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The map label for this gene is sdhA1 [H]

Identifier: 78044778

GI number: 78044778

Start: 616081

End: 616980

Strand: Direct

Name: sdhA1 [H]

Synonym: CHY_0701

Alternate gene names: 78044778

Gene position: 616081-616980 (Clockwise)

Preceding gene: 78043987

Following gene: 78043051

Centisome position: 25.65

GC content: 50.33

Gene sequence:

>900_bases
ATGTATTTAGAGTCAATTGAGCAGTTAATTAAAATTGCGAAGGAAAATGGCCAAACCTTGGGGCGCATGGCCTTAATCTT
AGAGGCCAAAGACCGGGAAGTTCCGGAAGAACAACTTTTAAATATCATGCGTGAAAGACTTCAAGTTATGCAATCTGCGG
TGACAGAAGGCCTTCAGGGAAATCGTTCGGTGGGAGGTCTTGTTGGGGGGCAGGCTTTAAAGTATCAGGCCTGGTTTAAT
TCCGGTAAATCATTAGCTTCGGGGGTTTTTGGTAAGGCAATAACCTATGCTTTGGCGGTTAGTGAAGCCAATGCTTCGAT
GGGATTAATTGTGGCAGCACCTACTGCCGGTTCGGCAGGGGTGATACCAGGGGTGCTTTTAAGTATAATGGAAGAGTATG
AAATTCCCGAAGAAAAAGTTATCGAAGGTTTGTATGCCGCCGGGGCGGTGGGGTTGGTGATAGCTTATAAAGCTTCCCTT
TCCGGAGCCCAGGGGGGCTGTCAGGCGGAATGCGGTTCAGCGGCAGCAATGGCGGCGGTGGCAGCAACGGAACTTTTAGG
GGGAAGCCCCGAACAGGCCGCCCATGCCGGAGCCATTGCCCTGAAAGGTATGTTAGGGCTGGTTTGTGATCCCGTGGCAG
GTCTTGTGGAAGTACCCTGTGTAAAACGAAATGTCTCTGCTGCAGTGCAGGCCTTAGCGGCGGTGGATTTGGCTTTAGCC
GGGATAACATCCGCCATTCCTTTAGATGAAGTTATTGGGGCGATGGGGGAAATTGGCCGGGAGTTACCGTTATCCCTTAA
GGAGACTGCCCGAGGGGGACTTGCAGCAACCCCTACCGGGAAGGCTTTAGCTAAAAAAATTTTCGGGCGAAAGGAGGAAA
AAAATGGCGAAAATAATTGA

Upstream 100 bases:

>100_bases
AAACAGACCAGCCCATTGACGAAGAAACCTGCAAAGAAATCAAAAGACTGCCCGGAATTACCGGTGGCTTTATCATTCCA
CCCCTTTAAGGAGGAAGCCG

Downstream 100 bases:

>100_bases
TTTATCCCAGGAAATTTATCAGGGAATGCCTGTTTTTCCCCTGCACCTTACTACGTACATCTTCCAAAACATAACCCATG
AGGAGAGTATTAAAAAAATT

Product: iron-sulfur-dependent L-serine dehydratase subunit alpha

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MYLESIEQLIKIAKENGQTLGRMALILEAKDREVPEEQLLNIMRERLQVMQSAVTEGLQGNRSVGGLVGGQALKYQAWFN
SGKSLASGVFGKAITYALAVSEANASMGLIVAAPTAGSAGVIPGVLLSIMEEYEIPEEKVIEGLYAAGAVGLVIAYKASL
SGAQGGCQAECGSAAAMAAVAATELLGGSPEQAAHAGAIALKGMLGLVCDPVAGLVEVPCVKRNVSAAVQALAAVDLALA
GITSAIPLDEVIGAMGEIGRELPLSLKETARGGLAATPTGKALAKKIFGRKEEKNGENN

Sequences:

>Translated_299_residues
MYLESIEQLIKIAKENGQTLGRMALILEAKDREVPEEQLLNIMRERLQVMQSAVTEGLQGNRSVGGLVGGQALKYQAWFN
SGKSLASGVFGKAITYALAVSEANASMGLIVAAPTAGSAGVIPGVLLSIMEEYEIPEEKVIEGLYAAGAVGLVIAYKASL
SGAQGGCQAECGSAAAMAAVAATELLGGSPEQAAHAGAIALKGMLGLVCDPVAGLVEVPCVKRNVSAAVQALAAVDLALA
GITSAIPLDEVIGAMGEIGRELPLSLKETARGGLAATPTGKALAKKIFGRKEEKNGENN
>Mature_299_residues
MYLESIEQLIKIAKENGQTLGRMALILEAKDREVPEEQLLNIMRERLQVMQSAVTEGLQGNRSVGGLVGGQALKYQAWFN
SGKSLASGVFGKAITYALAVSEANASMGLIVAAPTAGSAGVIPGVLLSIMEEYEIPEEKVIEGLYAAGAVGLVIAYKASL
SGAQGGCQAECGSAAAMAAVAATELLGGSPEQAAHAGAIALKGMLGLVCDPVAGLVEVPCVKRNVSAAVQALAAVDLALA
GITSAIPLDEVIGAMGEIGRELPLSLKETARGGLAATPTGKALAKKIFGRKEEKNGENN

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=183, Percent_Identity=46.9945355191257, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788116, Length=288, Percent_Identity=37.1527777777778, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1789161, Length=183, Percent_Identity=45.3551912568306, Blast_Score=141, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 30514; Mature: 30514

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLESIEQLIKIAKENGQTLGRMALILEAKDREVPEEQLLNIMRERLQVMQSAVTEGLQG
CCHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NRSVGGLVGGQALKYQAWFNSGKSLASGVFGKAITYALAVSEANASMGLIVAAPTAGSAG
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
VIPGVLLSIMEEYEIPEEKVIEGLYAAGAVGLVIAYKASLSGAQGGCQAECGSAAAMAAV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
AATELLGGSPEQAAHAGAIALKGMLGLVCDPVAGLVEVPCVKRNVSAAVQALAAVDLALA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GITSAIPLDEVIGAMGEIGRELPLSLKETARGGLAATPTGKALAKKIFGRKEEKNGENN
HHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYLESIEQLIKIAKENGQTLGRMALILEAKDREVPEEQLLNIMRERLQVMQSAVTEGLQG
CCHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NRSVGGLVGGQALKYQAWFNSGKSLASGVFGKAITYALAVSEANASMGLIVAAPTAGSAG
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
VIPGVLLSIMEEYEIPEEKVIEGLYAAGAVGLVIAYKASLSGAQGGCQAECGSAAAMAAV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
AATELLGGSPEQAAHAGAIALKGMLGLVCDPVAGLVEVPCVKRNVSAAVQALAAVDLALA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GITSAIPLDEVIGAMGEIGRELPLSLKETARGGLAATPTGKALAKKIFGRKEEKNGENN
HHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]