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The map label for this gene is mutL [H]

Identifier: 78048158

GI number: 78048158

Start: 2931887

End: 2933764

Strand: Reverse

Name: mutL [H]

Synonym: XCV2602

Alternate gene names: 78048158

Gene position: 2933764-2931887 (Counterclockwise)

Preceding gene: 78048159

Following gene: 78048157

Centisome position: 56.65

GC content: 66.93

Gene sequence:

>1878_bases
ATGGCGATCCGCCAGCTGCCCGAGATTCTGATCAACCAGATCGCTGCCGGCGAAGTCGTCGAGCGGCCCGCATCGGTGGT
CAAGGAACTGGTCGAAAACGCACTCGACGCCGGCGCCACGCGCGTGGATATCGAGCTCGAGGAGGGCGGCGTCCGGCTGA
TCCGCATCCGCGACAACGGTGGCGGCATCGCCCCGGACGAACTGCCGCTGGCCGTGTCGCGGCATGCCACCAGCAAGATC
GCTTCGCTGGACGACCTGGAAACCGTCGCCACGCTGGGCTTCCGTGGCGAAGCCTTGCCGTCGATCGCCTCGGTCAGCCG
CTTTACCCTGACCTCGCGTCGCCACGACGCCGAGCACGGCTCCGCATTGGAAATCGACGGCGGTCGCCTGGGCGAGGTGG
TGCCGCGCGCGCATGCGCCGGGCACCACGGTCGAAGTGCGCGAACTGTTCTTCAACGTGCCGGCGCGGCGCAAATTCCTG
CGTGCCGAACGCACCGAACTCGGCCACATCGAAGAGTGGTTGCGTTCGTTGGCATTGGCGCGGCCGGATGTGGAATTGCG
CGTCTCGCACAACGGCAAGCCGTCGCGTCGCTACAAGCCGGGCGATCTGTATTCGGACGCGCGGCTGGGCGAAACCCTCG
GCGACGATTTTGCGCGCCAGGCCTTGCGCGTGGACCACAGCGGCGCCGGTCTGCGCCTGCACGGCTGGGTTGCGCAACCG
CATTACTCGCGTGCCAGCACCGACCAGCAGTACCTCTACGTCAACGGACGTTCGGTCAGGGACCGCAGCGTGGCGCATGC
GGTGAAGATGGCCTACGGCGATGTGCTGTTTCATGGCCGTCAGCCGGCCTATGTGCTGTTTCTGGAGCTGGACCCGGCAC
GCGTGGACGTCAATGTGCACCCGGCCAAACACGAGGTGCGTTTCCGCGAAGCGCGGCTGATCCACGATTTCGTCTATCGC
ACCCTGCAGGATGCCTTGGCGCATACCCGTGCCGGCGTCACGCCAAACAGTATCGGCAGCGATGGTGCCGGCGACCCAGG
TGCGACCGCTGGCGGACTGGGCAACATTGCTGGCAGCGGTGTTCCTAACCACGGCAACGCAGCTGGCAGCAGCGGTAGCG
GCTACAACTACGCGAGCTGGACGCCTTCGCAAACGCCGCTGGGATTGCGTGTGGACGAGGCGCGCGCCGCCTACAGCGCG
CTGTACGCGCCGCCGCCCAGCAGTGCGCAGCAATCGGCAGGCATGCCGAGCATGGCCGGCACCGGGTTGCCGGCAACTGC
GCAAGACAGCGGTGTTCCGCCGCTCGGTTATGCCGTCGCGCAGTTGCACGGCATCTACATCCTGGCCGAAAACGCCGAAG
GCTTGATCGTGGTCGACATGCACGCGGCGCATGAGCGCATCGGCTATGAGCGGCTCAAAAATGCGCACGACAGCATCGGC
CTGCACGCGCAGCCCTTGCTGGTGCCGATGACGCTGGCAGTGGGCGAGCGCGAAGCCGACACCGCCGAGCGCGAAGCGGA
GACCTTGGCCACGCTCGGCTTCGAGATCACCCGGGCCGGCCCGCAGTCGCTGCACGTGCGCAGCATTCCCGCGCTGCTGG
CCAATGCCGAGCCGGAGGCGCTGCTGCGCGATGTGCTGGGCGATCTGCGCGAGCATGGTCAAAGCCGCCGCATCGCCAGC
GCACGCGACGAACTGCTCTCCACCATGGCGTGCCACGGTGCAGTGCGCGCCAACCGCCGCCTCACCGTGCCTGAAATGAA
CGCGCTGCTGCGCGATATGGAAGCCACCGAACGCTCGGGCCAGTGCAACCATGGCCGACCGACCTGGGCGCGGTTTACGC
TGAGCGATATCGATCGTTGGTTTCTGAGGGGGCGTTGA

Upstream 100 bases:

>100_bases
CGGCGACTGTGCGCCGCCGGATTGCCGTGCCGAGTTCTGTCTTGCCTGTCACACCGCCGATCTACCGCGTTTCGCGCGTG
CTGCAATGGAGCGTGCGCTG

Downstream 100 bases:

>100_bases
TGGCAGTGCACGGGGGGAAGGGCTGGCTGCTCGGCATGCTGGTCGCAGCGGCGTTATTCGGTTGCGGGCGCGATGCGCCA
CCGCCGGCTGCGCCGGTCGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGIAPDELPLAVSRHATSKI
ASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFL
RAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYR
TLQDALAHTRAGVTPNSIGSDGAGDPGATAGGLGNIAGSGVPNHGNAAGSSGSGYNYASWTPSQTPLGLRVDEARAAYSA
LYAPPPSSAQQSAGMPSMAGTGLPATAQDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKNAHDSIG
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLGDLREHGQSRRIAS
ARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR

Sequences:

>Translated_625_residues
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGIAPDELPLAVSRHATSKI
ASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFL
RAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYR
TLQDALAHTRAGVTPNSIGSDGAGDPGATAGGLGNIAGSGVPNHGNAAGSSGSGYNYASWTPSQTPLGLRVDEARAAYSA
LYAPPPSSAQQSAGMPSMAGTGLPATAQDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKNAHDSIG
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLGDLREHGQSRRIAS
ARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR
>Mature_624_residues
AIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGIAPDELPLAVSRHATSKIA
SLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLR
AERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQPH
YSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYRT
LQDALAHTRAGVTPNSIGSDGAGDPGATAGGLGNIAGSGVPNHGNAAGSSGSGYNYASWTPSQTPLGLRVDEARAAYSAL
YAPPPSSAQQSAGMPSMAGTGLPATAQDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKNAHDSIGL
HAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLGDLREHGQSRRIASA
RDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=33.6363636363636, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=29.2397660818713, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=29.2397660818713, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=30.3951367781155, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=30.3951367781155, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI189458896, Length=322, Percent_Identity=31.3664596273292, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=26.510067114094, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI91992160, Length=330, Percent_Identity=26.3636363636364, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI91992162, Length=330, Percent_Identity=26.3636363636364, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1790612, Length=560, Percent_Identity=42.6785714285714, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=34.5911949685535, Blast_Score=183, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=341, Percent_Identity=28.7390029325513, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=315, Percent_Identity=33.6507936507937, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=28.808864265928, Blast_Score=133, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=722, Percent_Identity=20.6371191135734, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=372, Percent_Identity=23.9247311827957, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136968, Length=312, Percent_Identity=34.9358974358974, Blast_Score=187, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17136970, Length=397, Percent_Identity=27.455919395466, Blast_Score=129, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67607; Mature: 67476

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECCC
GGIAPDELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALA
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVH
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEC
PAKHEVRFREARLIHDFVYRTLQDALAHTRAGVTPNSIGSDGAGDPGATAGGLGNIAGSG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VPNHGNAAGSSGSGYNYASWTPSQTPLGLRVDEARAAYSALYAPPPSSAQQSAGMPSMAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
TGLPATAQDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKNAHDSIG
CCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHCHHHCCC
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEA
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHCCCCHHH
LLRDVLGDLREHGQSRRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
QCNHGRPTWARFTLSDIDRWFLRGR
CCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
AIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECCC
GGIAPDELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALA
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
HYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVH
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEC
PAKHEVRFREARLIHDFVYRTLQDALAHTRAGVTPNSIGSDGAGDPGATAGGLGNIAGSG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VPNHGNAAGSSGSGYNYASWTPSQTPLGLRVDEARAAYSALYAPPPSSAQQSAGMPSMAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
TGLPATAQDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKNAHDSIG
CCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHCHHHCCC
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEA
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHCCCCHHH
LLRDVLGDLREHGQSRRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
QCNHGRPTWARFTLSDIDRWFLRGR
CCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]