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The map label for this gene is rmlA [H]

Identifier: 78049264

GI number: 78049264

Start: 4283750

End: 4284637

Strand: Reverse

Name: rmlA [H]

Synonym: XCV3708

Alternate gene names: 78049264

Gene position: 4284637-4283750 (Counterclockwise)

Preceding gene: 78049265

Following gene: 78049263

Centisome position: 82.74

GC content: 60.02

Gene sequence:

>888_bases
ATGACACAACGCAAAGGCATCATCCTGGCAGGCGGCTCCGGCACCCGCCTGTATCCAATCACCAAGGGCGTCAGCAAGCA
GCTGCTGCCGGTGTACGACAAGCCGATGATCTATTACCCGCTCAGCGTGCTGATGCTGGCGGGCATCCGCGACATCCTGA
TCATCAACACACCGCACGAGCAGGCGCTGTTCCAGTCGTTGCTGGGCGATGGTTCGCAATGGGGTGTCAATATCCAGTAC
GCCGTGCAACCGAGTCCAGACGGGCTCGCGCAGGCGTATCTGATCGGCCGCGACTTCGTGGACGGCAAGCCGAGCTGCCT
GGTGTTGGGCGACAACATCTTCCACGGTCATGGCCTGACCGAGACCCTGCGCCGCGCCGATGCGCGTGAACAGGGGGCGA
CCGTGTTCGGTTACTGGGTCAACGACCCGGAGCGCTACGGCGTTGCCGAATTCGATCAGCAGGGCAAGGTGATCGATATC
GCCGAAAAGCCTGAGAAGCCCCGTTCGAACTATGCGGTAACGGGTTTGTATTTCTACGATGGAAGAGCAAGCGACTATGC
GGCTGCCCTGAAGCCATCGCCGCGCGGCGAATTGGAGATCACCGACCTCAATCGCTGCTATCTGGAAGCCGGCAAGCTGC
ATCTCGAGCCGCTAGGGCGTGGCTATGCGTGGCTTGATACCGGTACGCATCAGTCCTTGCATGAAGCGGCCAACTTCATC
GAAACCATCCAGATGCGGCAGGGTCTGCAGGTGTGCTGTCCTGAGGAAATCGCATTTGGTCAGGGCTGGATCGACACCGA
ACAGCTGGAGCGCCTTGCGGCGCCGCTGGCTAAAAATGACTACGGTAAGTATCTAAACGCCCTAGCCAAGCGCGGAGTGG
TCCGTTGA

Upstream 100 bases:

>100_bases
CTGGACGGAAGCTACCGTCTGGAACGTATCGGCGCGGCGTCCTGACATCCCTCTCTCTGGTGGCCGCTCAGGTGCGTGCC
GACCTTCCAAGGAAGCTCTC

Downstream 100 bases:

>100_bases
AAGTGATCGAAACGACGTTGCCTGGCTGCGTTGTGATAGAGCCATCAGTCTTTGGAGATGCTAGGGGATACTTCTTCGAA
ACGTGGAATGCCGAGCGTTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHEQALFQSLLGDGSQWGVNIQY
AVQPSPDGLAQAYLIGRDFVDGKPSCLVLGDNIFHGHGLTETLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDI
AEKPEKPRSNYAVTGLYFYDGRASDYAAALKPSPRGELEITDLNRCYLEAGKLHLEPLGRGYAWLDTGTHQSLHEAANFI
ETIQMRQGLQVCCPEEIAFGQGWIDTEQLERLAAPLAKNDYGKYLNALAKRGVVR

Sequences:

>Translated_295_residues
MTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHEQALFQSLLGDGSQWGVNIQY
AVQPSPDGLAQAYLIGRDFVDGKPSCLVLGDNIFHGHGLTETLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDI
AEKPEKPRSNYAVTGLYFYDGRASDYAAALKPSPRGELEITDLNRCYLEAGKLHLEPLGRGYAWLDTGTHQSLHEAANFI
ETIQMRQGLQVCCPEEIAFGQGWIDTEQLERLAAPLAKNDYGKYLNALAKRGVVR
>Mature_294_residues
TQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHEQALFQSLLGDGSQWGVNIQYA
VQPSPDGLAQAYLIGRDFVDGKPSCLVLGDNIFHGHGLTETLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDIA
EKPEKPRSNYAVTGLYFYDGRASDYAAALKPSPRGELEITDLNRCYLEAGKLHLEPLGRGYAWLDTGTHQSLHEAANFIE
TIQMRQGLQVCCPEEIAFGQGWIDTEQLERLAAPLAKNDYGKYLNALAKRGVVR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=255, Percent_Identity=23.1372549019608, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI11761619, Length=255, Percent_Identity=23.1372549019608, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=68.2758620689655, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=64.3356643356643, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788355, Length=240, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=190, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=193, Percent_Identity=30.0518134715026, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355443, Length=182, Percent_Identity=23.6263736263736, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24644084, Length=182, Percent_Identity=23.6263736263736, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32691; Mature: 32559

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHE
CCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCHH
QALFQSLLGDGSQWGVNIQYAVQPSPDGLAQAYLIGRDFVDGKPSCLVLGDNIFHGHGLT
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEEECCCCCCCCCEEEEECCEEECCCHH
ETLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDIAEKPEKPRSNYAVTGLYFYD
HHHHHHHHHHCCCEEEEEECCCHHHCCCCHHCCCCCEEEECCCCCCCCCCEEEEEEEEEC
GRASDYAAALKPSPRGELEITDLNRCYLEAGKLHLEPLGRGYAWLDTGTHQSLHEAANFI
CCCCCCEEECCCCCCCCEEEEECHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHHHH
ETIQMRQGLQVCCPEEIAFGQGWIDTEQLERLAAPLAKNDYGKYLNALAKRGVVR
HHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHE
CCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCHH
QALFQSLLGDGSQWGVNIQYAVQPSPDGLAQAYLIGRDFVDGKPSCLVLGDNIFHGHGLT
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEEECCCCCCCCCEEEEECCEEECCCHH
ETLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDIAEKPEKPRSNYAVTGLYFYD
HHHHHHHHHHCCCEEEEEECCCHHHCCCCHHCCCCCEEEECCCCCCCCCCEEEEEEEEEC
GRASDYAAALKPSPRGELEITDLNRCYLEAGKLHLEPLGRGYAWLDTGTHQSLHEAANFI
CCCCCCEEECCCCCCCCEEEEECHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHHHH
ETIQMRQGLQVCCPEEIAFGQGWIDTEQLERLAAPLAKNDYGKYLNALAKRGVVR
HHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]