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The map label for this gene is oxyR [H]

Identifier: 78046497

GI number: 78046497

Start: 1068756

End: 1069697

Strand: Reverse

Name: oxyR [H]

Synonym: XCV0941

Alternate gene names: 78046497

Gene position: 1069697-1068756 (Counterclockwise)

Preceding gene: 78046498

Following gene: 78046496

Centisome position: 20.66

GC content: 63.06

Gene sequence:

>942_bases
ATGAATCTGCGTGACCTGAAATATCTGGTAGCCCTGGCCGACCACAAGCATTTCGGCCGCGCTGCGTCGGCCTGCTTTGT
CAGCCAGCCGACGCTGTCCACCCAGATCAAGAAACTCGAAGACGAACTCGGCGTGTCGCTGGTGGAGCGTGCGCCGCGCA
AGGTCATGCTGACCCCGGCGGGCCGCGAAGCTGCCGTGCGTGCGCGCAGCATCGTGGCCGAGGTGGAACAGATGAAGGAA
GCCGCACGCCGCAGCCAGGACCCGGAAGCGGGCACGGTACGTCTGGGCATCTTTCCCACCCTGGCCCCGTATTTGTTGCC
GCACGTGGTACCGCGCATCCGCGAGCGTTTTCCGCGTCTGGAACTGCTGCTGATCGAAGAAAAGAGCGACCAGCTGATGC
ACCAGTTGCGCGAAGGCCGGCTGGATGCCGCGCTGCTTGCATTGCCATTGCAGGACGACCAACTGCATGCCGAATTCCTG
TTCGAAGAACCCTTCGTGCTGGCAGTGCCGGAAGGCCACCCGCTGTCGCGACACGACAGCATGACCCTGGACGACTTGTC
CGAGCAGCGCCTGTTGCTGCTGGAAGATGGCCACTGCTTGCGCGACCAGGCACTGGATGTCTGCCACCTGGCCGGGGCGA
TGGAAAAATCCGAATTTCAGGCCACCAGTTTGGAAACCCTGCGCCAGATGGTCGCGGCGAATGTCGGCGTGACCTTGCTG
CCGCTGCTGGCGGTCAAGCCTCCGGTTGCGCGCTCGGAAAACATCCGCCTGATCCGCTTCCGTGAAGACAAGCAGCCCAG
CCGCCGCATTGCGATGGCGTGGCGGCGCAGTTCGGCCATGACCGCGTTTCTGGAGCAGTTGTCGCAACTGTTCAAGGAAT
TGCCCGAGAGCCTGTTCACTCTGGATCAGCCTGCGACGGGACCGAAGGCGGTTGCGGCTTAG

Upstream 100 bases:

>100_bases
GCGGCATAAGCGAGCGCCTGCTTAGCGCCCGGCCGACCCGGGCGCTAAGCTTGCAACACGCGCCAGTCGTTCCCCGTCAC
CGCAATGAAGGCTGCTGCAC

Downstream 100 bases:

>100_bases
GGAATCGGGAATCGGGAATCGGGAATCGTAAAAGCGTGTCGCGGTTGCGATCGCTTTGGCTGTGGTTGGAGGTCTGAAAT
TGGGGCGGCGCGCGAGCGTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPAGREAAVRARSIVAEVEQMKE
AARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRLELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFL
FEEPFVLAVPEGHPLSRHDSMTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGAMEKSEFQATSLETLRQMVAANVGVTLL
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFTLDQPATGPKAVAA

Sequences:

>Translated_313_residues
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPAGREAAVRARSIVAEVEQMKE
AARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRLELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFL
FEEPFVLAVPEGHPLSRHDSMTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGAMEKSEFQATSLETLRQMVAANVGVTLL
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFTLDQPATGPKAVAA
>Mature_313_residues
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPAGREAAVRARSIVAEVEQMKE
AARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRLELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFL
FEEPFVLAVPEGHPLSRHDSMTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGAMEKSEFQATSLETLRQMVAANVGVTLL
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFTLDQPATGPKAVAA

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=292, Percent_Identity=47.6027397260274, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=32.7800829875519, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787530, Length=295, Percent_Identity=26.7796610169492, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=31.8548387096774, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788887, Length=283, Percent_Identity=30.7420494699647, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788748, Length=304, Percent_Identity=25.6578947368421, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693105, Length=257, Percent_Identity=28.7937743190661, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=29.5546558704453, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=27.9835390946502, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789506, Length=280, Percent_Identity=26.4285714285714, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=28.1632653061224, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082132, Length=263, Percent_Identity=26.615969581749, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786401, Length=302, Percent_Identity=27.1523178807947, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790208, Length=245, Percent_Identity=28.9795918367347, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787806, Length=243, Percent_Identity=23.4567901234568, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87081904, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788481, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789639, Length=306, Percent_Identity=23.202614379085, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35108; Mature: 35108

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPA
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEECCC
GREAAVRARSIVAEVEQMKEAARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCE
ELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFLFEEPFVLAVPEGHPLSRHDS
EEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCCCCCCC
MTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGAMEKSEFQATSLETLRQMVAANVGVTLL
CCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFT
HHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDQPATGPKAVAA
CCCCCCCCCCCCC
>Mature Secondary Structure
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPA
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEECCC
GREAAVRARSIVAEVEQMKEAARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCE
ELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFLFEEPFVLAVPEGHPLSRHDS
EEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCCCCCCC
MTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGAMEKSEFQATSLETLRQMVAANVGVTLL
CCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFT
HHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDQPATGPKAVAA
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]