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The map label for this gene is mntH [H]

Identifier: 78047753

GI number: 78047753

Start: 2526833

End: 2528167

Strand: Reverse

Name: mntH [H]

Synonym: XCV2197

Alternate gene names: 78047753

Gene position: 2528167-2526833 (Counterclockwise)

Preceding gene: 78047757

Following gene: 78047752

Centisome position: 48.82

GC content: 65.02

Gene sequence:

>1335_bases
ATGTCCGCCAACACCGCCGCCTCAGCGCCATCGCCAGCCACCGCCACCGGCGGCCTGGGCGACCACCAGGCCAGCGTCTC
CGTGCCCAAGGGCGGCCATTGGTGGTTCCGCCTGCTGGCCTTCCTGGGACCGGGCTACATGGTGTCGGTGGGCTATATGG
ACCCGGGCAACTGGGCCACCGATCTGGCCGGCGGGTCGCAGTTCGGCTACCTGCTGCTGTCGGTGATCCTGTTGTCGAAC
CTGATGGCGATCGTGCTGCAAGGTTTGTCGGCGCGGCTGGGCATCGCGACCGGGCTGGATCTGGCGCAGGCCTGTCGCGT
GCGTTATCCGCGTGGCGTCAACCTGGCGCTGTGGGGCATTTGCGAACTGGCCATCATCGCCTGCGATCTGGCCGAGGTCA
TCGGTACCGCGATTGCGTTGAAGCTGTTGTTCGGGATTCCGCTCACCCTGGGCGCGATCATCACCGCGGTGGATGTGGTG
CTGGTGTTGCTGCTGATGAACCGCGGCTTCCGCGCGCTGGAAGCCTTCGTGATCGCGCTGCTGCTGATCATCTTCGTGTG
TTTCGGCATCCAGATCGCGCTGGCCGCACCGCCGGTTGCGGCAGTCCTGGGCGGTTTCATTCCGCGTGCGCAGGTGGTCA
CCGACCCGCAGGCGCTGTATCTGGCGATCGGCATCATCGGGGCGACGGTGATGCCACACAACCTGTATCTGCATTCCTCG
ATCGTGCAGACGCGCGCGTATCCGCGGACCGATGTCGGCCGGAAATCGGCGCTGCGTTGGGCGGTCACCGACAGCACCGT
GGCGTTGATGTTCGCGTTGTTCATCAATGCCTCGATCCTGATCCTGGCTGCGGCGGTGTTCCATGCGCAGGGCCGCACCG
ACGTGCAGGAGATCGAACAGGCGCATGCGTTGCTGGCGCCGATGCTGGGCGTCGGCCTGGCCTCGACGCTGTTTGCGGTG
GCGCTGCTCGCCTCGGGCATCAACTCCACCGTGACCGCAACGTTGGCCGGGCAGATCGTGATGGAAGGTTTCCTGCAATT
ACGCCTGCCGCCGTGGATACGGCGCTTGCTCACCCGTGGTATCGCCATCGTGCCGGTGGTCATCGTGACCTGGCTGTATG
GCGAAGCCGGTACCGCACGGTTGTTGGTACTCAGCCAGGTGGTGTTGTCGATGCAGCTGCCGTTTGCGGTGATTCCGCTG
GTGCGCTTCGTGTCGGACCGGCAGTTGATGGGCGCGCTGGTAGCGCCAGCGTGGCTGGTACGCATCGCGTGGGTGATCGC
GGCAGTGATCGTATGCCTCAATCTGAAGCTGCTGTGGGATACCGCGCTGCATTGA

Upstream 100 bases:

>100_bases
TAGTTTGAAGCACACGACAGATCAATACGATTCAAATTGCCAATGCTCAACAGCATAGCAACTGCTATATCATGCATTGA
CCCCGTTGTGACCCGAGTGC

Downstream 100 bases:

>100_bases
GATGCGGCATTGGCTCGGGTGTTGCACCGGCGTTCGATCAATTGTTTCGTATCGCCCGGACAGCTGGAAGACGACGTCGC
GCTTTCTTGCCTTCAACGCG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSANTAASAPSPATATGGLGDHQASVSVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSN
LMAIVLQGLSARLGIATGLDLAQACRVRYPRGVNLALWGICELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITAVDVV
LVLLLMNRGFRALEAFVIALLLIIFVCFGIQIALAAPPVAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAV
ALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRGIAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPL
VRFVSDRQLMGALVAPAWLVRIAWVIAAVIVCLNLKLLWDTALH

Sequences:

>Translated_444_residues
MSANTAASAPSPATATGGLGDHQASVSVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSN
LMAIVLQGLSARLGIATGLDLAQACRVRYPRGVNLALWGICELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITAVDVV
LVLLLMNRGFRALEAFVIALLLIIFVCFGIQIALAAPPVAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAV
ALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRGIAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPL
VRFVSDRQLMGALVAPAWLVRIAWVIAAVIVCLNLKLLWDTALH
>Mature_443_residues
SANTAASAPSPATATGGLGDHQASVSVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSNL
MAIVLQGLSARLGIATGLDLAQACRVRYPRGVNLALWGICELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITAVDVVL
VLLLMNRGFRALEAFVIALLLIIFVCFGIQIALAAPPVAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSSI
VQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAVA
LLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRGIAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLV
RFVSDRQLMGALVAPAWLVRIAWVIAAVIVCLNLKLLWDTALH

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI295293167, Length=466, Percent_Identity=36.6952789699571, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI295293175, Length=466, Percent_Identity=36.6952789699571, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI295293173, Length=466, Percent_Identity=36.6952789699571, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI10835169, Length=466, Percent_Identity=36.6952789699571, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI295293178, Length=466, Percent_Identity=36.6952789699571, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI295293171, Length=466, Percent_Identity=36.6952789699571, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI295293169, Length=466, Percent_Identity=36.6952789699571, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI109255241, Length=427, Percent_Identity=37.9391100702576, Blast_Score=226, Evalue=5e-59,
Organism=Escherichia coli, GI1788736, Length=406, Percent_Identity=41.6256157635468, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI193210616, Length=454, Percent_Identity=32.8193832599119, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71999499, Length=446, Percent_Identity=32.9596412556054, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17569473, Length=367, Percent_Identity=35.6948228882834, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71993856, Length=229, Percent_Identity=37.9912663755458, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323062, Length=413, Percent_Identity=42.1307506053269, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6324450, Length=418, Percent_Identity=38.5167464114833, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321841, Length=405, Percent_Identity=42.7160493827161, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI45553443, Length=409, Percent_Identity=35.9413202933985, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24648607, Length=440, Percent_Identity=34.7727272727273, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI281362176, Length=440, Percent_Identity=34.7727272727273, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24648609, Length=440, Percent_Identity=34.7727272727273, Blast_Score=230, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 47011; Mature: 46880

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANTAASAPSPATATGGLGDHQASVSVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHH
DLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRVRYPRGVNLALWGI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHH
CELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITAVDVVLVLLLMNRGFRALEAFVIAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLIIFVCFGIQIALAAPPVAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
HHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCHHHHHHH
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQ
HHHHCCCCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AHALLAPMLGVGLASTLFAVALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVSDRQLMGALVAPAWLV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RIAWVIAAVIVCLNLKLLWDTALH
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SANTAASAPSPATATGGLGDHQASVSVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHH
DLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRVRYPRGVNLALWGI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHH
CELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITAVDVVLVLLLMNRGFRALEAFVIAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLIIFVCFGIQIALAAPPVAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
HHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCHHHHHHH
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQ
HHHHCCCCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AHALLAPMLGVGLASTLFAVALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVSDRQLMGALVAPAWLV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RIAWVIAAVIVCLNLKLLWDTALH
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]