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The map label for this gene is murB [H]

Identifier: 78047390

GI number: 78047390

Start: 2071689

End: 2072741

Strand: Reverse

Name: murB [H]

Synonym: XCV1834

Alternate gene names: 78047390

Gene position: 2072741-2071689 (Counterclockwise)

Preceding gene: 78047391

Following gene: 78047389

Centisome position: 40.03

GC content: 66.67

Gene sequence:

>1053_bases
ATGAGCGATGCAGTGCACACAGGCTGGCAGCTGAGCGAACAGGCGCCGCTGCGCGCGCTCAACACCTTCCATGTGGAGGC
CACCGCGCGCTGGTTGCTCAACGTCCACGCGCCCGAGGCATTGCCGCAGGCATTGGCCGCGCCCGAGATCGCCGGACAAC
CGTTGCTGGTGCTGGGCAGCGGCAGCAATGTCTTGCTAGCCGGCGATCCGCCCGGCTGCGTGCTGTGCTTCGACAACCGC
CAGACTTCCATCATCGCGCACCGTGCCGACCACGCCATCGTGCGGGCCGGCGCCGGCGTGAACTGGCATGCGCTGGTGCT
GTACTCGCTGCAGCAGGGCTTGTCGGGGCTGGAAAATCTGGCACTGATTCCGGGCACCGTGGGCGCCTGCCCGATCCAGA
ACATCGGCGCGTACGGCGCGCAGGTGGGCGACTTCATCCACGTGGTGGAAGCCTTCGACCGGCATAGCCAGCAGTTCGTG
CGGCTGGATGCGGCCGACTGCGCGTTCGGCTACCGCGACAGCGTGTTCAAGCAGCAGCCCGAGCGTTATCTGATCGTGGC
GGTGGAATTCAATCTACCGCTGCTGCACGAACTGCGACTGGACTACGCCGGCATTCGCGAGGAACTGGCGCGCATGGGCG
CCGAACTGGCGGGCGCGGCCGATGTGGCGCAGGCGGTGATCAACATCCGGCGCCGCAAGTTGCCGGACCCGGATGTGCTG
GGCAATGCGGGCAGCTTCTTCAAGAACCCATTGCTGCCGAGCGAACAGATTGCCGCCTTGCAGGCCAGCTTTGCCGACAT
GCCGGTGTATCCGGGCGAGCAGGCCGGCCAGGGCAAATTGTCGGCCGCCTGGCTGATCGAGCAATGCGGCTGGAAAGGCA
GGCGCGAGGGCGATGCCGGCGTGTCGCCCGAGCATGCGCTGGTGCTGGTCAATTACGGCACCGCCACGGGCGCGCAGTTG
CTGGATTTCGCGCGGCGCATTGCCGAGTCGGTGCGCGAGCGCTATTCGGTGATCCTGGAACCGGAACCGCGCATCATCGG
GGCGCATTGGTGA

Upstream 100 bases:

>100_bases
ACAGCGGGTTGGTGTATCGCGGCCCGCAGCTCATCGGCGAATGCGTCAACGCCATCCGACGCCGTCGCGAAGCACCCAGC
GGCGGTGCGGTGTCGCCGTT

Downstream 100 bases:

>100_bases
CCCCAGCGCAGTTATCGCGGCGAGCCGCGCTGTGGATGCTCACCAGTACCTTCGCCTTCGGGTTGATGGCAATCACCATC
CGCCTGGCCTCAAGCACGAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSDAVHTGWQLSEQAPLRALNTFHVEATARWLLNVHAPEALPQALAAPEIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNR
QTSIIAHRADHAIVRAGAGVNWHALVLYSLQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFV
RLDAADCAFGYRDSVFKQQPERYLIVAVEFNLPLLHELRLDYAGIREELARMGAELAGAADVAQAVINIRRRKLPDPDVL
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEQAGQGKLSAAWLIEQCGWKGRREGDAGVSPEHALVLVNYGTATGAQL
LDFARRIAESVRERYSVILEPEPRIIGAHW

Sequences:

>Translated_350_residues
MSDAVHTGWQLSEQAPLRALNTFHVEATARWLLNVHAPEALPQALAAPEIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNR
QTSIIAHRADHAIVRAGAGVNWHALVLYSLQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFV
RLDAADCAFGYRDSVFKQQPERYLIVAVEFNLPLLHELRLDYAGIREELARMGAELAGAADVAQAVINIRRRKLPDPDVL
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEQAGQGKLSAAWLIEQCGWKGRREGDAGVSPEHALVLVNYGTATGAQL
LDFARRIAESVRERYSVILEPEPRIIGAHW
>Mature_349_residues
SDAVHTGWQLSEQAPLRALNTFHVEATARWLLNVHAPEALPQALAAPEIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNRQ
TSIIAHRADHAIVRAGAGVNWHALVLYSLQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFVR
LDAADCAFGYRDSVFKQQPERYLIVAVEFNLPLLHELRLDYAGIREELARMGAELAGAADVAQAVINIRRRKLPDPDVLG
NAGSFFKNPLLPSEQIAALQASFADMPVYPGEQAGQGKLSAAWLIEQCGWKGRREGDAGVSPEHALVLVNYGTATGAQLL
DFARRIAESVRERYSVILEPEPRIIGAHW

Specific function: Cell wall formation [H]

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1790407, Length=334, Percent_Identity=42.814371257485, Blast_Score=241, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C [H]

EC number: =1.1.1.158 [H]

Molecular weight: Translated: 37806; Mature: 37675

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAVHTGWQLSEQAPLRALNTFHVEATARWLLNVHAPEALPQALAAPEIAGQPLLVLGS
CCCCCCCCCCCCCCCCHHHHHEEEEEEEEEEEEEECCCHHHHHHHCCCCCCCCCEEEEEC
GSNVLLAGDPPGCVLCFDNRQTSIIAHRADHAIVRAGAGVNWHALVLYSLQQGLSGLENL
CCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCC
ALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFVRLDAADCAFGYRDSVFKQQP
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCHHHHHHCCC
ERYLIVAVEFNLPLLHELRLDYAGIREELARMGAELAGAADVAQAVINIRRRKLPDPDVL
CEEEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEQAGQGKLSAAWLIEQCGWKGRREGDAG
CCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
VSPEHALVLVNYGTATGAQLLDFARRIAESVRERYSVILEPEPRIIGAHW
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEECCCC
>Mature Secondary Structure 
SDAVHTGWQLSEQAPLRALNTFHVEATARWLLNVHAPEALPQALAAPEIAGQPLLVLGS
CCCCCCCCCCCCCCCHHHHHEEEEEEEEEEEEEECCCHHHHHHHCCCCCCCCCEEEEEC
GSNVLLAGDPPGCVLCFDNRQTSIIAHRADHAIVRAGAGVNWHALVLYSLQQGLSGLENL
CCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCC
ALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFVRLDAADCAFGYRDSVFKQQP
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCHHHHHHCCC
ERYLIVAVEFNLPLLHELRLDYAGIREELARMGAELAGAADVAQAVINIRRRKLPDPDVL
CEEEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEQAGQGKLSAAWLIEQCGWKGRREGDAG
CCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
VSPEHALVLVNYGTATGAQLLDFARRIAESVRERYSVILEPEPRIIGAHW
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]