Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 78048100

GI number: 78048100

Start: 2871465

End: 2872763

Strand: Reverse

Name: argH [H]

Synonym: XCV2544

Alternate gene names: 78048100

Gene position: 2872763-2871465 (Counterclockwise)

Preceding gene: 78048101

Following gene: 78048099

Centisome position: 55.48

GC content: 65.97

Gene sequence:

>1299_bases
ATGACCAATCTGTTGTGGCAAAAACCTGGCGTTGCCGTTGACGCCAAGATCCAGAGTTTCCTGGCCGGCGACGATGTGAT
CCTGGATCGCGAATTCTTCCTGTACGACATCGCTGCCAGCAAGGCGCATGCGCAGGGGCTGCAGCACATCGGCATCTTGT
CGTTGCAGGAGCTGGGCGGCTTGAGCGAACAGCTCGACCTGCTGGCCGCCGATTTTCGCAGCGGCGCCTTCGTGCTCGAT
GCGCAATACGAAGATTGCCACTCCGCCATCGAAGCGCGATTGACCGAGCGTCTGGGCGATGCAGGCCGCAAGATCCACAC
CGGGCGTAGCCGCAACGACCAAATCCTGGTCGCCACGCGGCTGTGGCTGAAGGACAAGCTGCAGCGCGTTGCCACGCTCA
GCGCGGAGATCGCCAAGGTGGCGTTGGACCGCGCACAGGCCGAGGCTGGGCTGCCGGTGCCCGGTTATACGCACATCCAA
CGGGCGGTGGTGTCCTCGGCCGGGATGTGGTGGGCGGGCTGGGCGGAAGCGTTCATCGACAACGCCGTGCGCGCCGACGA
CACCGTCCGTTTGGTCGACAGCAACCCGCTTGGCACCGCTGCAGGCTATGGCGTGAATCTGCCGCTGGATCGTGCGCATA
CCACCGCCGAACTGGGGTTTGCACGCCTGTTGGTCTCGCCGATCTACGCCCAGCTTTCGCGCGGCAAGTACGAACTGGCC
GCGCTCGAAGCGCTCGGCAGCGCCACGCTGGATCTGCGCCGCATCGCCTGGGATCTGTCGCTGTTCACCAGTGGCGAATT
CGCGTTTGTCGCCTTGCCGGCCCAATACACCACCGGCAGTTCGATCATGCCGAACAAGCGCAACCCGGACGTGATCGAGC
TGATGCGCGCAACGCATGCCAGCGTGGCGGCAGCGCGCACCGAGATCGAACAGCTGCTGTCGCTGCCGTCGGGTTATCAC
CGCGATCTGCAGAGCAGCAAGGGCGCGATCGTGCACGGCTTTGGCCGCGGACTTGCGGCGCTGGAACTGCTGCCGGCCTT
GCTGGCCAATCTGGAATGGCGCCCGGACAAACTGCGCGCAGCCATCGATTCGGGCATGTATGCCACCGATGTGGCAGTGG
AAGCCGCGGTAGCCGGCGTGCCGTTCCGCGAGGCCTACAAGGCCGCAGCGCAGGCCGCCGAGACCGCAGGGCAGGGACGC
ACGCCGGAAGGCAGCCTGGCTGCGCGCGTGTCGCCCGGTGCGGCAGCCGACCTGCAACTGGATGTGCTGCAGGCGCGCTG
GCAGGCGCTGCGCGCATGA

Upstream 100 bases:

>100_bases
ACATCCATGTGCGGGGATTTAACGAAGCGAGTCCCTCGCAACAGCCCGCGCATCCATGTGCGGGGATCGAAACTGGACGA
CTTACTCGAGACGCTTTCCG

Downstream 100 bases:

>100_bases
CGACCCGCTATCTGGTGCTTGCGCTGCGCAAGCCGGGGTTTCCCGCCGATGTGGTGCAGCCGCATCTGGACTTTCTCGAT
GCATTGCGCGCCGCCGGGCA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQLDLLAADFRSGAFVLD
AQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAKVALDRAQAEAGLPVPGYTHIQ
RAVVSSAGMWWAGWAEAFIDNAVRADDTVRLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLVSPIYAQLSRGKYELA
ALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYH
RDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREAYKAAAQAAETAGQGR
TPEGSLAARVSPGAAADLQLDVLQARWQALRA

Sequences:

>Translated_432_residues
MTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQLDLLAADFRSGAFVLD
AQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAKVALDRAQAEAGLPVPGYTHIQ
RAVVSSAGMWWAGWAEAFIDNAVRADDTVRLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLVSPIYAQLSRGKYELA
ALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYH
RDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREAYKAAAQAAETAGQGR
TPEGSLAARVSPGAAADLQLDVLQARWQALRA
>Mature_431_residues
TNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQLDLLAADFRSGAFVLDA
QYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAKVALDRAQAEAGLPVPGYTHIQR
AVVSSAGMWWAGWAEAFIDNAVRADDTVRLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLVSPIYAQLSRGKYELAA
LEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYHR
DLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREAYKAAAQAAETAGQGRT
PEGSLAARVSPGAAADLQLDVLQARWQALRA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=393, Percent_Identity=35.1145038167939, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI68303542, Length=393, Percent_Identity=35.1145038167939, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI68303549, Length=393, Percent_Identity=34.3511450381679, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI68303547, Length=392, Percent_Identity=33.6734693877551, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1790398, Length=396, Percent_Identity=32.0707070707071, Blast_Score=195, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321806, Length=372, Percent_Identity=30.3763440860215, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI221473854, Length=396, Percent_Identity=31.5656565656566, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI78706858, Length=396, Percent_Identity=31.5656565656566, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 46367; Mature: 46236

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGG
CCCCCCCCCCCEEHHHHHHHHCCCCEEECCHHEEEEHHHHHHHHHHHHHHHHEEHHHHCC
LSEQLDLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATR
CHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEHH
LWLKDKLQRVATLSAEIAKVALDRAQAEAGLPVPGYTHIQRAVVSSAGMWWAGWAEAFID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
NAVRADDTVRLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLVSPIYAQLSRGKYELA
HCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHA
HHHHHCCHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
SVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRA
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHH
AIDSGMYATDVAVEAAVAGVPFREAYKAAAQAAETAGQGRTPEGSLAARVSPGAAADLQL
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHH
DVLQARWQALRA
HHHHHHHHHHCC
>Mature Secondary Structure 
TNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGG
CCCCCCCCCCEEHHHHHHHHCCCCEEECCHHEEEEHHHHHHHHHHHHHHHHEEHHHHCC
LSEQLDLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATR
CHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEHH
LWLKDKLQRVATLSAEIAKVALDRAQAEAGLPVPGYTHIQRAVVSSAGMWWAGWAEAFID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
NAVRADDTVRLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLVSPIYAQLSRGKYELA
HCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHA
HHHHHCCHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
SVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRA
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHH
AIDSGMYATDVAVEAAVAGVPFREAYKAAAQAAETAGQGRTPEGSLAARVSPGAAADLQL
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHH
DVLQARWQALRA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]