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The map label for this gene is cobM [H]

Identifier: 78044806

GI number: 78044806

Start: 670980

End: 671735

Strand: Direct

Name: cobM [H]

Synonym: CHY_0762

Alternate gene names: 78044806

Gene position: 670980-671735 (Clockwise)

Preceding gene: 78042761

Following gene: 78044220

Centisome position: 27.94

GC content: 45.24

Gene sequence:

>756_bases
GTGAAAGTTTATTTAGTAGGCGCCGGACCTGGAGATCCCGAGTTAATAACTGTTAAAGGGAAAAAACTTTTAGAGGAAGC
TGATTTAATTGTTTATGCAGGCTCCCTGGTTAATCCCGGACTTTTGGAATATGCCAAACCGGAGGCGGTGAAAGTTGATT
CGGCGCCCAGGACTTTAGAAGAAATAGTGGAGATAATGGTCGAGTATGCTCGAGCCGGAAAAGTTGTCGTACGCTTGCAG
ACCGGAGACCCATCCCTCTATGGGGCAGTAGAGGAACAAAAAAGAGCTTTAAAAGCCTATGGAGTTGAGCTGGAATGGGT
GCCGGGAGTTAGCTCTTTTCTTGGTGCGGCTGCCCGCCTGGGTTACGAATTAACCGTTCCAGACGGTACCCAGACGGTAA
TTTTAAGCAGGGTTGCCGGGAGAACACCGGTGCCGGAAAAAGAAAACTTAGAGGAATTGGCTAAAATTGGGTCAACCCTT
GTGCTCTTTTTAAGTGTGGATAAAATCGACGAGGTTGTCGCCCAAATTTCCCGGGTAAGAGCTCTTGATACTCCGGTAGC
GGTAGTTTATAAAGCTACTTTTCCCGAAGAAAAAATTATTACCGGTACTTTAGCGGATATTGCTCAGAAAGTAAAAGAAG
AAAAGATAAACAAAACCGCCCTTATCTTTGTAGGGGAGTTTTTAAATCCGCCCCCTACTCGCTCAAAATTATATGCTCCC
GATTTTACTCATGGTGGGAGAAGAAAAGGTGATTAA

Upstream 100 bases:

>100_bases
AAGAGCTTGGTACCGAAGAGGAAAAAATCTGTTCTTTTAATGAACTTCCCGAAAAAACCGGGTATTTTTCCCTGGCCCTG
GCGAAGAGGGGGACTTAGCC

Downstream 100 bases:

>100_bases
GAATTTAATAATTTTTTACTTTACCGCAGCCGGCGAAACTCTGGCCCGGCGCTTTTTAACCCTAAAGCTTGGGGGGAACG
TTACTCTCTTTTCCGGTAAA

Product: precorrin-4 C11-methyltransferase

Products: S-adenosyl-L-homocysteine; Precorrin 5

Alternate protein names: Cobalt-precorrin-3 methylase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKVYLVGAGPGDPELITVKGKKLLEEADLIVYAGSLVNPGLLEYAKPEAVKVDSAPRTLEEIVEIMVEYARAGKVVVRLQ
TGDPSLYGAVEEQKRALKAYGVELEWVPGVSSFLGAAARLGYELTVPDGTQTVILSRVAGRTPVPEKENLEELAKIGSTL
VLFLSVDKIDEVVAQISRVRALDTPVAVVYKATFPEEKIITGTLADIAQKVKEEKINKTALIFVGEFLNPPPTRSKLYAP
DFTHGGRRKGD

Sequences:

>Translated_251_residues
MKVYLVGAGPGDPELITVKGKKLLEEADLIVYAGSLVNPGLLEYAKPEAVKVDSAPRTLEEIVEIMVEYARAGKVVVRLQ
TGDPSLYGAVEEQKRALKAYGVELEWVPGVSSFLGAAARLGYELTVPDGTQTVILSRVAGRTPVPEKENLEELAKIGSTL
VLFLSVDKIDEVVAQISRVRALDTPVAVVYKATFPEEKIITGTLADIAQKVKEEKINKTALIFVGEFLNPPPTRSKLYAP
DFTHGGRRKGD
>Mature_251_residues
MKVYLVGAGPGDPELITVKGKKLLEEADLIVYAGSLVNPGLLEYAKPEAVKVDSAPRTLEEIVEIMVEYARAGKVVVRLQ
TGDPSLYGAVEEQKRALKAYGVELEWVPGVSSFLGAAARLGYELTVPDGTQTVILSRVAGRTPVPEKENLEELAKIGSTL
VLFLSVDKIDEVVAQISRVRALDTPVAVVYKATFPEEKIITGTLADIAQKVKEEKINKTALIFVGEFLNPPPTRSKLYAP
DFTHGGRRKGD

Specific function: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=231, Percent_Identity=31.6017316017316, Blast_Score=101, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: 2.1.1.133

Molecular weight: Translated: 27201; Mature: 27201

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYLVGAGPGDPELITVKGKKLLEEADLIVYAGSLVNPGLLEYAKPEAVKVDSAPRTLE
CEEEEEECCCCCCCEEEECCHHHHHHCCEEEEECCCCCCCHHHHCCCCEEEECCCHHHHH
EIVEIMVEYARAGKVVVRLQTGDPSLYGAVEEQKRALKAYGVELEWVPGVSSFLGAAARL
HHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHC
GYELTVPDGTQTVILSRVAGRTPVPEKENLEELAKIGSTLVLFLSVDKIDEVVAQISRVR
CEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHH
ALDTPVAVVYKATFPEEKIITGTLADIAQKVKEEKINKTALIFVGEFLNPPPTRSKLYAP
HCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECC
DFTHGGRRKGD
CCCCCCCCCCC
>Mature Secondary Structure
MKVYLVGAGPGDPELITVKGKKLLEEADLIVYAGSLVNPGLLEYAKPEAVKVDSAPRTLE
CEEEEEECCCCCCCEEEECCHHHHHHCCEEEEECCCCCCCHHHHCCCCEEEECCCHHHHH
EIVEIMVEYARAGKVVVRLQTGDPSLYGAVEEQKRALKAYGVELEWVPGVSSFLGAAARL
HHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHC
GYELTVPDGTQTVILSRVAGRTPVPEKENLEELAKIGSTLVLFLSVDKIDEVVAQISRVR
CEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHH
ALDTPVAVVYKATFPEEKIITGTLADIAQKVKEEKINKTALIFVGEFLNPPPTRSKLYAP
HCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECC
DFTHGGRRKGD
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; Precorrin 4

Specific reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]