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The map label for this gene is gor [H]

Identifier: 78048459

GI number: 78048459

Start: 3305014

End: 3306384

Strand: Reverse

Name: gor [H]

Synonym: XCV2903

Alternate gene names: 78048459

Gene position: 3306384-3305014 (Counterclockwise)

Preceding gene: 78048460

Following gene: 78048458

Centisome position: 63.85

GC content: 64.11

Gene sequence:

>1371_bases
ATGAGTGCGCGTTACGACTACGACGTGGTGATTCTGGGGGGCGGCTCCGGCGGCCTCGCGGCTGGATTTCGCGCAGCAAA
ACATGGCGCGCGCGTGGCGATCATGGAGCCCGACGAACTGGGCGGCACCTGCGTCAATCTCGGTTGCGTGCCGAAGAAGG
CGATGTGGCTGGCAGCCGATCTGGCCGGCAAGATCGAGTTGGCCAGCGTGCTGGGATTCGATGTGCCGCGCCCGACGCTG
GCCTGGCAGGAGCTGGTCACGCATCGGCAGGGGTACATTTCCAACATCCACGCCAGCTATCGACGCCGCCTCAACGAAGA
TGGCGTGGTCCTGATCCCGCAACGCGGCGTATTGCAGGACCGCCATACCGTCATGGGCAGCGACGGCGTACCGGTGACCG
CCGAGCACATCGTGATCGCCACCGGCGCACACCCGCTACGCCCGGACGTGGAGGGCGCAGAACATGGCGAAGTCTCCGAC
GATTTCTTCAATCTCTGCCATGCGCCCGAGCAGGTCGCGATTGTCGGCGGTGGCTATATCGCGGTGGAAATCGCCGGGCT
GCTGCAGGCCCTGGGAAGTCGCGTGCATCTGTTCGTGCAGGACGAGCGCTTGCTGGAGCGCTTCGATGCGGAGCTCACCT
TGCAGTTGGCCGACAACCTGCGCCATCTGGGTGTGCGGCTGCACTTCGGTTTCACCACCACCGCATTGGAGCGCGATCTG
CACGGTGCGTTGCGCGTGCATGGTCATTGCGTGCATCCGCGCGAGCAGGGCAACGACGTCTTCGACAAGGTGTTTTTTGC
GGTGGGTCGCCGCGCCAATACCGCCGGGCTGGGTCTGGACACAGTGGGCGTTGCGCTTGGTGACAAGGGCGAAGTGGTGG
TGGACGACGGGCAGACCACCAACGTGCCGAATATTCACGCCATCGGCGATGTGGGCGGCAAGGTCGGACTGACGCCGGTG
GCGATTGCGGCAGGGCGCAAGCTGATGGATCGCCTGTTCGGTCACCAACCGGATGCGCGCATGGACTACGAAAACGTGCC
CAGCGTGGTGTTTTCGCACCCGCCGCTTGGCAATGTCGGGCTCACCGAAGAACAGGCGCGTGCACGGTACAACGGTGCGG
TGCGCGTGTACCGCAGCAATTTCCGCCCGATGCTGCACGCGCTGGCCGACGCGCCGCAGCGCAGTCTGTTCAAGCTGGTG
TGCGTGGGCGAGGAGGAACGTGTGGTCGGTGTCCATCTGCTGGGTGAGAGCGCCGACGAAATGCTGCAAGGCTTTGCGGT
GGCGGTGAAGATGGGCGCGACCAAGCGGGACTTCGAGGAGACCGTGGCGATTCATCCCACTTCGTCTGAAGAGATTGTGT
TGATGCATTGA

Upstream 100 bases:

>100_bases
GCATCAGCATGAGCACTGCAAGCGGACAATTGATGGCCGACCTGATCACGGGCCGCGCACCCGCGCTGGACCCGCATCCT
TACCGGGCGGAGCGTTTCGC

Downstream 100 bases:

>100_bases
GGGGGGCGCTGTCGCCATCGACGGTGGGTTGCCGCGTGGCGGCGCATGAGGCGATGCCTTGATCAATGCCAGACTGGGAT
AGCCAGTGGCAGCCGTAGCC

Product: putative glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAADLAGKIELASVLGFDVPRPTL
AWQELVTHRQGYISNIHASYRRRLNEDGVVLIPQRGVLQDRHTVMGSDGVPVTAEHIVIATGAHPLRPDVEGAEHGEVSD
DFFNLCHAPEQVAIVGGGYIAVEIAGLLQALGSRVHLFVQDERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDL
HGALRVHGHCVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDGQTTNVPNIHAIGDVGGKVGLTPV
AIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVGLTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLV
CVGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFEETVAIHPTSSEEIVLMH

Sequences:

>Translated_456_residues
MSARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAADLAGKIELASVLGFDVPRPTL
AWQELVTHRQGYISNIHASYRRRLNEDGVVLIPQRGVLQDRHTVMGSDGVPVTAEHIVIATGAHPLRPDVEGAEHGEVSD
DFFNLCHAPEQVAIVGGGYIAVEIAGLLQALGSRVHLFVQDERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDL
HGALRVHGHCVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDGQTTNVPNIHAIGDVGGKVGLTPV
AIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVGLTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLV
CVGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFEETVAIHPTSSEEIVLMH
>Mature_455_residues
SARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAADLAGKIELASVLGFDVPRPTLA
WQELVTHRQGYISNIHASYRRRLNEDGVVLIPQRGVLQDRHTVMGSDGVPVTAEHIVIATGAHPLRPDVEGAEHGEVSDD
FFNLCHAPEQVAIVGGGYIAVEIAGLLQALGSRVHLFVQDERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDLH
GALRVHGHCVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDGQTTNVPNIHAIGDVGGKVGLTPVA
IAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVGLTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLVC
VGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFEETVAIHPTSSEEIVLMH

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=44.1304347826087, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=38.135593220339, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=35.9408033826639, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=35.9408033826639, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=35.9408033826639, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=35.9408033826639, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=35.9408033826639, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=34.7547974413646, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=31.8376068376068, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=27.5488069414317, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=45.9770114942529, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=26.7818574514039, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=27.114967462039, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=27.765726681128, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=461, Percent_Identity=42.5162689804772, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI71983419, Length=461, Percent_Identity=42.5162689804772, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=32.0754716981132, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=32.3590814196242, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32565766, Length=470, Percent_Identity=28.0851063829787, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=40.5063291139241, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=27.2340425531915, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=25.3763440860215, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=36.3829787234043, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=36.3829787234043, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=36.1522198731501, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=35.5179704016913, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=27.3118279569892, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49189; Mature: 49058

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAAD
CCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHCCCEEEEECCCCCHHHEEEHH
LAGKIELASVLGFDVPRPTLAWQELVTHRQGYISNIHASYRRRLNEDGVVLIPQRGVLQD
HCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
RHTVMGSDGVPVTAEHIVIATGAHPLRPDVEGAEHGEVSDDFFNLCHAPEQVAIVGGGYI
CCEEECCCCCCEEECEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEE
AVEIAGLLQALGSRVHLFVQDERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDL
EEHHHHHHHHCCCEEEEEEECHHHHHHHCCCEEEHHHHCHHEEEEEEEECCCHHHHHHHH
HGALRVHGHCVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDGQTT
CCCEEECCEEECCHHCCCHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCCEEEECCCCC
NVPNIHAIGDVGGKVGLTPVAIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCCCCCCC
LTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLVCVGEEERVVGVHLLGESADE
CCHHHHHHHHCCEEEEEECCCHHHHHHHHCCCHHCEEEEEEECCCCCEEEEEEECCCHHH
MLQGFAVAVKMGATKRDFEETVAIHPTSSEEIVLMH
HHHHHHEEEECCCCCCCHHHEEEECCCCCCCEEEEC
>Mature Secondary Structure 
SARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAAD
CCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHCCCEEEEECCCCCHHHEEEHH
LAGKIELASVLGFDVPRPTLAWQELVTHRQGYISNIHASYRRRLNEDGVVLIPQRGVLQD
HCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
RHTVMGSDGVPVTAEHIVIATGAHPLRPDVEGAEHGEVSDDFFNLCHAPEQVAIVGGGYI
CCEEECCCCCCEEECEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEE
AVEIAGLLQALGSRVHLFVQDERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDL
EEHHHHHHHHCCCEEEEEEECHHHHHHHCCCEEEHHHHCHHEEEEEEEECCCHHHHHHHH
HGALRVHGHCVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDGQTT
CCCEEECCEEECCHHCCCHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCCEEEECCCCC
NVPNIHAIGDVGGKVGLTPVAIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCCCCCCC
LTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLVCVGEEERVVGVHLLGESADE
CCHHHHHHHHCCEEEEEECCCHHHHHHHHCCCHHCEEEEEEECCCCCEEEEEEECCCHHH
MLQGFAVAVKMGATKRDFEETVAIHPTSSEEIVLMH
HHHHHHEEEECCCCCCCHHHEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]