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The map label for this gene is treA [H]

Identifier: 78046216

GI number: 78046216

Start: 743315

End: 744988

Strand: Reverse

Name: treA [H]

Synonym: XCV0660

Alternate gene names: 78046216

Gene position: 744988-743315 (Counterclockwise)

Preceding gene: 78046217

Following gene: 78046215

Centisome position: 14.39

GC content: 67.8

Gene sequence:

>1674_bases
ATGAGTTCTGCCGCGCCCCCGTGCTGCACGTCGCTGCTTGGCCTGTCGCTGAGCATGTTTGTTGCGCCGGGCACGCTGAC
CGCCGCGCCGCTGGACCCTCCGGTCGTCAATGCGCCGGCGCCCACGCCACCCACGCCCGACCTGGCCTACCCGGAACTGT
TCCAGGCCGTGCAGCGCGGTGAGCTGTTCGACGACCAGAAGCACTTTGTCGACTTCCTGCCGCTGCGCGACCCGGCGCTG
ATCAACGCCGACTATCTGGCGCAGCACGATCACCCCGGTTTCGACCTGCGCAAGTTCGTGGATGCCAATTTCGAAGAATC
GCCGCCGGTGCAGACCGACGCGATCCGCCAGGACACCGCGCTGCGCGAGCACATCGACCTGCTGTGGCCCAAGCTGGTGC
GCAGCCAGAACCACGTGCCGCCGCACAGCAGCCTGCTGGCGCTGCCGCATCCGTATGTGGTGCCGGGCGGGCGCTTCCGC
GAGGTGTATTACTGGGATTCCTACTTCACCATGCTGGGCCTGGTGAAGAGCGGCGAAACCACGCTCAGCCGCCAGATGCT
GGACAACTTCGCCTACCTGATCGACACCTACGGGCATATTCCCAACGGCAACCGCACCTACTATCTCAGCCGCTCGCAGC
CGCCGTTCTTCTCCTACATGGTGGAGCTGCAGGCCGGCGTGGAAGGCGAGGCGGTGTATCAGCGCTACCTGCCGCAGTTG
CAGAAGGAATACGCCTACTGGATGCAGGGCAGCGATGACCTGCAGCCCGGCCAGGCCGCGCGCCACGTGGTGCGCCTGGC
CGACGGCAGCGTGCTCAACCGCTATTGGGACGAGCGCGACACCCCGCGCCCGGAAGCCTGGCTGCACGACACCCGTACCG
CCGCAGAAGTGAAAGACCGCCCGGCCGCCGAGGTCTACCGCGACCTGCGTGCCGGCGCCGAAAGTGGCTGGGACTACACC
AGCCGCTGGCTGGCCGACGGCCAGAACCTGCGCACCATCCGCACCACGGCCATCCTCCCGATCGACCTCAACAGCCTGCT
CTACCACCTCGAGCGCACGCTGGCGCAGGCCTGCGCGCAAGCCGGCGCAGAGTGCACCCGCGATTACGCCGCACTTGCAC
AACAGCGCAAGCAGGCCATCGACGCGCATCTGTGGAATGCCGCCGGCTACTACGCCGACTACGACTGGCAGACGCGCACG
CTGAGCAACCAGGTCACCGCCGCCGCGCTGTACCCGCTGTTCGCCGGCCTGGCCTCGGACGATCACGCCAAGCGCACCGC
CAGCACCGTGCGTAAAACGCTGCTGCGCCCCGGCGGCCTGGCGACCACCGCAGTGAAGACCGGCCAGCAATGGGACGAAC
CCAACGGCTGGGCGCCGCTGCAATGGGTGGCCGTGGATGGCCTGCGGCGCTACGGCGAAGACGCGCTGGCACGCACCATT
GGCGAACGTTTTCTGGCCCAGGTGCAGGCGCTGTTCGCACGCGAGCACAAGCTGGTCGAAAAGTACGGCCTGGAGACCGA
TGCGGCCGGCGGCGGCGGTGGCGAATACGCCTTGCAGGACGGCTTCGGCTGGACCAACGGCGTCACCTTGATGCTGCTGA
ACCTGTATCCGGGCAAGGATGCCAAAGCCGCACCCGCCAAGCGCGTGCGCAAGCCCGAGGCGGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CCCCGTGCGAAGCCTGTCGGCGTGCCGGCACCCCGCTCGGTCCCGCCCGCCACATCGGTCGTTTACCATGCCCTACGCCA
CTGCCCGTTCTGGAGATGTC

Downstream 100 bases:

>100_bases
GGGCGGTGCCGCTGCCGCGCAGTGCGTGGCGGCGGCAGGGTCGGATCATTGGCGTCGGGTCTCGGACGGTGCACGTCACC
GATGCGCAGCACCGCCGTCG

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDPPVVNAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPAL
INADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFR
EVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVKDRPAAEVYRDLRAGAESGWDYT
SRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLAQACAQAGAECTRDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRT
LSNQVTAAALYPLFAGLASDDHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKDAKAAPAKRVRKPEAAAR

Sequences:

>Translated_557_residues
MSSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDPPVVNAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPAL
INADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFR
EVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVKDRPAAEVYRDLRAGAESGWDYT
SRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLAQACAQAGAECTRDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRT
LSNQVTAAALYPLFAGLASDDHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKDAKAAPAKRVRKPEAAAR
>Mature_556_residues
SSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDPPVVNAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPALI
NADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFRE
VYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQLQ
KEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVKDRPAAEVYRDLRAGAESGWDYTS
RWLADGQNLRTIRTTAILPIDLNSLLYHLERTLAQACAQAGAECTRDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTL
SNQVTAAALYPLFAGLASDDHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTIG
ERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKDAKAAPAKRVRKPEAAAR

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=539, Percent_Identity=34.8794063079777, Blast_Score=252, Evalue=5e-67,
Organism=Escherichia coli, GI1787447, Length=552, Percent_Identity=52.7173913043478, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1789936, Length=519, Percent_Identity=51.252408477842, Blast_Score=495, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17542196, Length=537, Percent_Identity=31.6573556797021, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI25148109, Length=535, Percent_Identity=31.4018691588785, Blast_Score=239, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI25141398, Length=542, Percent_Identity=31.1808118081181, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17565078, Length=510, Percent_Identity=30.9803921568627, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71987755, Length=424, Percent_Identity=28.0660377358491, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319473, Length=464, Percent_Identity=29.9568965517241, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320204, Length=452, Percent_Identity=28.3185840707965, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656680, Length=534, Percent_Identity=31.6479400749064, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24656675, Length=534, Percent_Identity=31.6479400749064, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24656661, Length=534, Percent_Identity=31.6479400749064, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17933716, Length=534, Percent_Identity=31.6479400749064, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24656670, Length=534, Percent_Identity=31.6479400749064, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24656685, Length=474, Percent_Identity=32.4894514767932, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI22024178, Length=539, Percent_Identity=29.8701298701299, Blast_Score=213, Evalue=4e-55,
Organism=Drosophila melanogaster, GI45551104, Length=373, Percent_Identity=30.8310991957105, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28573474, Length=313, Percent_Identity=28.7539936102236, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 62094; Mature: 61963

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDPPVVNAPAPTPPTPDLAYPELFQAVQRG
CCCCCCHHHHHHHHHHHHHEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
ELFDDQKHFVDFLPLRDPALINADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTA
CCCCCHHHHHHHCCCCCCCEECHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHH
LREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGET
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECCCCCEEEEEEEHHHHHHHHHHHCCCH
TLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVKDR
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHCCHHHHHHHCC
PAAEVYRDLRAGAESGWDYTSRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLAQACAQ
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECHHHHHHHHHHHHHHHHHH
AGAECTRDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTLSNQVTAAALYPLFAGLASD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCCC
AKAAPAKRVRKPEAAAR
CCCCCHHHHCCCHHCCC
>Mature Secondary Structure 
SSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDPPVVNAPAPTPPTPDLAYPELFQAVQRG
CCCCCHHHHHHHHHHHHHEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
ELFDDQKHFVDFLPLRDPALINADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTA
CCCCCHHHHHHHCCCCCCCEECHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHH
LREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGET
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECCCCCEEEEEEEHHHHHHHHHHHCCCH
TLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVKDR
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHCCHHHHHHHCC
PAAEVYRDLRAGAESGWDYTSRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLAQACAQ
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECHHHHHHHHHHHHHHHHHH
AGAECTRDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTLSNQVTAAALYPLFAGLASD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCCC
AKAAPAKRVRKPEAAAR
CCCCCHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]