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The map label for this gene is adk

Identifier: 78045051

GI number: 78045051

Start: 1199484

End: 1200128

Strand: Direct

Name: adk

Synonym: CHY_1340

Alternate gene names: 78045051

Gene position: 1199484-1200128 (Clockwise)

Preceding gene: 78044675

Following gene: 78043498

Centisome position: 49.95

GC content: 42.64

Gene sequence:

>645_bases
GTGAAACTTTTAATCATGGGCCCTCCGGGGGCTGGAAAAGGAACCCAGGCGGAAAAAATTGTTAAAGAGTTTGGTATTAC
CCATATTTCCACCGGCGATATGTTCCGGGCTGCTTTAAAAAATCAAACGCCCCTGGGATTAAAAGCAAAAGAATATATGG
ATAAAGGTGAGCTGGTACCCGATGAAATCGTAATTGCTATGGTGGAAGAAAGAATATCGGCACCGGACTGCGCAAAAGGC
TTTCTTTTGGACGGTTTTCCCCGGACCATACCACAGGCGGAAGCTCTGGATAAAAAGCTTGCCGAAATGGGAATAACCTT
AGATGGTGTGATCAATATTGAAGTTCCGCGGGAAGAATTAATTGAAAGGTTAACTGGGAGAAGGGTCTGTCGCCAGTGCG
GAGCAACCTACCATGTGAAATTCAATCCGCCAAAAGTTGAAGGAGTTTGCGATGCTTGTGGCGGAGAATTATACCAAAGA
AGCGATGATTCTTTAGAAACAGTAAGCAACCGTTTGGATGTCTATGAAGCGCAGACCGCACCTTTAAAAGATTATTATGC
CAAAACCGGTTTGTTGAAAAATATTGATGGTACAAAATCTATTGAAGAAGTATTCGCTTCAATTAAAAATGCTCTCCAAA
AGTAA

Upstream 100 bases:

>100_bases
TATAAAGTTTTGCTTATTGACAGTAAAACCTAAAAGATAGTAAAATTAAGTTCAGAGTTAATGGCAATTTATAGAAAATT
CTTAAAATGGAGGCGGGAGC

Downstream 100 bases:

>100_bases
ACTCTCCCTTTTGGGGAGAGTTTTTTTAAAGGAAGGTAAAGTATGCCTTACAGTAAAATTGCCAACTTCTACGATCTTTT
GTTAAGCGGAGTTCCCGGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKLLIMGPPGAGKGTQAEKIVKEFGITHISTGDMFRAALKNQTPLGLKAKEYMDKGELVPDEIVIAMVEERISAPDCAKG
FLLDGFPRTIPQAEALDKKLAEMGITLDGVINIEVPREELIERLTGRRVCRQCGATYHVKFNPPKVEGVCDACGGELYQR
SDDSLETVSNRLDVYEAQTAPLKDYYAKTGLLKNIDGTKSIEEVFASIKNALQK

Sequences:

>Translated_214_residues
MKLLIMGPPGAGKGTQAEKIVKEFGITHISTGDMFRAALKNQTPLGLKAKEYMDKGELVPDEIVIAMVEERISAPDCAKG
FLLDGFPRTIPQAEALDKKLAEMGITLDGVINIEVPREELIERLTGRRVCRQCGATYHVKFNPPKVEGVCDACGGELYQR
SDDSLETVSNRLDVYEAQTAPLKDYYAKTGLLKNIDGTKSIEEVFASIKNALQK
>Mature_214_residues
MKLLIMGPPGAGKGTQAEKIVKEFGITHISTGDMFRAALKNQTPLGLKAKEYMDKGELVPDEIVIAMVEERISAPDCAKG
FLLDGFPRTIPQAEALDKKLAEMGITLDGVINIEVPREELIERLTGRRVCRQCGATYHVKFNPPKVEGVCDACGGELYQR
SDDSLETVSNRLDVYEAQTAPLKDYYAKTGLLKNIDGTKSIEEVFASIKNALQK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=44.392523364486, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=44.392523364486, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=41.5, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=38.5, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=38.5, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=38.5, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=38.5, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=31.8840579710145, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI7706497, Length=220, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI28144897, Length=217, Percent_Identity=28.110599078341, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28144899, Length=217, Percent_Identity=28.110599078341, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI22749187, Length=215, Percent_Identity=27.4418604651163, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI237858799, Length=127, Percent_Identity=33.0708661417323, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=52.5345622119816, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=40.1869158878505, Blast_Score=171, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=34.1013824884793, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=31.7757009345794, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=26.5402843601896, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=207, Percent_Identity=26.5700483091787, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147457, Length=136, Percent_Identity=27.9411764705882, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=45.1162790697674, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=38.8888888888889, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=27.3148148148148, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=42.654028436019, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=39.6039603960396, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=39.6039603960396, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI221459597, Length=208, Percent_Identity=25.9615384615385, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356893, Length=208, Percent_Identity=25.9615384615385, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=26.5402843601896, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=26.5402843601896, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CARHZ (Q3ACG0)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_360174.1
- HSSP:   P16304
- ProteinModelPortal:   Q3ACG0
- SMR:   Q3ACG0
- STRING:   Q3ACG0
- GeneID:   3728177
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1340
- NMPDR:   fig|246194.3.peg.1385
- TIGR:   CHY_1340
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   CHYD246194:CHY_1340-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- SMART:   SM00343
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23489; Mature: 23489

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLIMGPPGAGKGTQAEKIVKEFGITHISTGDMFRAALKNQTPLGLKAKEYMDKGELVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCH
DEIVIAMVEERISAPDCAKGFLLDGFPRTIPQAEALDKKLAEMGITLDGVINIEVPREEL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHH
IERLTGRRVCRQCGATYHVKFNPPKVEGVCDACGGELYQRSDDSLETVSNRLDVYEAQTA
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHCCCC
PLKDYYAKTGLLKNIDGTKSIEEVFASIKNALQK
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLLIMGPPGAGKGTQAEKIVKEFGITHISTGDMFRAALKNQTPLGLKAKEYMDKGELVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCH
DEIVIAMVEERISAPDCAKGFLLDGFPRTIPQAEALDKKLAEMGITLDGVINIEVPREEL
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHH
IERLTGRRVCRQCGATYHVKFNPPKVEGVCDACGGELYQRSDDSLETVSNRLDVYEAQTA
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHCCCC
PLKDYYAKTGLLKNIDGTKSIEEVFASIKNALQK
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA