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The map label for this gene is parE [H]

Identifier: 78047304

GI number: 78047304

Start: 1969474

End: 1971495

Strand: Reverse

Name: parE [H]

Synonym: XCV1748

Alternate gene names: 78047304

Gene position: 1971495-1969474 (Counterclockwise)

Preceding gene: 78047313

Following gene: 78047303

Centisome position: 38.07

GC content: 62.71

Gene sequence:

>2022_bases
GTGGGGACGCTTGATTGCGAAACCAACGCCAGGGTAGCCAATGCTGCCCGGCCCCCCACTGAACGCCGGTCGCGTGCAAA
AAATCGGCTCAGCCCCCACACTTGCGCGTCGTTTCACGTGCCAACGAGATGCATGAACACCCGTTATAACGCCGCCGATA
TTGAAGTGCTGTCGGGCCTGGACCCGGTCAAACGCCGCCCCGGCATGTATACCGACACCGCGCGCCCGAACCATCTGGCG
CAGGAAGTGATCGACAACTCTGTCGACGAGGCGCTGGCCGGCCACGCCAAGCAGGTCGAAGTCACGCTGTACAAGGACGG
TAGCTGCGAAGTGTCCGACGACGGCCGCGGCATGCCGGTGGACATCCATCCGGAAGAGAAGATTCCGGGCGTGGAGCTGA
TCCTGACCCGGCTGCATGCCGGCGGCAAGTTCAGCAACCGCAACTACACCTTCTCCGGTGGCTTGCACGGTGTAGGCGTA
AGCGTGGTCAACGCGCTGTCGACCAAGGTCGAACTGTTCATCAAGCGCGAAGGCAGCGAGCACCGCATGGAGTTTCGCGA
TGGCAACGCCGCGTCCAAGCTGGAAGTGGTGGGTACCGTCGGCAAGAAAAATACCGGCACGCGGCTGCGTTTCTGGGCCG
ACCCCAAGTATTTCGATACGCCCAAATTCAATGTGCGTGCGTTGCGGCACCTGCTGCGCGCCAAGGCGGTGCTGTGCCCC
GGCCTGACCGTCAAATTGCACGACGAGGCGACCGGCGAGCAGGACAGCTGGTATTTCGAAAACGGCCTGCGCGATTACCT
GAAGGGTGAGATGGCCGAGCACGAGCTGCTGCCGGCCGACCTGTTCGTCGGTAGCCTGAAAAAAGACACCGAAATCGTCG
ACTGGGCCGCGGCCTGGGTGCCGGAAGGCGAGCTGGTGCAGGAAAGCTACGTCAACCTGATCCCCACCGCGCAGCATGGC
ACCCACGTCAATGGCCTGCGTTCGGGCCTGACCGATGCGCTGCGCGAGTTCTGCGATTTCCGCAATCTGCTGCCGCGCGG
CGTCAAGCTGGCACCGGAAGATGTCTGGGACCGGGTGACCTTCGTGCTCAGCCTGAAGATGACCGATCCACAGTTTTCCG
GTCAGACCAAGGAACGCCTGTCCTCGCGCCAGGCTGCCGGCTTCATCGAAGGTGCCGCGCACGATGCCTTCAGCCTGTAT
CTCAACCAGAACGTGGAGATCGGCGAGAAGATCGCGCAGATCGCCATCGATCGCGCCAGCGCACGGTTGAAGACCGAAAA
GCAGATCGTCCGCAAGAAGGTCACCCAGGGCCCTGCCCTGCCCGGCAAGCTGGCCGATTGCATCAGCCAGGATCTGTCGC
GTACCGAACTGTTCCTGGTCGAAGGCGATTCGGCCGGCGGCTCGGCCAAGCAGGCGCGCGACAAGGATTTCCAGGCCATC
CTGCCGTTGCGCGGCAAGATCCTCAACACCTGGGAAGTGGCTTCCGGCAGCGTATTGGCCTCCGAGGAAGTGCATAACCT
GGCGATCGCGATCGGTTGCGACCCGGGCAAGGACGACATCACCGGGCTGCGCTACGGCAAGGTGGTGATCCTGGCCGACG
CCGACTCCGATGGCCTGCATATCGCCACGCTGCTGACGGCGCTGTTCCTGCAGCATTTCCCCGCGCTGGTGGCCGCCGGC
CACGTGTTCGTGGCGATGCCGCCCTTGTTCCGTGTCGATGTGGGCAAGCAGGTGTTCTATGCGCTGGACGAAGAAGAAAA
GACCACGCTGCTGGACAAGATCGCGCGCGAAAAGATGAAGGGCCAGATCAGCGTCACCCGCTTCAAGGGCCTAGGCGAAA
TGAATCCGCAGCAGCTGCGCGAATCCACCATCCACCCGGACACGCGTCGACTGGTGCAGCTGACCATCGACGACGGCGAG
CAGACGCGTTCGTTGATGGACATGCTGCTGGCCAAAAAACGCGCAAGCGACCGCAAGCAGTGGCTGGAGACCAAGGGCGA
TCTGGCCTCGCTTGAAGTCTGA

Upstream 100 bases:

>100_bases
GCCATGGCGGGAAGCGCTGCGACTGCGGCCGCACCGAGGGTGAGCATCAGGATGTGCTTGAACTTCATGGCGTCCTCTTT
GGCTTCGGTGACATCCTCAG

Downstream 100 bases:

>100_bases
GTGCTGGAAACCGATAGCCCCTCTCCCACCCAGGCGAGAAGGCACGGCCTGCGCGCGCCTTCGAGCGCCCGCGCCGCAAG
CGCGGGCGGGGCGCAGAGCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MGTLDCETNARVANAARPPTERRSRAKNRLSPHTCASFHVPTRCMNTRYNAADIEVLSGLDPVKRRPGMYTDTARPNHLA
QEVIDNSVDEALAGHAKQVEVTLYKDGSCEVSDDGRGMPVDIHPEEKIPGVELILTRLHAGGKFSNRNYTFSGGLHGVGV
SVVNALSTKVELFIKREGSEHRMEFRDGNAASKLEVVGTVGKKNTGTRLRFWADPKYFDTPKFNVRALRHLLRAKAVLCP
GLTVKLHDEATGEQDSWYFENGLRDYLKGEMAEHELLPADLFVGSLKKDTEIVDWAAAWVPEGELVQESYVNLIPTAQHG
THVNGLRSGLTDALREFCDFRNLLPRGVKLAPEDVWDRVTFVLSLKMTDPQFSGQTKERLSSRQAAGFIEGAAHDAFSLY
LNQNVEIGEKIAQIAIDRASARLKTEKQIVRKKVTQGPALPGKLADCISQDLSRTELFLVEGDSAGGSAKQARDKDFQAI
LPLRGKILNTWEVASGSVLASEEVHNLAIAIGCDPGKDDITGLRYGKVVILADADSDGLHIATLLTALFLQHFPALVAAG
HVFVAMPPLFRVDVGKQVFYALDEEEKTTLLDKIAREKMKGQISVTRFKGLGEMNPQQLRESTIHPDTRRLVQLTIDDGE
QTRSLMDMLLAKKRASDRKQWLETKGDLASLEV

Sequences:

>Translated_673_residues
MGTLDCETNARVANAARPPTERRSRAKNRLSPHTCASFHVPTRCMNTRYNAADIEVLSGLDPVKRRPGMYTDTARPNHLA
QEVIDNSVDEALAGHAKQVEVTLYKDGSCEVSDDGRGMPVDIHPEEKIPGVELILTRLHAGGKFSNRNYTFSGGLHGVGV
SVVNALSTKVELFIKREGSEHRMEFRDGNAASKLEVVGTVGKKNTGTRLRFWADPKYFDTPKFNVRALRHLLRAKAVLCP
GLTVKLHDEATGEQDSWYFENGLRDYLKGEMAEHELLPADLFVGSLKKDTEIVDWAAAWVPEGELVQESYVNLIPTAQHG
THVNGLRSGLTDALREFCDFRNLLPRGVKLAPEDVWDRVTFVLSLKMTDPQFSGQTKERLSSRQAAGFIEGAAHDAFSLY
LNQNVEIGEKIAQIAIDRASARLKTEKQIVRKKVTQGPALPGKLADCISQDLSRTELFLVEGDSAGGSAKQARDKDFQAI
LPLRGKILNTWEVASGSVLASEEVHNLAIAIGCDPGKDDITGLRYGKVVILADADSDGLHIATLLTALFLQHFPALVAAG
HVFVAMPPLFRVDVGKQVFYALDEEEKTTLLDKIAREKMKGQISVTRFKGLGEMNPQQLRESTIHPDTRRLVQLTIDDGE
QTRSLMDMLLAKKRASDRKQWLETKGDLASLEV
>Mature_672_residues
GTLDCETNARVANAARPPTERRSRAKNRLSPHTCASFHVPTRCMNTRYNAADIEVLSGLDPVKRRPGMYTDTARPNHLAQ
EVIDNSVDEALAGHAKQVEVTLYKDGSCEVSDDGRGMPVDIHPEEKIPGVELILTRLHAGGKFSNRNYTFSGGLHGVGVS
VVNALSTKVELFIKREGSEHRMEFRDGNAASKLEVVGTVGKKNTGTRLRFWADPKYFDTPKFNVRALRHLLRAKAVLCPG
LTVKLHDEATGEQDSWYFENGLRDYLKGEMAEHELLPADLFVGSLKKDTEIVDWAAAWVPEGELVQESYVNLIPTAQHGT
HVNGLRSGLTDALREFCDFRNLLPRGVKLAPEDVWDRVTFVLSLKMTDPQFSGQTKERLSSRQAAGFIEGAAHDAFSLYL
NQNVEIGEKIAQIAIDRASARLKTEKQIVRKKVTQGPALPGKLADCISQDLSRTELFLVEGDSAGGSAKQARDKDFQAIL
PLRGKILNTWEVASGSVLASEEVHNLAIAIGCDPGKDDITGLRYGKVVILADADSDGLHIATLLTALFLQHFPALVAAGH
VFVAMPPLFRVDVGKQVFYALDEEEKTTLLDKIAREKMKGQISVTRFKGLGEMNPQQLRESTIHPDTRRLVQLTIDDGEQ
TRSLMDMLLAKKRASDRKQWLETKGDLASLEV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=578, Percent_Identity=25.0865051903114, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI19913408, Length=581, Percent_Identity=24.2685025817556, Blast_Score=123, Evalue=6e-28,
Organism=Escherichia coli, GI1789408, Length=632, Percent_Identity=64.5569620253165, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=552, Percent_Identity=40.5797101449275, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=623, Percent_Identity=24.3980738362761, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=585, Percent_Identity=23.7606837606838, Blast_Score=111, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=229, Percent_Identity=25.764192139738, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=636, Percent_Identity=23.7421383647799, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI17136538, Length=590, Percent_Identity=25.2542372881356, Blast_Score=126, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.- [C]

Molecular weight: Translated: 74345; Mature: 74213

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTLDCETNARVANAARPPTERRSRAKNRLSPHTCASFHVPTRCMNTRYNAADIEVLSGL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHCCC
DPVKRRPGMYTDTARPNHLAQEVIDNSVDEALAGHAKQVEVTLYKDGSCEVSDDGRGMPV
CHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCEEEEEEEEECCCEEECCCCCCCCE
DIHPEEKIPGVELILTRLHAGGKFSNRNYTFSGGLHGVGVSVVNALSTKVELFIKREGSE
ECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHEEEEEEEECCCH
HRMEFRDGNAASKLEVVGTVGKKNTGTRLRFWADPKYFDTPKFNVRALRHLLRAKAVLCP
HCEEECCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
GLTVKLHDEATGEQDSWYFENGLRDYLKGEMAEHELLPADLFVGSLKKDTEIVDWAAAWV
CCEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHC
PEGELVQESYVNLIPTAQHGTHVNGLRSGLTDALREFCDFRNLLPRGVKLAPEDVWDRVT
CCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEE
FVLSLKMTDPQFSGQTKERLSSRQAAGFIEGAAHDAFSLYLNQNVEIGEKIAQIAIDRAS
EEEEEEECCCCCCCCHHHHHHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
ARLKTEKQIVRKKVTQGPALPGKLADCISQDLSRTELFLVEGDSAGGSAKQARDKDFQAI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCCCCEE
LPLRGKILNTWEVASGSVLASEEVHNLAIAIGCDPGKDDITGLRYGKVVILADADSDGLH
CCCCCCEEEEEECCCCCEEECCCCCEEEEEEECCCCCCCCCCEEECEEEEEEECCCCCCH
IATLLTALFLQHFPALVAAGHVFVAMPPLFRVDVGKQVFYALDEEEKTTLLDKIAREKMK
HHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHC
GQISVTRFKGLGEMNPQQLRESTIHPDTRRLVQLTIDDGEQTRSLMDMLLAKKRASDRKQ
CCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WLETKGDLASLEV
HHHCCCCCCCCCC
>Mature Secondary Structure 
GTLDCETNARVANAARPPTERRSRAKNRLSPHTCASFHVPTRCMNTRYNAADIEVLSGL
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHCCC
DPVKRRPGMYTDTARPNHLAQEVIDNSVDEALAGHAKQVEVTLYKDGSCEVSDDGRGMPV
CHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCEEEEEEEEECCCEEECCCCCCCCE
DIHPEEKIPGVELILTRLHAGGKFSNRNYTFSGGLHGVGVSVVNALSTKVELFIKREGSE
ECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHEEEEEEEECCCH
HRMEFRDGNAASKLEVVGTVGKKNTGTRLRFWADPKYFDTPKFNVRALRHLLRAKAVLCP
HCEEECCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
GLTVKLHDEATGEQDSWYFENGLRDYLKGEMAEHELLPADLFVGSLKKDTEIVDWAAAWV
CCEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHC
PEGELVQESYVNLIPTAQHGTHVNGLRSGLTDALREFCDFRNLLPRGVKLAPEDVWDRVT
CCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEE
FVLSLKMTDPQFSGQTKERLSSRQAAGFIEGAAHDAFSLYLNQNVEIGEKIAQIAIDRAS
EEEEEEECCCCCCCCHHHHHHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
ARLKTEKQIVRKKVTQGPALPGKLADCISQDLSRTELFLVEGDSAGGSAKQARDKDFQAI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCCCCEE
LPLRGKILNTWEVASGSVLASEEVHNLAIAIGCDPGKDDITGLRYGKVVILADADSDGLH
CCCCCCEEEEEECCCCCEEECCCCCEEEEEEECCCCCCCCCCEEECEEEEEEECCCCCCH
IATLLTALFLQHFPALVAAGHVFVAMPPLFRVDVGKQVFYALDEEEKTTLLDKIAREKMK
HHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHC
GQISVTRFKGLGEMNPQQLRESTIHPDTRRLVQLTIDDGEQTRSLMDMLLAKKRASDRKQ
CCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WLETKGDLASLEV
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]