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The map label for this gene is vdh [H]

Identifier: 78047737

GI number: 78047737

Start: 2508298

End: 2509479

Strand: Reverse

Name: vdh [H]

Synonym: XCV2181

Alternate gene names: 78047737

Gene position: 2509479-2508298 (Counterclockwise)

Preceding gene: 78047738

Following gene: 78047736

Centisome position: 48.46

GC content: 64.38

Gene sequence:

>1182_bases
ATGAATGCCTTGAGTCGCATCAGCAGCGATATCGATCTGTTTACCGACGACGCGTTGCACGACCCCTACCCGCTCTATGC
CGAACTGCGCAATCTCGGGCCTGCCGCCTACCTGCGCACCTATGACCTCTACTACCTGGGCCGCTACGAGCAGGTGCGCA
AGGCGCTGATGGATTGGCAGACATTTTCGTCCGCGCAGGGCGCCGGGCTCAATCCGGTCATCAACAAGCAGTGGGAACAC
GCGCTGATCTGCGTCGATCCGCCCATGCACGGTGGCACCCGCAAGCTGTTCACCGAACGTCTCGGTCCACGCCATCTGCA
GCACGTCCAAGACACCATCCATCAACGCGCCGACGAACTGGCAAGAAGCCTGCAGCAGCGCGAGCAGTTCGATGGCGTAC
GCGACGTCGCCCACGACCTGCCGGTCAATGTCATTTTCGATCTGATCGGATGGCCGGAAGAAGCGCGCGGCGAACTGGCG
GCGCTGGCCGCCGGCTGCTTCGATGCCTGTGGCCCGGACTCCTTACGCATGCGAGCGGCCCTGCCACGCCTTGAAGCGAT
GCGGGCATTCGTCGCCGACACCTACGACCGCGATCGGCTTACGCCCGGTGGCTTCGGTTCCACGGTCGCCGCCGCCGGCA
AGCGCGGCGAGATCCCGCGCGAAGCGGCCATCGGCCTGATGGAGGGCTATGTGATCGCCGCCTTCGACACCACGATCAAT
GCCATCAGCAATGGGCTATGGCAGTTCGCGCAACATCCCGAGCAGTGGGAAAGGTTGCGCCAGGATCCGGGCAAAGCACC
TGCCGCCTTCCAGGAGATCGTCCGCATCGACAGCCCGCTGCAGCACCTCTCGCGCGTGACCACCCGCCAGGTCGATCTGG
GCGAAGGTGTCGTGCTTCCCGCAGGCGCGCGGGTGATCGTGAGCTATGCCTCGGCCAATCGCGACGAACGCCATTATCCG
GAACCGGACCGCTTCGATATCGAGCGCAACCCCGTCGATCACCTGGGATTTGGGCTGGCGACGCACAATTGCGCAGGCCA
GGCGCTCGCCAAGCTGGAAGGGATGGCCACATTCGCAGCGTTGGCCCGCTACATCGACCACTTCACGCTGACCGGGCCGG
TGCAACGCATTCCCAACAGCATCACCCGTGGGCTGTCGCATCTGCCCATGCGCGCGCACTAG

Upstream 100 bases:

>100_bases
TCAAGTTTGCTTCGTCGCTCGCCAAGCGCTGCCGCCGTCGCGCTCTCTAAGCTGCGCGTGCCCATGTCGGGTACGAACCA
CCAGCCGGAGGCGGCACCGC

Downstream 100 bases:

>100_bases
GAAGCGACCATGCCCACCATCACCTACATCGAACCGAGCGGCGAGACCGTGGCGGTCGACCTCGCGCCGGGATGGACCCT
GATGCAAGGGGCCATGCATC

Product: cytochrome P-450

Products: NA

Alternate protein names: Cytochrome P450 [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNALSRISSDIDLFTDDALHDPYPLYAELRNLGPAAYLRTYDLYYLGRYEQVRKALMDWQTFSSAQGAGLNPVINKQWEH
ALICVDPPMHGGTRKLFTERLGPRHLQHVQDTIHQRADELARSLQQREQFDGVRDVAHDLPVNVIFDLIGWPEEARGELA
ALAAGCFDACGPDSLRMRAALPRLEAMRAFVADTYDRDRLTPGGFGSTVAAAGKRGEIPREAAIGLMEGYVIAAFDTTIN
AISNGLWQFAQHPEQWERLRQDPGKAPAAFQEIVRIDSPLQHLSRVTTRQVDLGEGVVLPAGARVIVSYASANRDERHYP
EPDRFDIERNPVDHLGFGLATHNCAGQALAKLEGMATFAALARYIDHFTLTGPVQRIPNSITRGLSHLPMRAH

Sequences:

>Translated_393_residues
MNALSRISSDIDLFTDDALHDPYPLYAELRNLGPAAYLRTYDLYYLGRYEQVRKALMDWQTFSSAQGAGLNPVINKQWEH
ALICVDPPMHGGTRKLFTERLGPRHLQHVQDTIHQRADELARSLQQREQFDGVRDVAHDLPVNVIFDLIGWPEEARGELA
ALAAGCFDACGPDSLRMRAALPRLEAMRAFVADTYDRDRLTPGGFGSTVAAAGKRGEIPREAAIGLMEGYVIAAFDTTIN
AISNGLWQFAQHPEQWERLRQDPGKAPAAFQEIVRIDSPLQHLSRVTTRQVDLGEGVVLPAGARVIVSYASANRDERHYP
EPDRFDIERNPVDHLGFGLATHNCAGQALAKLEGMATFAALARYIDHFTLTGPVQRIPNSITRGLSHLPMRAH
>Mature_393_residues
MNALSRISSDIDLFTDDALHDPYPLYAELRNLGPAAYLRTYDLYYLGRYEQVRKALMDWQTFSSAQGAGLNPVINKQWEH
ALICVDPPMHGGTRKLFTERLGPRHLQHVQDTIHQRADELARSLQQREQFDGVRDVAHDLPVNVIFDLIGWPEEARGELA
ALAAGCFDACGPDSLRMRAALPRLEAMRAFVADTYDRDRLTPGGFGSTVAAAGKRGEIPREAAIGLMEGYVIAAFDTTIN
AISNGLWQFAQHPEQWERLRQDPGKAPAAFQEIVRIDSPLQHLSRVTTRQVDLGEGVVLPAGARVIVSYASANRDERHYP
EPDRFDIERNPVDHLGFGLATHNCAGQALAKLEGMATFAALARYIDHFTLTGPVQRIPNSITRGLSHLPMRAH

Specific function: Hydroxylates vitamin D(3) into 25-hydroxyvitamin D(3) and 1-alpha,25-dihydroxyvitamin D(3), its physiologically active forms. It first hydroxylates the C-25 position of vitamin D(3) to form 25-hydroxyvitamin D(3), then subsequently hydroxylates the C- 1-a

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: =1.14.13.15 [H]

Molecular weight: Translated: 43733; Mature: 43733

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALSRISSDIDLFTDDALHDPYPLYAELRNLGPAAYLRTYDLYYLGRYEQVRKALMDWQ
CCHHHHHCCCCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
TFSSAQGAGLNPVINKQWEHALICVDPPMHGGTRKLFTERLGPRHLQHVQDTIHQRADEL
HHCCCCCCCCCCHHCCCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ARSLQQREQFDGVRDVAHDLPVNVIFDLIGWPEEARGELAALAAGCFDACGPDSLRMRAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LPRLEAMRAFVADTYDRDRLTPGGFGSTVAAAGKRGEIPREAAIGLMEGYVIAAFDTTIN
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCEEEEEHHHHHH
AISNGLWQFAQHPEQWERLRQDPGKAPAAFQEIVRIDSPLQHLSRVTTRQVDLGEGVVLP
HHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEC
AGARVIVSYASANRDERHYPEPDRFDIERNPVDHLGFGLATHNCAGQALAKLEGMATFAA
CCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LARYIDHFTLTGPVQRIPNSITRGLSHLPMRAH
HHHHHHHCCCCCHHHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNALSRISSDIDLFTDDALHDPYPLYAELRNLGPAAYLRTYDLYYLGRYEQVRKALMDWQ
CCHHHHHCCCCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
TFSSAQGAGLNPVINKQWEHALICVDPPMHGGTRKLFTERLGPRHLQHVQDTIHQRADEL
HHCCCCCCCCCCHHCCCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ARSLQQREQFDGVRDVAHDLPVNVIFDLIGWPEEARGELAALAAGCFDACGPDSLRMRAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LPRLEAMRAFVADTYDRDRLTPGGFGSTVAAAGKRGEIPREAAIGLMEGYVIAAFDTTIN
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCEEEEEHHHHHH
AISNGLWQFAQHPEQWERLRQDPGKAPAAFQEIVRIDSPLQHLSRVTTRQVDLGEGVVLP
HHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEC
AGARVIVSYASANRDERHYPEPDRFDIERNPVDHLGFGLATHNCAGQALAKLEGMATFAA
CCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LARYIDHFTLTGPVQRIPNSITRGLSHLPMRAH
HHHHHHHCCCCCHHHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA