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The map label for this gene is tktA [H]

Identifier: 78049046

GI number: 78049046

Start: 3996236

End: 3998236

Strand: Reverse

Name: tktA [H]

Synonym: XCV3490

Alternate gene names: 78049046

Gene position: 3998236-3996236 (Counterclockwise)

Preceding gene: 78049047

Following gene: 78049045

Centisome position: 77.21

GC content: 64.77

Gene sequence:

>2001_bases
ATGACCCAGCCCACCCGCCGCCAGCTGGCCAACGCCATCCGTTTTCTTGCCGCAGACGCGGTCGAAGCCGCCAAGTCCGG
TCATCCCGGCATGCCGATGGGCATGGCCGATATCGCCGAAGTGCTGTGGAACGACTTCTACCGGCACAACCCGAACAACC
CGCAGTGGTTCAACCGCGACCGCTTCGTGCTCTCCAACGGCCACGGTTCGATGCTGCAGTACGCGCTGTTGCACCTGTCC
GGCTACGACCTGCCGATCGAGCAGCTCAAGCAGTTCCGCCAGTTGCATAGCAAGACCGCCGGCCACCCCGAGCGCAGCGA
AACTCCCGGCGTGGAAACCACCACTGGTCCGCTCGGCCAGGGCTTCGCCAATGCGGTCGGTTTCGCGTTGGCCGAGAAGT
TGCTGGCGCAGCGCTACAACCGCCCGGAGCTGGAAATCGTCGATCACCGCACCTGGGTGTTCATGGGCGACGGCTGCCTG
ATGGAGGGCATTTCGCACGAAGCCGCATCGCTGGCCGGTACCTGGGGCCTGGGCAAGCTGGTGGCGTTCTGGGACAACAA
CCAGATTTCCATCGACGGCAATACGGCCGGCTGGTTCAGCGACGACACCCCGGCGCGTTTCGAGGCCTATGGCTGGCACG
TGATCCGCGATGTGGACGGGCATGACGCCGACAAGATCAAGGCCGCCATCGAGGCGGCGCTGGAAAACACCGACAAGCCC
ACGCTGATCTGCTGCCGTACCAAGATCGGCTTCGGTGCGCCGACCAAGGCCGGCAAGGAATCCTCGCATGGCGCGCCGCT
GGGCAAGGACGAACTGGAAGGCGCCCGCAAGGCGTTGGAATGGCCGTACGGCCCGTTCGAAATTCCCGAAGAGATCTACG
CCGGCTGGCGTGCCGGCGGTACCGGTACCTTGCGTCAGGCTGAATGGGAACAGCTGTTCGACAAGTATGCCAAGCAGTAC
GCCAGCGAAGCCGACGAGCTGACCCGTCGCTCGCACGGCGAGTTGCCGGCCGACTTCATCGCCAAGGCCGATGCCTACAT
CGCCAAGGCGCAGGAAGAGGGCCAGACCATTGCCTCGCGCAAGGCTTCGCAGCTGGCGATTGAAGCGTTTGCCCCGCTGC
TGCCGGAGTTGATCGGTGGTTCGGCCGACCTGGCGCACTCCAACCTGACCTTGTGGAAGGCCAGCAAGTCGGTCGCCACC
GACGACCCGGATGCCAACTACGTGTACTACGGTGTGCGCGAGTTCGGCATGACCGCCATTGCCAACGGTCTGGCGCTGCA
TGGCGGGTTCATTCCCTTCGACGCCACCTTCCTGGTGTTCAGCGACTACGCACGCAACGGCGTGCGCATGAGCGCGTTGA
ACCCGGCGCATGCGATTCATGTGTACACGCATGACTCGATCGGCCTGGGCGAGGACGGCCCGACCCATCAGCCGGTGGAA
CACCTGGCATCGCTGCGCTACATCCCCAACAACGATGTGTGGCGCCCGGGCGATGCGGTGGAATCGGCAGTGAGCTGGAA
GGCGGCCATTACCCGCAAGGACGGCCCGAGCTGCCTGATCTTCAGCCGTCAGAACCTGCAGCATCAGCCGCGCAGCGCCG
AGCAGATCAAGTTGATCGAACGCGGTGGTTACGTGCTGGCCGATGCCCAAGGCGGTACGCCGGACGTGATCCTGATCGCC
ACCGGCTCGGAAGTGGGCCTGGCGGTGGAAGCCAAGCAGACGCTGGATGCGGCCGGCCTAAAGACGCGCGTGGTGTCGAT
GCCGTCGACCGATGTGTTCGACCGCCAGGATGCGGCCTATCGCGACTCGGTGTTGCCGAATGCCGTGCGCAAGCGCGTGG
CGGTGGAAGCGGGCGTGACCGGCTTCTGGCGCAAGTACGTCGGCCTGGATGGCGATGTCGTCGGCATGGATACCTTCGGC
GCCTCGGCACCGGCCGATCAGCTGTATGCGTACTTCAAGATCACTGCCGAGCACGTGGTGGCCGCAGCGAAGGCGCTGTA
G

Upstream 100 bases:

>100_bases
TCCCGATTCTCCAATCACCAATCCCGGCCCCCTAACGCTGTGTATGGGAGAATAGGGGTCTCCGCTTCCAGCGGTGTTCC
CTCCGCTTCCATAGACGCCC

Downstream 100 bases:

>100_bases
CGCGCTGATAAGAGTCACAAAGACGCCGGCGAAAGCCGGCGTTTTTGTTTGTGGCGGATGTCCCAACGCGCCGCGTTTCG
CGCACTCGCGGTGCGATGTC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
GYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCL
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENTDKP
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQY
ASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVAT
DDPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQIKLIERGGYVLADAQGGTPDVILIA
TGSEVGLAVEAKQTLDAAGLKTRVVSMPSTDVFDRQDAAYRDSVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFG
ASAPADQLYAYFKITAEHVVAAAKAL

Sequences:

>Translated_666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
GYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCL
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENTDKP
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQY
ASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVAT
DDPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQIKLIERGGYVLADAQGGTPDVILIA
TGSEVGLAVEAKQTLDAAGLKTRVVSMPSTDVFDRQDAAYRDSVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFG
ASAPADQLYAYFKITAEHVVAAAKAL
>Mature_665_residues
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLSG
YDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLM
EGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENTDKPT
LICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQYA
SEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATD
DPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVEH
LASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQIKLIERGGYVLADAQGGTPDVILIAT
GSEVGLAVEAKQTLDAAGLKTRVVSMPSTDVFDRQDAAYRDSVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFGA
SAPADQLYAYFKITAEHVVAAAKAL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=27.7591973244147, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=27.7591973244147, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI133778974, Length=584, Percent_Identity=26.3698630136986, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI225637463, Length=575, Percent_Identity=22.6086956521739, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI225637459, Length=275, Percent_Identity=25.0909090909091, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=65.558912386707, Blast_Score=896, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=62.2154779969651, Blast_Score=850, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=26.3001485884101, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=676, Percent_Identity=47.189349112426, Blast_Score=558, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=43.4131736526946, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45551847, Length=686, Percent_Identity=25.5102040816327, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45550715, Length=686, Percent_Identity=25.5102040816327, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24666278, Length=582, Percent_Identity=25.2577319587629, Blast_Score=148, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=25.2321981424149, Blast_Score=135, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72505; Mature: 72374

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSGYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENTDKP
EEEECCCEEEECCCCCCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYAKQYASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATDDPDANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCHHEEEEEHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQIKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCHHHHHHEE
RGGYVLADAQGGTPDVILIATGSEVGLAVEAKQTLDAAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCCCCCCCCHHH
RDSVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFGASAPADQLYAYFKITAEHVV
HHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHEEEHHHHHH
AAAKAL
HHHHCC
>Mature Secondary Structure 
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFYRHNPNNPQWFNRD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSGYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDDTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENTDKP
EEEECCCEEEECCCCCCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYAKQYASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATDDPDANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCHHEEEEEHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLIFSRQNLQHQPRSAEQIKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCHHHHHHEE
RGGYVLADAQGGTPDVILIATGSEVGLAVEAKQTLDAAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCCCCCCCCHHH
RDSVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGMDTFGASAPADQLYAYFKITAEHVV
HHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHEEEHHHHHH
AAAKAL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]