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The map label for this gene is alsR [H]

Identifier: 78047857

GI number: 78047857

Start: 2634988

End: 2635878

Strand: Reverse

Name: alsR [H]

Synonym: XCV2301

Alternate gene names: 78047857

Gene position: 2635878-2634988 (Counterclockwise)

Preceding gene: 78047858

Following gene: 78047855

Centisome position: 50.9

GC content: 58.59

Gene sequence:

>891_bases
ATGGAACTGCGACATCTTCGCTACTTTGTCGTCTTGGCTGACGAGCTGCATTTCACGCACGCCGCGGAGCGGCTGCATAT
CGAACAACCGCCCTTGTCTCGGGCGATCAAAGAGCTGGAAGACGAACTAGGGGTCGTACTCTTTGATCGTGATCGCAGAG
GAACGCGGCTGACCGCCGCAGGAGTTGCCTTCCTGCAAGACTCTCGCAGGCTTTTCACCGTTCTCGAACAAGCCCGGGAG
AACGTCAAGGCCGTCGCGGCGGGTTTGCGGGGTAGCCTGCGTATCGCGGTGTCTGATGGAGCAATCGACCCTAGGCTTTC
ATCGTTCCTGGCCCGTTGCCGCGCCGAAGAACCAGAGATCGAAATACGCCTGTCCGAAGTACCCTTGGCCGAACAGATGC
GGGGGCTTCGATCCGGCGATTTCATGATCGGCTTCGCACACACCGCGGATGTCAACGACGGTATCGTTGCCGAACCAATA
TGGCGAGACCCGCTGGTAATTGCCGTACCGGCACGGCACGCGCTACTCGCTCACAAGGAAGTGCCACTTCATGAACTTAG
CGGTCACCCGCTTGTCTTGTGCGATCCGCAAGTCTGCGAGGGTTACTGCCGCGAGCTGGCGCGCCTTCTAGGACCTCTGG
GACACCAGAAAAACGTCGTTGAGCATGTAACCTCTTTGGACATGATGCTCACGCTGGTCGGTGCCGGTTATGGTGTTGGC
TTCATGGCCGCGAACAGAACTCCAGCCACACAGCGGCCTGATGTCGTAATACGCCCGTTGGCTGTTGAATCCGCAATTAT
TACGACCTACGTGCTTCGGCCCGACAATAGCGCCTCTTCGGCCTCTCTGGAGCGGTTTATCGCGCGCCTGCGCGAAGGGC
TGGGTAACTAA

Upstream 100 bases:

>100_bases
AGGCCCAGCCGTGATCGAAATCGCGCGCATGCAGCGGACAGGATGGGTCTATATCAGATCATAGCAACAGGCCGCCCAGG
CGGCAGAAGGGGCTGGGGAC

Downstream 100 bases:

>100_bases
CCTGGCTCAAGATTCGACAGTGGAATCCATATTGCGCTCTGTGGCGGCCATTAGATCGGTCCCACTCATCTTCAGCGCAG
TGGCGATTTTCAGTATCAGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MELRHLRYFVVLADELHFTHAAERLHIEQPPLSRAIKELEDELGVVLFDRDRRGTRLTAAGVAFLQDSRRLFTVLEQARE
NVKAVAAGLRGSLRIAVSDGAIDPRLSSFLARCRAEEPEIEIRLSEVPLAEQMRGLRSGDFMIGFAHTADVNDGIVAEPI
WRDPLVIAVPARHALLAHKEVPLHELSGHPLVLCDPQVCEGYCRELARLLGPLGHQKNVVEHVTSLDMMLTLVGAGYGVG
FMAANRTPATQRPDVVIRPLAVESAIITTYVLRPDNSASSASLERFIARLREGLGN

Sequences:

>Translated_296_residues
MELRHLRYFVVLADELHFTHAAERLHIEQPPLSRAIKELEDELGVVLFDRDRRGTRLTAAGVAFLQDSRRLFTVLEQARE
NVKAVAAGLRGSLRIAVSDGAIDPRLSSFLARCRAEEPEIEIRLSEVPLAEQMRGLRSGDFMIGFAHTADVNDGIVAEPI
WRDPLVIAVPARHALLAHKEVPLHELSGHPLVLCDPQVCEGYCRELARLLGPLGHQKNVVEHVTSLDMMLTLVGAGYGVG
FMAANRTPATQRPDVVIRPLAVESAIITTYVLRPDNSASSASLERFIARLREGLGN
>Mature_296_residues
MELRHLRYFVVLADELHFTHAAERLHIEQPPLSRAIKELEDELGVVLFDRDRRGTRLTAAGVAFLQDSRRLFTVLEQARE
NVKAVAAGLRGSLRIAVSDGAIDPRLSSFLARCRAEEPEIEIRLSEVPLAEQMRGLRSGDFMIGFAHTADVNDGIVAEPI
WRDPLVIAVPARHALLAHKEVPLHELSGHPLVLCDPQVCEGYCRELARLLGPLGHQKNVVEHVTSLDMMLTLVGAGYGVG
FMAANRTPATQRPDVVIRPLAVESAIITTYVLRPDNSASSASLERFIARLREGLGN

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=32.0557491289199, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1788887, Length=268, Percent_Identity=35.0746268656716, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI2367136, Length=260, Percent_Identity=30.3846153846154, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI157672245, Length=295, Percent_Identity=30.5084745762712, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790399, Length=262, Percent_Identity=25.9541984732824, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693105, Length=290, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788748, Length=256, Percent_Identity=27.34375, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=28, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788297, Length=127, Percent_Identity=38.5826771653543, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787530, Length=261, Percent_Identity=25.2873563218391, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787601, Length=212, Percent_Identity=24.0566037735849, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=25.4237288135593, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87081904, Length=195, Percent_Identity=27.1794871794872, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789173, Length=127, Percent_Identity=37.007874015748, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32676; Mature: 32676

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFVVLADELHFTHAAERLHIEQPPLSRAIKELEDELGVVLFDRDRRGTRLTAA
CCCCCEEEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEHHH
GVAFLQDSRRLFTVLEQARENVKAVAAGLRGSLRIAVSDGAIDPRLSSFLARCRAEEPEI
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCE
EIRLSEVPLAEQMRGLRSGDFMIGFAHTADVNDGIVAEPIWRDPLVIAVPARHALLAHKE
EEEEECCCHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHCCC
VPLHELSGHPLVLCDPQVCEGYCRELARLLGPLGHQKNVVEHVTSLDMMLTLVGAGYGVG
CCHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
FMAANRTPATQRPDVVIRPLAVESAIITTYVLRPDNSASSASLERFIARLREGLGN
EEECCCCCCCCCCCEEEECHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELRHLRYFVVLADELHFTHAAERLHIEQPPLSRAIKELEDELGVVLFDRDRRGTRLTAA
CCCCCEEEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEHHH
GVAFLQDSRRLFTVLEQARENVKAVAAGLRGSLRIAVSDGAIDPRLSSFLARCRAEEPEI
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCE
EIRLSEVPLAEQMRGLRSGDFMIGFAHTADVNDGIVAEPIWRDPLVIAVPARHALLAHKE
EEEEECCCHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHCCC
VPLHELSGHPLVLCDPQVCEGYCRELARLLGPLGHQKNVVEHVTSLDMMLTLVGAGYGVG
CCHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
FMAANRTPATQRPDVVIRPLAVESAIITTYVLRPDNSASSASLERFIARLREGLGN
EEECCCCCCCCCCCEEEECHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]