIEDVGDLRGDLEWALAR

Sequences:

>Translated_395_residues
MSNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGT
RAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAVFEAAIRPDTKMVWIETPTN
PMLKLVDIAAIAAIARKHGLLIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHALAKTQMSGFGGIVSIVLKGG
FDAAKRFCEKTELFTLAESLGGVESLLNHPAVMTHASIPVARRDQLGISDALVRLSVGIEDVGDLRGDLEWALAR
>Mature_394_residues
SNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTR
AFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAVFEAAIRPDTKMVWIETPTNP
MLKLVDIAAIAAIARKHGLLIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNS
IGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHALAKTQMSGFGGIVSIVLKGGF
DAAKRFCEKTELFTLAESLGGVESLLNHPAVMTHASIPVARRDQLGISDALVRLSVGIEDVGDLRGDLEWALAR

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=55.6164383561644, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=50.4109589041096, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=48.6263736263736, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI1790375, Length=374, Percent_Identity=45.1871657754011, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1789383, Length=396, Percent_Identity=30.050505050505, Blast_Score=167, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=52.5885558583106, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=50.9536784741144, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71980708, Length=381, Percent_Identity=38.3202099737533, Blast_Score=248, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6319307, Length=389, Percent_Identity=47.8149100257069, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=34.6534653465347, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323333, Length=430, Percent_Identity=34.8837209302326, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=324, Percent_Identity=32.0987654320988, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=30.4020100502513, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322970, Length=238, Percent_Identity=25.6302521008403, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322590, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922554, Length=381, Percent_Identity=49.0813648293963, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42344; Mature: 42213

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSR
CCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
THNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFE
CCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHH
RVRRRTAGLDFSFVDLTDPAVFEAAIRPDTKMVWIETPTNPMLKLVDIAAIAAIARKHGL
HHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCE
LIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
EEEECCCCCCHHHHHHHHCCCHHEEEHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHH
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHA
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LAKTQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLLNHPAVMTHASIPV
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCC
ARRDQLGISDALVRLSVGIEDVGDLRGDLEWALAR
CCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSR
CCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
THNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFE
CCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHH
RVRRRTAGLDFSFVDLTDPAVFEAAIRPDTKMVWIETPTNPMLKLVDIAAIAAIARKHGL
HHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCE
LIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
EEEECCCCCCHHHHHHHHCCCHHEEEHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHH
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHA
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LAKTQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLLNHPAVMTHASIPV
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCC
ARRDQLGISDALVRLSVGIEDVGDLRGDLEWALAR
CCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]