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The map label for this gene is prs [H]

Identifier: 78044887

GI number: 78044887

Start: 161577

End: 162518

Strand: Direct

Name: prs [H]

Synonym: CHY_0193

Alternate gene names: 78044887

Gene position: 161577-162518 (Clockwise)

Preceding gene: 78044455

Following gene: 78042985

Centisome position: 6.73

GC content: 47.98

Gene sequence:

>942_bases
ATGAGCCGCTATGATTTAAAAATTTTTTCCGGCAATGCCAATCCAGATTTAGCTCGAGAAATTGCTTCTTTTTTGGGAGT
GGAAGTTGGTGATGCCCGGGTTTCCCGCTTTTCCGACGGGGAAATTCAGGTAAAAATAAATGAAAGCGTCCGGGGGGCGG
ATGTATTTATAATCCAGCCAACCTGTACACCGGTTAATGAAAATTTAATGGAACTGTTGATCTTAATAGATGCGATTAGA
AGGGCTTCGGCACGCAGGATTACTGCGGTGCTGCCGTATTTTGGTTACGCCCGGCAGGACCGGAAAACGAGAGCCCGGGA
TCCGATTACGGCAAAATTGGTATCCAATTTAATAACCGTAAGCGGGGCGCGCCGGGTGATTGCCATGGACCTGCATGCCG
GACAAATTCAGGGCTTTTTTGATATACCGGTTGATCACCTGGTGGGCGTACCGATTTTAGCCAAGTATTTTAATGAAAAG
GGTTTGGAAAATAAGGTGGTGGTTTCTCCCGATTTAGGCGGGGTAACCCGGGCCCGGGATTTGGCCGAGCGGATTGGGGC
GCCAATTGCTATTATCGATAAACGCCGCCCGGAACCCAATGTAGCGGAAATAATGAACATCATTGGAGAAATTGAAGGGA
AAACGGTGATTATGATCGATGATATTATCGACACCGCCGGTACCATTACCCAGGGAGCGCAGGCTCTTATGGAACGGGGG
GCTAAAGAAGTATACGTATGCTGTACCCATCCTATTTTATCCGGTCCGGCGGTGGACCGGCTGGCCAACGCTCCCATTAA
GGAAGTAGTTGTAACCAATACAATACCCCTTCCACCGGAAAAGAAACTGCCCAAAATTAAAGTGTTATCGGTAGCACCCC
TAATGGGTGAAGCGATCCGGCGGATTCATGAAGATTTATCGGTAAGTGAGCTATTTGTTTAA

Upstream 100 bases:

>100_bases
TTTTTTCGTTAAAGCGGCAGGAAGTTTTCCTATTGTAGGAGAATAAAAAAACTGTCGAATTTTGCTCGGAACATGGATTA
AAGTAAATGGAGGTTTAAAG

Downstream 100 bases:

>100_bases
TCGTCCTGCTTTTTGATTATTGCCTTGCCACACCGGGCAAGGTTTTCTTTTATTTTGGAAAAAGTGTGGCTAATTTTTCC
CGGAATGTAGGTAAGGGCTT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSRYDLKIFSGNANPDLAREIASFLGVEVGDARVSRFSDGEIQVKINESVRGADVFIIQPTCTPVNENLMELLILIDAIR
RASARRITAVLPYFGYARQDRKTRARDPITAKLVSNLITVSGARRVIAMDLHAGQIQGFFDIPVDHLVGVPILAKYFNEK
GLENKVVVSPDLGGVTRARDLAERIGAPIAIIDKRRPEPNVAEIMNIIGEIEGKTVIMIDDIIDTAGTITQGAQALMERG
AKEVYVCCTHPILSGPAVDRLANAPIKEVVVTNTIPLPPEKKLPKIKVLSVAPLMGEAIRRIHEDLSVSELFV

Sequences:

>Translated_313_residues
MSRYDLKIFSGNANPDLAREIASFLGVEVGDARVSRFSDGEIQVKINESVRGADVFIIQPTCTPVNENLMELLILIDAIR
RASARRITAVLPYFGYARQDRKTRARDPITAKLVSNLITVSGARRVIAMDLHAGQIQGFFDIPVDHLVGVPILAKYFNEK
GLENKVVVSPDLGGVTRARDLAERIGAPIAIIDKRRPEPNVAEIMNIIGEIEGKTVIMIDDIIDTAGTITQGAQALMERG
AKEVYVCCTHPILSGPAVDRLANAPIKEVVVTNTIPLPPEKKLPKIKVLSVAPLMGEAIRRIHEDLSVSELFV
>Mature_312_residues
SRYDLKIFSGNANPDLAREIASFLGVEVGDARVSRFSDGEIQVKINESVRGADVFIIQPTCTPVNENLMELLILIDAIRR
ASARRITAVLPYFGYARQDRKTRARDPITAKLVSNLITVSGARRVIAMDLHAGQIQGFFDIPVDHLVGVPILAKYFNEKG
LENKVVVSPDLGGVTRARDLAERIGAPIAIIDKRRPEPNVAEIMNIIGEIEGKTVIMIDDIIDTAGTITQGAQALMERGA
KEVYVCCTHPILSGPAVDRLANAPIKEVVVTNTIPLPPEKKLPKIKVLSVAPLMGEAIRRIHEDLSVSELFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=48.2315112540193, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=47.4025974025974, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=46.9453376205788, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.9807073954984, Blast_Score=290, Evalue=9e-79,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=38.3720930232558, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI194018537, Length=347, Percent_Identity=37.1757925072046, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI310128524, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI310115209, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI310118259, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI310119946, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=55.3054662379421, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=48.2315112540193, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=48.2315112540193, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=48.3766233766234, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=48.2315112540193, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=34.9253731343284, Blast_Score=203, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=45.0793650793651, Blast_Score=269, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=44.3037974683544, Blast_Score=267, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=42.2222222222222, Blast_Score=258, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=44.3877551020408, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324511, Length=99, Percent_Identity=43.4343434343434, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=47.588424437299, Blast_Score=296, Evalue=8e-81,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=44.6107784431138, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=36.4145658263305, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=36.4145658263305, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=36.4145658263305, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=36.4145658263305, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651462, Length=205, Percent_Identity=40, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24651464, Length=205, Percent_Identity=40, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI45552010, Length=205, Percent_Identity=40, Blast_Score=150, Evalue=7e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34215; Mature: 34084

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYDLKIFSGNANPDLAREIASFLGVEVGDARVSRFSDGEIQVKINESVRGADVFIIQP
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEECC
TCTPVNENLMELLILIDAIRRASARRITAVLPYFGYARQDRKTRARDPITAKLVSNLITV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHHHH
SGARRVIAMDLHAGQIQGFFDIPVDHLVGVPILAKYFNEKGLENKVVVSPDLGGVTRARD
CCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
LAERIGAPIAIIDKRRPEPNVAEIMNIIGEIEGKTVIMIDDIIDTAGTITQGAQALMERG
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHCCCHHHHHHHHHHHCC
AKEVYVCCTHPILSGPAVDRLANAPIKEVVVTNTIPLPPEKKLPKIKVLSVAPLMGEAIR
CCEEEEEECCCCCCCHHHHHHHCCCHHHEEEECCCCCCCCCCCCCEEEEEECHHHHHHHH
RIHEDLSVSELFV
HHHHHCCHHHHCC
>Mature Secondary Structure 
SRYDLKIFSGNANPDLAREIASFLGVEVGDARVSRFSDGEIQVKINESVRGADVFIIQP
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEECC
TCTPVNENLMELLILIDAIRRASARRITAVLPYFGYARQDRKTRARDPITAKLVSNLITV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHHHH
SGARRVIAMDLHAGQIQGFFDIPVDHLVGVPILAKYFNEKGLENKVVVSPDLGGVTRARD
CCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
LAERIGAPIAIIDKRRPEPNVAEIMNIIGEIEGKTVIMIDDIIDTAGTITQGAQALMERG
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHCCCHHHHHHHHHHHCC
AKEVYVCCTHPILSGPAVDRLANAPIKEVVVTNTIPLPPEKKLPKIKVLSVAPLMGEAIR
CCEEEEEECCCCCCCHHHHHHHCCCHHHEEEECCCCCCCCCCCCCEEEEEECHHHHHHHH
RIHEDLSVSELFV
HHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2555671; 7584024; 9384377; 10742175 [H]