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The map label for this gene is lysA [H]

Identifier: 78048612

GI number: 78048612

Start: 3479636

End: 3482245

Strand: Reverse

Name: lysA [H]

Synonym: XCV3056

Alternate gene names: 78048612

Gene position: 3482245-3479636 (Counterclockwise)

Preceding gene: 78048615

Following gene: 78048611

Centisome position: 67.24

GC content: 66.28

Gene sequence:

>2610_bases
ATGTCAGCTCCCCACTCTACCGATCGTTGGATCGTCCTCAAGTTCGGCGGCACTTCGGTGTCGCGTCGTCATCGCTGGGA
CACGATTGGAAAACTGGCGGGCAAACGGGCGCACGAGACCGGCGGTCGCGTGCTGGTGGTGGTGTCTGCATTGTCGGGCG
TGACCAACGAGCTCACCGCCATTGCCGACGGCGCCGCCGATAGCGCACAGCGCGTGGCGGCACTGGACCAACGCCATCGT
GAGTTTCTGGCCGAGCTCGAACTGGACGCCGATGCGGTGCTGGGCGAGCGACTGGCCGCACTGCATGCGTTGCTGGGCGA
CGCGCGCGCTGCAATGCGCACGCTGGACTGGCAGGCCGAGGTGCTGGGGCAGGGCGAGTTGCTGTCGTCCACCATCGGTG
CGGCGTACCTGCATGCCAGCGGCCTGGACATGGGCTGGCTGGATGCGCGCCAATGGCTGTCGGCGCCGCCCCCGCAGCCG
AATCAGAGCGAGTGGTCCAAGCGGCTGTCGGTGTCGTGCCAGTGGCAGTCCGATGCCGATTGGCGCACGCGTTTCGCCGC
GCAACCGACACGCTTGCTGATCACGCAAGGCTTCATTTCGCGTCATGCCGATGGCGGCACCGCGATTCTGGGCCGTGGCG
GTTCGGATACCTCGGCGGCGTACTTCGGTGCGCTGCTCGGCGCCAGCCGCGTGGAAATCTGGACCGATGTGCCCGGCATG
TTCAGCGCCAACCCGAAGGAAGTGCCGGACGCGCGGCTGCTGACCCGGCTGGACTATTACGAAGCGCAGGAAATCGCCAC
CACCGGCGCCAAGGTGCTGCATCCGCGTTCGATCAAGCCGTGTCGCGACTCCGGCGTGCCGATGGCGATCCTGGACACCG
AGCGCCCCGATCTGCCGGGCACCAGCATCGACGGCAATGCCGAACCGGTGTTGGGCGTCAAGGCGATCAGCCGCCGCAAC
GGCATCGTGCTGGTGTCGATGGAAGGTATCGGCATGTGGCAGCAGGTCGGCTTCCTGGCCGACGTGTTCACGCTGTTCAA
GAAGCATGGCCTGTCGGTGGATCTGATCGGTTCGGCCGAGACCAACGTCACCGTGTCGCTGGATCCTTCGGAAAACCTGG
TCAACACCGACGTGCTGGCGGCGTTGTCGGCCGATCTGTCGCAGATCTGCAAGGTCAAGATCATCGTTCCTTGCGCGGCC
ATCACCCTGGTCGGGCGCGGCATGCGTTCGCTGCTGCACAAGCTCTCCGACGTGTGGGCCACGTTCGGGCAGGAGCGCGT
GCACATGATTTCGCAGTCGTCCAACGACTTGAACCTGACCTTCGTCATCGACGAAGCCGATGCCGACGGTTTGCTGCCGA
TCCTGCATGCCGAACTGATCGACAGCGGTGCAATGCCGGTCAGCGAGGGCGAGGTGTTCGGCCCGCGCTGGCGGCAGATC
ATCGGCTCGGTACGTCCGCGTCCCACGCCGTGGTGGCATGCCGAGCGCGCGCATCTGCTGTCGCTGTCCAAGGCCGGGAC
GCCGCGTTACGCGTACCACCTGCCCACGGTGCGTGCGCGTGCGCATGCGCTGGCGCAGATTGCCGCGGTGGATCAGCGCT
ATTACGCGATCAAAGCCAACGCGCATCCGGCCATCTTGATGGCGCTGGAACAGGCCGGCTTCGGGCTGGAGTGCGTCTCG
CACGGCGAATTGCGCCGCGTCTTCCAGACGCTGCCGGAGTTGTCGCCGCGGCGCGTGCTGTTCACGCCGAGCTTTGCGCC
CAAGGCCGAATACGAGGCGGCCTTCGCGCTGGGCGTGACGGTGACCGTGGACAACGTCGAAGCGCTGCGCAACTGGCCCG
AGGTGTTCCGTGGCCGCACGATCTGGCTGCGCATCGACCTGGGGCACGGCGACGGCCATCACGAGAAGGTCAACACCGGC
GGCAAGGCGTCCAAGTTCGGCCTGTCGTCCACGCGCGTGGATGAATTCGTCGATGTGGCGCGCACGCTCGAGGTCACCAT
CACCGGCGTGCATGCGCATCTGGGCAGTGGCGTGGAGACCGGCGAGCACTGGCGGATGATGTACGACGAGTTGGCCGGCT
TCGCGCGTCGCATCGGCACGGTAGAGACCATCGACATCGGCGGCGGCCTGCCGATTCCGTACAGCGCCGAAGACGAGCCG
TTCGATCTGGAGGTGTGGGCCAAGGGCCTGGCCGAGGTCAAGGCGGTGCATCCTGGCTACCGCCTGGCGATCGAGCCGGG
CCGCTATCTGGTGGCCGAAGCCGGCGTCTTGCTGGCCAGCGTCACCCAGGTGATCGAGAAGGACGGTGTGCACCGCGTGG
GCCTGGATGCGGGCATGAACACCTTGATTCGCCCGGCGTTGTACGACGCCTGGCACGACATCGAAAACCTCAGCCAACTC
GACGCGCCGGCCGGCGGCATGTTCGATATCGTCGGGCCGATCTGCGAATCGTCGGACGTGTTCGGCAAGCGTCGCCGGCT
GCCAGCGGCCACTGCACCGGGCGATGTGGTGCTGGTCGCCGATGCCGGTGCCTACGGCTACACGATGGCCAGCACCTACA
ATCAGCGCGAATTGCCGCGCGAAGAGGTGATCGATGCGTCCACTGGCTGA

Upstream 100 bases:

>100_bases
TGTGATCGCACGCGGGGTCATGTCAGCAGCATTGGCAGTAGAATCGGAGGTTCCGCTCGGCATCCCGGGCATCTTCCCCC
CATCCTAAACGCATATCTCA

Downstream 100 bases:

>100_bases
GTTCGTCGTACTCAGCACGTTGGCCGGTGGCGTGGCGATGGTGTTTTCCACCGCCATCGATATCGCCGGGCAACCGACCC
CGTGGACCGACAGCTTGAAG

Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 869; Mature: 868

Protein sequence:

>869_residues
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLAGKRAHETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALDQRHR
EFLAELELDADAVLGERLAALHALLGDARAAMRTLDWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSAPPPQP
NQSEWSKRLSVSCQWQSDADWRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAEPVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
IGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQIAAVDQRYYAIKANAHPAILMALEQAGFGLECVS
HGELRRVFQTLPELSPRRVLFTPSFAPKAEYEAAFALGVTVTVDNVEALRNWPEVFRGRTIWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVDVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMNTLIRPALYDAWHDIENLSQL
DAPAGGMFDIVGPICESSDVFGKRRRLPAATAPGDVVLVADAGAYGYTMASTYNQRELPREEVIDASTG

Sequences:

>Translated_869_residues
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLAGKRAHETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALDQRHR
EFLAELELDADAVLGERLAALHALLGDARAAMRTLDWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSAPPPQP
NQSEWSKRLSVSCQWQSDADWRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAEPVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
IGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQIAAVDQRYYAIKANAHPAILMALEQAGFGLECVS
HGELRRVFQTLPELSPRRVLFTPSFAPKAEYEAAFALGVTVTVDNVEALRNWPEVFRGRTIWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVDVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMNTLIRPALYDAWHDIENLSQL
DAPAGGMFDIVGPICESSDVFGKRRRLPAATAPGDVVLVADAGAYGYTMASTYNQRELPREEVIDASTG
>Mature_868_residues
SAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLAGKRAHETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALDQRHRE
FLAELELDADAVLGERLAALHALLGDARAAMRTLDWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSAPPPQPN
QSEWSKRLSVSCQWQSDADWRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGMF
SANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAEPVLGVKAISRRNG
IVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAI
TLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQII
GSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQIAAVDQRYYAIKANAHPAILMALEQAGFGLECVSH
GELRRVFQTLPELSPRRVLFTPSFAPKAEYEAAFALGVTVTVDNVEALRNWPEVFRGRTIWLRIDLGHGDGHHEKVNTGG
KASKFGLSSTRVDEFVDVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEPF
DLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMNTLIRPALYDAWHDIENLSQLD
APAGGMFDIVGPICESSDVFGKRRRLPAATAPGDVVLVADAGAYGYTMASTYNQRELPREEVIDASTG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=391, Percent_Identity=33.5038363171356, Blast_Score=188, Evalue=2e-48,
Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=30.4157549234136, Blast_Score=175, Evalue=9e-45,
Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=30.188679245283, Blast_Score=173, Evalue=5e-44,
Organism=Escherichia coli, GI1790376, Length=328, Percent_Identity=32.9268292682927, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6320893, Length=503, Percent_Identity=27.037773359841, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322664, Length=360, Percent_Identity=23.0555555555556, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24586472, Length=347, Percent_Identity=27.0893371757925, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 94114; Mature: 93983

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLAGKRAHETGGRVLVVVSALSGVTNELTA
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHCCCCEEEEEEEHHCCHHHHHHH
IADGAADSAQRVAALDQRHREFLAELELDADAVLGERLAALHALLGDARAAMRTLDWQAE
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSAPPPQPNQSEWSKRLSVSCQWQSDAD
HHCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHCEEEEEECCCCC
WRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHHHHCCCCCEEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGNAEPVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
IGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQIAAVDQRYYAIKAN
HHCCCCCCCCCCCCCHHHHEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECC
AHPAILMALEQAGFGLECVSHGELRRVFQTLPELSPRRVLFTPSFAPKAEYEAAFALGVT
CCCEEEEEEHHCCCCCEECCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEE
VTVDNVEALRNWPEVFRGRTIWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVDVA
EEECCHHHHHCCHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCHH
TLIRPALYDAWHDIENLSQLDAPAGGMFDIVGPICESSDVFGKRRRLPAATAPGDVVLVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEE
DAGAYGYTMASTYNQRELPREEVIDASTG
CCCCCCEEECCCCCHHCCCHHHHCCCCCC
>Mature Secondary Structure 
SAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLAGKRAHETGGRVLVVVSALSGVTNELTA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHCCCCEEEEEEEHHCCHHHHHHH
IADGAADSAQRVAALDQRHREFLAELELDADAVLGERLAALHALLGDARAAMRTLDWQAE
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSAPPPQPNQSEWSKRLSVSCQWQSDAD
HHCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHCEEEEEECCCCC
WRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHHHHCCCCCEEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGNAEPVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
IGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQIAAVDQRYYAIKAN
HHCCCCCCCCCCCCCHHHHEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECC
AHPAILMALEQAGFGLECVSHGELRRVFQTLPELSPRRVLFTPSFAPKAEYEAAFALGVT
CCCEEEEEEHHCCCCCEECCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEE
VTVDNVEALRNWPEVFRGRTIWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVDVA
EEECCHHHHHCCHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCHH
TLIRPALYDAWHDIENLSQLDAPAGGMFDIVGPICESSDVFGKRRRLPAATAPGDVVLVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEE
DAGAYGYTMASTYNQRELPREEVIDASTG
CCCCCCEEECCCCCHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]