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The map label for this gene is edd [H]

Identifier: 78047790

GI number: 78047790

Start: 2565633

End: 2567549

Strand: Reverse

Name: edd [H]

Synonym: XCV2234

Alternate gene names: 78047790

Gene position: 2567549-2565633 (Counterclockwise)

Preceding gene: 78047791

Following gene: 78047789

Centisome position: 49.58

GC content: 67.19

Gene sequence:

>1917_bases
ATGAGCCTGCATCCGAATATCCAAGCCGTCACCGACCGTATCCGCAAGCGCAGCGCTCCCTCGCGCGCAGCGTATCTGGC
CGGTCTCGATGCTGCCCTGCGTGAGGGTCCGTTCCGTAGCCGCTTGAGCTGCGGCAATCTTGCGCATGGCTTCGCTGCGT
CCGAGCCGGGCGACAAATCGCGCCTGCGTGGTGCGGCCACGCCGAACCTGGGCATCATCACTGCCTATAACGACATGTTG
TCGGCACATCAGCCGTTCGAACACTACCCGCAGCTGATCCGCGAGACTGCCCGCGCGCTCGGTGCCACCGCACAGGTGGC
CGGTGGCGTGCCGGCGATGTGCGACGGCGTCACCCAGGGCCGCGCCGGCATGGAGCTGTCGCTCTTTTCGCGCGACAACA
TCGCCCAGGCGACAGCCATCGGCCTGAGCCACGACATGTTCGACAGCGTGGTGTACCTGGGCGTCTGCGACAAGATCGTG
CCGGGCCTGCTGATCGGTGCGCTGGCGTTCGGCCATTTGCCGGCGATTTTCATGCCGGCCGGCCCGATGACGCCGGGCAT
TCCGAACAAGCAGAAGGCCGAAGTGCGCGAACGCTACGCCGCTGGCGAAGCCACGCGCGCCGAGCTGCTGGAAGCCGAGG
CCTCGTCCTACCACTCGCCGGGCACCTGCACCTTCTACGGCACGGCCAACTCCAACCAGGTCTTGCTCGAAGCGATGGGC
GTGCAGCTGCCCGGCGCCTCGTTCGTCAATCCGGAGCTGCCGTTGCGTGATGCGTTGACCCGCGAAGGCACCGCGCGCGC
ATTGGCGATCTCGGCGTTGGGCGAAGATTTCCGTCCATTCGGTCGCCTGATCGACGAGCGCGCCATCGTCAACGCCGTGG
TCGCGCTGATGGCGACCGGTGGCTCGACCAACCACACCATCCACTGGATCGCAGTGGCGCGTGCGGCCGGCATCGTGCTG
ACCTGGGACGACATGGACCTGATTTCGCAGACGGTGCCGCTGCTGACGCGCATCTACCCGAACGGCGAAGCCGACGTGAA
TCGCTTCCAGGCCGCTGGCGGCACGGCATTCGTGTTCCGCGAGCTGATGGACGCCGGCTACATGCACGACGACCTACCCA
CCGTGGTGGAAGGCGGCATGCGTGCCTACATCAATGAGCCGCGCCTGCAGGACGGCAAGGTGACCTACGTGCCAGGCACT
CCCACCACCGCCGACGACAGCGTGGCGCGTCCGGTCGGCGATGCCTTCGAATCGCAAGGCGGGCTGCGCCTGCTGCGCGG
CAATCTCGGTCGCTCGTTGATCAAGCTGTCGGCAGTCAAGCCGCAGCATCGCAGCATCCAGGCGCCGGCCGTGGTGATCG
ATACGCCGCAGGTGCTCAACAAACTGCATGCTGCCGGCGTGTTGCCGCACGATTTCGTGGTGGTGTTGCGCTACCAGGGC
CCGCGCGCAAACGGCATGCCGGAGCTGCATTCGATGGCGCCGCTGCTGGGCTTGCTGCAGAACCAGGGCCGGCGCGTGGC
ATTGGTCACCGACGGCCGCCTGTCCGGTGCCTCGGGCAAGTTCCCGGCCGCAATCCACCTGACGCCCGAAGCGGCACGCG
GCGGCCCGATCGGGCGCGTACGCGAAGGCGACATCGTGCGCCTGGACGGCGAAGCCGGCACCCTGGAAGTGCTGGTCTCG
GCCGAAGAATGGGCATCGCGCGAGGTTGCACCCAATACGTCCGTTGCCGGCAATGACCTGGGCCGCAATCTGTTCGCCAT
CAACCGCCAGGTCGTCGGCCCCGCCGACCAGGGCGCGATTTCGATTTCCTGCGGCCCGACCCATCCGGACGGTGCGCTGT
GGAGCTACGACGCCGAGTACGAACTCGGTGCCGATGCTGCCGCTGCGGCAGCACCCCACGAGTCCAAGGACGCCTGA

Upstream 100 bases:

>100_bases
CAGCCGATGCGATGCGAGTCCCTCGCAAAAACCCGCACATCCATGTGCGGGGAATTAAAAGAGCATTTTCTGCCCCCCTG
TTTCTCATAGCCGGTAGCCA

Downstream 100 bases:

>100_bases
TCCCCTTCCCTCTGTGCGGCCGCTCCGGCGGTCGCCGTCACCCGGAGTTGCAATGACGATTGCCCAGACCCAGAACACCG
CCGAACGTTTGCTGCGCGAT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEPGDKSRLRGAATPNLGIITAYNDML
SAHQPFEHYPQLIRETARALGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQATAIGLSHDMFDSVVYLGVCDKIV
PGLLIGALAFGHLPAIFMPAGPMTPGIPNKQKAEVRERYAAGEATRAELLEAEASSYHSPGTCTFYGTANSNQVLLEAMG
VQLPGASFVNPELPLRDALTREGTARALAISALGEDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVL
TWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLPTVVEGGMRAYINEPRLQDGKVTYVPGT
PTTADDSVARPVGDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRSIQAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRVREGDIVRLDGEAGTLEVLVS
AEEWASREVAPNTSVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA

Sequences:

>Translated_638_residues
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEPGDKSRLRGAATPNLGIITAYNDML
SAHQPFEHYPQLIRETARALGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQATAIGLSHDMFDSVVYLGVCDKIV
PGLLIGALAFGHLPAIFMPAGPMTPGIPNKQKAEVRERYAAGEATRAELLEAEASSYHSPGTCTFYGTANSNQVLLEAMG
VQLPGASFVNPELPLRDALTREGTARALAISALGEDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVL
TWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLPTVVEGGMRAYINEPRLQDGKVTYVPGT
PTTADDSVARPVGDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRSIQAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRVREGDIVRLDGEAGTLEVLVS
AEEWASREVAPNTSVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
>Mature_637_residues
SLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEPGDKSRLRGAATPNLGIITAYNDMLS
AHQPFEHYPQLIRETARALGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQATAIGLSHDMFDSVVYLGVCDKIVP
GLLIGALAFGHLPAIFMPAGPMTPGIPNKQKAEVRERYAAGEATRAELLEAEASSYHSPGTCTFYGTANSNQVLLEAMGV
QLPGASFVNPELPLRDALTREGTARALAISALGEDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVLT
WDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLPTVVEGGMRAYINEPRLQDGKVTYVPGTP
TTADDSVARPVGDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRSIQAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQGP
RANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRVREGDIVRLDGEAGTLEVLVSA
EEWASREVAPNTSVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=52.8239202657807, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=547, Percent_Identity=27.9707495429616, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI2367371, Length=459, Percent_Identity=30.5010893246187, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786464, Length=460, Percent_Identity=28.9130434782609, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322476, Length=483, Percent_Identity=29.8136645962733, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 67410; Mature: 67279

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEPGDKS
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCHH
RLRGAATPNLGIITAYNDMLSAHQPFEHYPQLIRETARALGATAQVAGGVPAMCDGVTQG
HCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCC
RAGMELSLFSRDNIAQATAIGLSHDMFDSVVYLGVCDKIVPGLLIGALAFGHLPAIFMPA
CCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
GPMTPGIPNKQKAEVRERYAAGEATRAELLEAEASSYHSPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECC
VQLPGASFVNPELPLRDALTREGTARALAISALGEDFRPFGRLIDERAIVNAVVALMATG
CCCCCCCCCCCCCCHHHHHCCCCCHHEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGIVLTWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHH
ELMDAGYMHDDLPTVVEGGMRAYINEPRLQDGKVTYVPGTPTTADDSVARPVGDAFESQG
HHHHCCCCCCCCHHHHHCCHHEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
GLRLLRGNLGRSLIKLSAVKPQHRSIQAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
CEEEEHHHHCHHHHHHHCCCCHHCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRV
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
REGDIVRLDGEAGTLEVLVSAEEWASREVAPNTSVAGNDLGRNLFAINRQVVGPADQGAI
CCCCEEEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCHHCCCEEEECCEEECCCCCCEE
SISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
EEEECCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASEPGDKS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCHH
RLRGAATPNLGIITAYNDMLSAHQPFEHYPQLIRETARALGATAQVAGGVPAMCDGVTQG
HCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCC
RAGMELSLFSRDNIAQATAIGLSHDMFDSVVYLGVCDKIVPGLLIGALAFGHLPAIFMPA
CCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
GPMTPGIPNKQKAEVRERYAAGEATRAELLEAEASSYHSPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECC
VQLPGASFVNPELPLRDALTREGTARALAISALGEDFRPFGRLIDERAIVNAVVALMATG
CCCCCCCCCCCCCCHHHHHCCCCCHHEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGIVLTWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHH
ELMDAGYMHDDLPTVVEGGMRAYINEPRLQDGKVTYVPGTPTTADDSVARPVGDAFESQG
HHHHCCCCCCCCHHHHHCCHHEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
GLRLLRGNLGRSLIKLSAVKPQHRSIQAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
CEEEEHHHHCHHHHHHHCCCCHHCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRV
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
REGDIVRLDGEAGTLEVLVSAEEWASREVAPNTSVAGNDLGRNLFAINRQVVGPADQGAI
CCCCEEEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCHHCCCEEEECCEEECCCCCCEE
SISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
EEEECCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]