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The map label for this gene is pyrD [H]

Identifier: 78047391

GI number: 78047391

Start: 2072738

End: 2073793

Strand: Reverse

Name: pyrD [H]

Synonym: XCV1835

Alternate gene names: 78047391

Gene position: 2073793-2072738 (Counterclockwise)

Preceding gene: 78047392

Following gene: 78047390

Centisome position: 40.05

GC content: 66.38

Gene sequence:

>1056_bases
ATGTATTCGCTTGCCCGCCCCTTCCTATTTTCCCTGGATGCCGAGCGCGCCCACGCGCTGGCGTTGCGCTCCATCGACAC
CGCCTACCGCACCGGCACCACGGCATTGCTGGCCAGGCGCCCGGTGCCGCTGCCCACTCCGGCCTTCGGCCTGATATTCC
CCAACCCGGTCGGGCTGGGTGCCGGGCTGGACAAGAACGGTGAGCACATCGATGCGTTGTTTGCGCTGGGCTTCGGCTTT
GTCGAGATCGGCACGGTGACGCCGCGCGCGCAGGAGGGCAACCCGAAGCCACGCATGTTCCGATTGCCGGAATACCAGGC
GGTGATCAACCGCATGGGCTTCAACAATCTGGGCGTGGATGCGCTGGTGGCCAACGTGCAGCGCGCACGCCGCACGGGAG
GCCTGCTCGGCATCAACATCGGCAAGAACAAGGACACGCCCAACGAGGAGGCCACCAGTGACTACCGTTACTGCATGGAG
CGCGTGTATCCGCTGGCCGACTACATCACGGTCAACATCTCCTCGCCCAATACTGCGGGCTTGCGCGAGTTGCAGGAAGA
ACAATCGCTGCGCCGTCTGATTTCCGACTTGCGCGAAACCCAGGAAGTGCTAAGCGCGCCACACGGCAAACGGGTGCCGA
TGCTGGTCAAGGTGGCGCCGGACCTCAACGACCGCGACATCGATGCCGCCGCACGCGTGCTGGCCGACCTGGCAGTGGAT
GGCGTGATCGCCACCAACACCACGGTGACGCGCACGCTGGTGGCCAATCACCCGCTGGCTGCCGAAGCCGGCGGTCTGTC
CGGCGCGCCGCTGCTGGGGCAATCCACGCTGGTGCTGCGGCGCCTGCGCGCGCGCCTGCCCGAATCGATTCCGTTGATTG
GCGTGGGCGGCATCAACTCCGGCGCCGATGCGGTGGCCAAGATGGCAGCCGGTGCGAGCCTGGTGCAGTGCTACAGCGGG
TTGGTGTATCGCGGCCCGCAGCTCATCGGCGAATGCGTCAACGCCATCCGACGCCGTCGCGAAGCACCCAGCGGCGGTGC
GGTGTCGCCGTTATGA

Upstream 100 bases:

>100_bases
TCGCCGCACTCCGCACGTTGTTCGATGCATATGCGCACGATGGGCTGATCGACTTCCAATACCAAACCCGCGTGTTCGCC
GGGAGATTGAACTGACCCGC

Downstream 100 bases:

>100_bases
GCGATGCAGTGCACACAGGCTGGCAGCTGAGCGAACAGGCGCCGCTGCGCGCGCTCAACACCTTCCATGTGGAGGCCACC
GCGCGCTGGTTGCTCAACGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLIFPNPVGLGAGLDKNGEHIDALFALGFGF
VEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRTGGLLGINIGKNKDTPNEEATSDYRYCME
RVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEVLSAPHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSG
LVYRGPQLIGECVNAIRRRREAPSGGAVSPL

Sequences:

>Translated_351_residues
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLIFPNPVGLGAGLDKNGEHIDALFALGFGF
VEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRTGGLLGINIGKNKDTPNEEATSDYRYCME
RVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEVLSAPHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSG
LVYRGPQLIGECVNAIRRRREAPSGGAVSPL
>Mature_351_residues
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLIFPNPVGLGAGLDKNGEHIDALFALGFGF
VEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRTGGLLGINIGKNKDTPNEEATSDYRYCME
RVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEVLSAPHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSG
LVYRGPQLIGECVNAIRRRREAPSGGAVSPL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=343, Percent_Identity=46.064139941691, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=52.2388059701493, Blast_Score=327, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17509475, Length=342, Percent_Identity=40.0584795321637, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI281361352, Length=332, Percent_Identity=42.7710843373494, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17137316, Length=332, Percent_Identity=42.7710843373494, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37520; Mature: 37520

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLIFPNPVGLG
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
AGLDKNGEHIDALFALGFGFVEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVD
CCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHH
ALVANVQRARRTGGLLGINIGKNKDTPNEEATSDYRYCMERVYPLADYITVNISSPNTAG
HHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHH
LRELQEEQSLRRLISDLRETQEVLSAPHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHC
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINS
CEEECCCCEEHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
GADAVAKMAAGASLVQCYSGLVYRGPQLIGECVNAIRRRREAPSGGAVSPL
CHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLIFPNPVGLG
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
AGLDKNGEHIDALFALGFGFVEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVD
CCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHH
ALVANVQRARRTGGLLGINIGKNKDTPNEEATSDYRYCMERVYPLADYITVNISSPNTAG
HHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHH
LRELQEEQSLRRLISDLRETQEVLSAPHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHC
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINS
CEEECCCCEEHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
GADAVAKMAAGASLVQCYSGLVYRGPQLIGECVNAIRRRREAPSGGAVSPL
CHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]