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The map label for this gene is guaB [H]

Identifier: 78044420

GI number: 78044420

Start: 119098

End: 119913

Strand: Direct

Name: guaB [H]

Synonym: CHY_0137

Alternate gene names: 78044420

Gene position: 119098-119913 (Clockwise)

Preceding gene: 78044972

Following gene: 78043882

Centisome position: 4.96

GC content: 38.11

Gene sequence:

>816_bases
ATGATTAAACAAGTACGGGAAGTAATGACCAGAAATCCGGTAACCATTGAGCCGTACAGGAGCTTATGGGATGCCAAGGA
ACTTATGCGTTCGCAAAGGATTGGCGGGCTACCGGTGGTAGAAAATGAAAAGCTAATAGGCATAATCACTTCAAAGGATT
TAATATTTTATCCGGAAAATCGGCTGGTTATTGACGCCATGACCGAAGAGCCGGTGGTCATTGAAGAAAAAGCATATTTA
TTTGACGCATATCAAAAAATGCTGGAAAATAACATCGAAAGGCTTCCGGTAATAGATGAGTCCGGTGCGCTTACGGGTAT
TATAACGAGGAAGGTAATTGAACGGTATATTGGGTCTTATATAGATTCGATGACCGGGTTACCCAAAAAAGAGTATGCTA
TCTATAAATGTCTTAAATTATTGGAGCGGGGAAATTCTTGTACGGTGGCTTTTATCGATTTAAATAATTTTGGGGAATTA
AATAAGCGTTACGGGCATGTAGTAGGTGACCAAATTTTATTAAAAGTTTCTGGAATATTAAAACAGTTAGGGGAAGATGT
TACCGCTGCCCGCTACGGTGGAGATGAATTTATTTTAATCCTGCCCTATGACGAAGTAAAAACAATTAACCTTGTGGATA
AACTGTTATTTCTTCTGGAAAATGATAAATGGCCCTATGATTTAAAGGTCCAGTGTGCGGTGGGAGTAAAGGAGATTAGA
CTTAAAGAAAAAGTCGATATTATCGAAGAAGTTTTTGCCAGTATCAACGAAGCAAGCTTAAAATGTATAGATAGGAAAAA
GGAGATTAAAACATGA

Upstream 100 bases:

>100_bases
TATCGGCAATCTTAGTAGAAGTGGATGCCATTTCCGATGAAAGTTCCATTTTCAAGGGAAGTTTAAACATAATGCTTAAT
ATCAAAAAGGAGATTGAAAT

Downstream 100 bases:

>100_bases
TATTTGTTGACATGATTAACATCCTTTGCTAAAGTAAGATAAAGAAATTTTAAAAAAGCACCTCTTCCAGAACAGGGGAG
GTTTTCTTTTTGAGAAAATA

Product: CBS/GGDEF domain-containing protein

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MIKQVREVMTRNPVTIEPYRSLWDAKELMRSQRIGGLPVVENEKLIGIITSKDLIFYPENRLVIDAMTEEPVVIEEKAYL
FDAYQKMLENNIERLPVIDESGALTGIITRKVIERYIGSYIDSMTGLPKKEYAIYKCLKLLERGNSCTVAFIDLNNFGEL
NKRYGHVVGDQILLKVSGILKQLGEDVTAARYGGDEFILILPYDEVKTINLVDKLLFLLENDKWPYDLKVQCAVGVKEIR
LKEKVDIIEEVFASINEASLKCIDRKKEIKT

Sequences:

>Translated_271_residues
MIKQVREVMTRNPVTIEPYRSLWDAKELMRSQRIGGLPVVENEKLIGIITSKDLIFYPENRLVIDAMTEEPVVIEEKAYL
FDAYQKMLENNIERLPVIDESGALTGIITRKVIERYIGSYIDSMTGLPKKEYAIYKCLKLLERGNSCTVAFIDLNNFGEL
NKRYGHVVGDQILLKVSGILKQLGEDVTAARYGGDEFILILPYDEVKTINLVDKLLFLLENDKWPYDLKVQCAVGVKEIR
LKEKVDIIEEVFASINEASLKCIDRKKEIKT
>Mature_271_residues
MIKQVREVMTRNPVTIEPYRSLWDAKELMRSQRIGGLPVVENEKLIGIITSKDLIFYPENRLVIDAMTEEPVVIEEKAYL
FDAYQKMLENNIERLPVIDESGALTGIITRKVIERYIGSYIDSMTGLPKKEYAIYKCLKLLERGNSCTVAFIDLNNFGEL
NKRYGHVVGDQILLKVSGILKQLGEDVTAARYGGDEFILILPYDEVKTINLVDKLLFLLENDKWPYDLKVQCAVGVKEIR
LKEKVDIIEEVFASINEASLKCIDRKKEIKT

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 31053; Mature: 31053

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQVREVMTRNPVTIEPYRSLWDAKELMRSQRIGGLPVVENEKLIGIITSKDLIFYPEN
CHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCEEEECCC
RLVIDAMTEEPVVIEEKAYLFDAYQKMLENNIERLPVIDESGALTGIITRKVIERYIGSY
EEEEEECCCCCEEEEHHHHHHHHHHHHHHCCHHHCCEECCCCCCHHHHHHHHHHHHHHHH
IDSMTGLPKKEYAIYKCLKLLERGNSCTVAFIDLNNFGELNKRYGHVVGDQILLKVSGIL
HHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
KQLGEDVTAARYGGDEFILILPYDEVKTINLVDKLLFLLENDKWPYDLKVQCAVGVKEIR
HHHCCCHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHH
LKEKVDIIEEVFASINEASLKCIDRKKEIKT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKQVREVMTRNPVTIEPYRSLWDAKELMRSQRIGGLPVVENEKLIGIITSKDLIFYPEN
CHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCEEEECCC
RLVIDAMTEEPVVIEEKAYLFDAYQKMLENNIERLPVIDESGALTGIITRKVIERYIGSY
EEEEEECCCCCEEEEHHHHHHHHHHHHHHCCHHHCCEECCCCCCHHHHHHHHHHHHHHHH
IDSMTGLPKKEYAIYKCLKLLERGNSCTVAFIDLNNFGELNKRYGHVVGDQILLKVSGIL
HHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
KQLGEDVTAARYGGDEFILILPYDEVKTINLVDKLLFLLENDKWPYDLKVQCAVGVKEIR
HHHCCCHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHH
LKEKVDIIEEVFASINEASLKCIDRKKEIKT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]