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The map label for this gene is gltP [H]

Identifier: 78049047

GI number: 78049047

Start: 3998442

End: 3999770

Strand: Reverse

Name: gltP [H]

Synonym: XCV3491

Alternate gene names: 78049047

Gene position: 3999770-3998442 (Counterclockwise)

Preceding gene: 78049048

Following gene: 78049046

Centisome position: 77.24

GC content: 63.96

Gene sequence:

>1329_bases
ATGGCGTTTGTTAAGCTCCGGTCTTTGTGTCCACCAAGGCCTGACCAGATGACAGTATCCCCAGCCACGCGCCGTCCGGG
CCTGCCCCTGCATTGGAAGATGGGAATTGGCTTTGCCGTTGGCCTGTTGTTGGGCCTGGCTGTCTATTACCTGGCCGGCA
GCGACGCCGAGTGGGTGCGCCTGGCGACCAAGTACGTCGCCACGCCGTTTTCGCAGGTCTTCCTCAATCTGATCTTCATG
CTGATCGTGCCGCTGCTGTTCTCGGCGCTGGTCATGGGCATTTCCGAAATGGGCGACATCCGCGCGCTCGGGCGGGTGGG
GTGGCGCACCCTGGGCTATACCGTGGTGCTGTCCGGTGTGGCGGTGCTGCTGGGGCTGGTGCTGGTCAACGTGCTCAAGC
CCGGTGCGGGCGTGGACCCGCAACTGGCCAATCAGCTGATCCAGGAAAACGCCGAGCGCACCCGCGAGATCATTTCCAGC
TCCGGCACGCAGCCGCAGGGCATGGACATGCTGCTGTCGATCGTGCCCAGCAACGTGATTGCCGCCGCGTCGAGCAACGG
CGCGATTCTGTCGCTGATGTTTTTTGCGGTGATGTTCGGCGTGGGCATGGTGCTGACCGAAGACGAAAAGGTCGCCACAT
TGCGGCGCGGCATCGAAGGGGTCTTCGAGATTTCGATGACCTTGATCGGGCTGGTGATCCGCCTGGCGCCGTATGCGGTG
GCGTGTTTCATGTTCAACCTGGCCGCGCTGTTCGGCTTCGATCTGCTGATTCGTCTGGGCGCCTACGTGGGCGTAGTGGT
GTTGGCGCTGGGCCTGCACATGGTGGTCAGTTACGGCATTGCGGTGAAATTCGCCGGACGCTCGCCGCTGGGCTTTTTCC
GCCAGACCCAGGAAGCGACGGTGATGGCGTTCTCGACCGCGTCCAGCAACGCAACCCTGCCGACGGCGCTACGCGTGGCC
GACGAGATGGGCCTGCCGCCGCGCGTGTCGCGTTTCGTGCTGACCGTTGGCGCCACCGCCAACCAGAACGGAACCGCACT
CTTCGAAGGCGTCACGGTGATCTTCCTGGCACAGTTCTTCAACGTGGACCTGAGCCTGGGCCAGCAGTTCATGGTGATGC
TGGTCTGCATCCTGGGCGGGATCGGCACGGCCGGCGTGCCGTCCGGCTCGCTGCCGGTGGTGGCGCTGATCTGCGCGATG
GTCGGGGTCAACCCGGTGGGTATCGGCATGATCCTGGGCGTCAACCACTTCCTGGACATGTGCCGCACGGCGCTGAACGT
GACCGGGGATCTGGCGCTGACGACCTTGGTGGCCAAGGGCGAAGAGTAG

Upstream 100 bases:

>100_bases
AACTCCTACCGCCAACTGCAAAACGCTGCCTCACCCGACAGCGAGAAGCTCGCCTACCCGCACAAGGCATATAGCAGCAC
CCGGGTAGGTGGCCGCATCC

Downstream 100 bases:

>100_bases
GGATTTGGGAGTCAGGATTGGGGATTCGCTAAAGCGGGCTGTTGCGATCGTGTGGTGCCATCGGGCCTTCCTGGATGAAG
GTCAGGTCGCCCGTGCCTTC

Product: glutamate/aspartate:cation symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MAFVKLRSLCPPRPDQMTVSPATRRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVRLATKYVATPFSQVFLNLIFM
LIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISS
SGTQPQGMDMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLGFFRQTQEATVMAFSTASSNATLPTALRVA
DEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAM
VGVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE

Sequences:

>Translated_442_residues
MAFVKLRSLCPPRPDQMTVSPATRRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVRLATKYVATPFSQVFLNLIFM
LIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISS
SGTQPQGMDMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLGFFRQTQEATVMAFSTASSNATLPTALRVA
DEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAM
VGVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE
>Mature_441_residues
AFVKLRSLCPPRPDQMTVSPATRRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVRLATKYVATPFSQVFLNLIFML
IVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISSS
GTQPQGMDMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAVA
CFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLGFFRQTQEATVMAFSTASSNATLPTALRVAD
EMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMV
GVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=437, Percent_Identity=29.5194508009153, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI40254478, Length=478, Percent_Identity=29.0794979079498, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI21314632, Length=409, Percent_Identity=28.1173594132029, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI66773030, Length=446, Percent_Identity=26.2331838565022, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI169790839, Length=413, Percent_Identity=27.1186440677966, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI194239697, Length=423, Percent_Identity=25.0591016548463, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=28.9817232375979, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI301601644, Length=156, Percent_Identity=35.8974358974359, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=30.6772908366534, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI262359914, Length=351, Percent_Identity=26.2108262108262, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790514, Length=419, Percent_Identity=34.6062052505967, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=28.9156626506024, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1788024, Length=434, Percent_Identity=26.2672811059908, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789473, Length=226, Percent_Identity=26.5486725663717, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=401, Percent_Identity=29.6758104738155, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=28.7610619469027, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=399, Percent_Identity=30.8270676691729, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=414, Percent_Identity=28.2608695652174, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=414, Percent_Identity=28.2608695652174, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=405, Percent_Identity=28.641975308642, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=441, Percent_Identity=26.0770975056689, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24583025, Length=442, Percent_Identity=29.8642533936652, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17137668, Length=442, Percent_Identity=29.8642533936652, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583023, Length=442, Percent_Identity=29.8642533936652, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI281360481, Length=417, Percent_Identity=23.5011990407674, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281360483, Length=417, Percent_Identity=23.5011990407674, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137666, Length=417, Percent_Identity=23.5011990407674, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46781; Mature: 46650

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFVKLRSLCPPRPDQMTVSPATRRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVR
CCCEEHHHCCCCCCCCEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHH
LATKYVATPFSQVFLNLIFMLIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISSSGTQPQGMDMLLSIVPSNVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHE
AAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLGFFRQTQEAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCHHHHHHCCCCE
VMAFSTASSNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFF
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHH
NVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDM
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTALNVTGDLALTTLVAKGEE
HHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AFVKLRSLCPPRPDQMTVSPATRRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDAEWVR
CCEEHHHCCCCCCCCEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHH
LATKYVATPFSQVFLNLIFMLIVPLLFSALVMGISEMGDIRALGRVGWRTLGYTVVLSGV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLGLVLVNVLKPGAGVDPQLANQLIQENAERTREIISSSGTQPQGMDMLLSIVPSNVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHE
AAASSNGAILSLMFFAVMFGVGMVLTEDEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLHMVVSYGIAVKFAGRSPLGFFRQTQEAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCHHHHHHCCCCE
VMAFSTASSNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFF
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHH
NVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDM
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTALNVTGDLALTTLVAKGEE
HHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]