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The map label for this gene is apt [H]

Identifier: 78048144

GI number: 78048144

Start: 2917002

End: 2917562

Strand: Reverse

Name: apt [H]

Synonym: XCV2588

Alternate gene names: 78048144

Gene position: 2917562-2917002 (Counterclockwise)

Preceding gene: 78048145

Following gene: 78048142

Centisome position: 56.34

GC content: 65.42

Gene sequence:

>561_bases
ATGACTGACTGCAGCCGCTGCGCCGGCACCACGACTTCCGGACCCAACCATTGGTCGGAGCGGATTCGCGACATCGCCGA
TTTCCCCAAGCAGGGCATCGTCTTCAAGGACATTACCCCGTTGCTGTCGGACGGCCCGGATTTCGCCTCTGCGCTGGACG
AAATGGCGCAGCCGTGGCGCACCACGCCGCTGGATGCGGTGCTGGGTATCGAGGCGCGCGGTTTCATTCTGGGCGCTGCC
CTGGCGCGCGAACTGCGGACCGGCTTCGTGCCGGTGCGCAAGCCGGGCAAGCTGCCGGGGCGCACGCTGATCCAGGAATA
CGCGCTGGAGTACGGCACCGATCGCATCGAAATGCATGAGGATGCGCTGCCACGCGGGGCGCGCGTACTGATTGTCGACG
ACGTGCTGGCCACCGGCGGCACGCTGCGTGCGGCCCTGGGACTTGCTGCCCAACTCGAACTGGAAGTCGTTGGCGCAGCC
GTGCTGGTGGAATTGCAGGTGCTGCAGGGTCGCCAGAAATGGGCGAACGATGTGCCGCTGTTGGCGACACTTTCTTACTG
A

Upstream 100 bases:

>100_bases
TCCTGACGCGCTCAGATGCAGGTATGCCGTAAATCCGGCGTGGATGGCGTGCGCAGCCTAGAATAGGCGCAACCCCACCG
GCCACCACGCCACCGCCCTC

Downstream 100 bases:

>100_bases
GTCCAAGCGCTGAAGCGACCCTGGATGCGTGGACGTGCGCGCATCCAGGATTGCTCCTGCTGAAACATGGGCGGCCGGCA
CGACGCCGGCCGCGCTGCGT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTDCSRCAGTTTSGPNHWSERIRDIADFPKQGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAA
VLVELQVLQGRQKWANDVPLLATLSY

Sequences:

>Translated_186_residues
MTDCSRCAGTTTSGPNHWSERIRDIADFPKQGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAA
VLVELQVLQGRQKWANDVPLLATLSY
>Mature_185_residues
TDCSRCAGTTTSGPNHWSERIRDIADFPKQGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAAL
ARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAAV
LVELQVLQGRQKWANDVPLLATLSY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=46.4705882352941, Blast_Score=144, Evalue=3e-35,
Organism=Homo sapiens, GI71773201, Length=123, Percent_Identity=47.1544715447154, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=46.2025316455696, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=46.1988304093567, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=38.6503067484663, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=167, Percent_Identity=32.9341317365269, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=165, Percent_Identity=36.969696969697, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20120; Mature: 19989

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDCSRCAGTTTSGPNHWSERIRDIADFPKQGIVFKDITPLLSDGPDFASALDEMAQPWR
CCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHCCHHHCCCCHHHHHHHHHHCCCC
TTPLDAVLGIEARGFILGAALARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHE
CCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECH
DALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAAVLVELQVLQGRQKWANDVPL
HCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCE
LATLSY
EEEECC
>Mature Secondary Structure 
TDCSRCAGTTTSGPNHWSERIRDIADFPKQGIVFKDITPLLSDGPDFASALDEMAQPWR
CCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHCCHHHCCCCHHHHHHHHHHCCCC
TTPLDAVLGIEARGFILGAALARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHE
CCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECH
DALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAAVLVELQVLQGRQKWANDVPL
HCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCE
LATLSY
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]