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The map label for this gene is pyrG

Identifier: 78044367

GI number: 78044367

Start: 108351

End: 109958

Strand: Direct

Name: pyrG

Synonym: CHY_0125

Alternate gene names: 78044367

Gene position: 108351-109958 (Clockwise)

Preceding gene: 78043915

Following gene: 78044938

Centisome position: 4.51

GC content: 45.27

Gene sequence:

>1608_bases
ATGACGAAGTTTATTTTTGTGACCGGAGGAGTAGTTTCGTCACTGGGCAAAGGAATCACCGCAGCATCTTTAGGACGGCT
TTTAAAAAGTCGCGGACTTAAAGTAGCAATTCAAAAATTTGACCCGTACATTAACGTTGACCCTGGTACCATGAGTCCGT
ATCAGCATGGAGAAGTGTTTGTTACCGACGATGGAGCGGAAACCGACCTTGACCTTGGCCATTACGAACGGTTTATCGAT
ATTAATTTAACCAAGAACTCCAACGTCACTACCGGTAAAGTTTACTGGGCGGTAATTAGCAAGGAACGGCGCGGGGATTA
TCTCGGTGGTACCGTTCAGGTTATCCCGCACATTACCAATGAAATTAAAGAAAGGATATTGAGGGTAGCTAAAGAAAGCA
ATCCCGATGTGGTGATAACCGAAATTGGCGGTACGGTTGGGGATATTGAATCCCTGCCTTTTTTAGAGGCAATAAGACAG
CTAAAAAACGATGTGGGAAAAGACAATGTCCTGTACATTCACGTTACTCTGGTTCCTACTTTAAGGGTAACCGGCGAACT
TAAGACCAAACCAACCCAGCACAGCGTCAAGGAATTGCGGAGCATCGGTATTCAACCGGATATAATTGTAGCCCGCTCGG
AGCAGCCTTTATCCAGGGAAATCACCGAAAAAATTGCTCTCTTCTGTGATATTGATAAAAATGCCGTAATTCAGGCGGTG
GATGCATCTAACATTTACGAGGTTCCTTTAAAGCTAAAAGAAGAAGGTTTGGATGATATTGTTATTAAAAAGTTAGGGCT
TACCTGCGGAGAGCCGGATTTGTCGGAATGGGAACAAATCGTCGAGCGGTATAAAAACCCCAAATTTGAAGTAACTATTG
GTATAGTTGGGAAGTACGTATCCCTTCCCGATGCTTATTTAAGTGTGGCCGAAGCTTTACGCCACGCCGGGATTTATCAT
GAAACCCGGGTTAACATCCGCTGGATTGATTCGGAAATGCTGGAAAAAGAGCCGGTGGAAAAATATTTAAGTAACCTTGA
TGGAATATTGGTTCCCGGAGGCTTTGGCGACCGGGGAGTTGAAGGGAAAATCAAGGCCATTCAGTATGCCCGGGAAAACA
AAGTGCCTTATTTGGGCCTGTGTCTTGGCATGCAGACTGCCGTAATTGAGTTTGCCCGAAATGTGGCAGGCCTTAAGGAT
GCCAATAGCTCTGAATTCAAACCGGATGGTCCCCATTCGGTAATTGACCTTTTGCCGGAACAAAAAGAAGTGGAACAGTT
AGGAGGCACCATGCGTTTGGGATTATATCCGTGTAAGCTTGTTCCGGGGACAAAAGCTCATGCTGCTTACGGAGAAGAAA
TTATTTACGAACGCCACCGGCACCGGTATGAGTTTAACAATGAGTACCGGGAATTATTAACCGGTTTAGGTCTGGTAATA
AGTGGTACTTCTCCCGACGGCCGGCTGGTGGAAATAATAGAACTTTCGGACCATCCGTGGTTTGTGGCGACCCAGTTTCA
CCCCGAATTTAAATCAAGACCCAATAGACCCCATCCGCTTTTCCGGGAGTTTATCGGGGCGAGTTTAAAAACCAATAAAT
TGTTTTAG

Upstream 100 bases:

>100_bases
GTTTCAGCTCCGGAGAAAATGTAACTTTTAGCTTGACTTTGGCTCTTTTGGCCGTATAGAATGGAAAAAGTGATTATTTG
GTAGTATTGGGAGGATTAAG

Downstream 100 bases:

>100_bases
GAGATAACCGGCTAACAGTTAGCCGGTAATTTTTTTAAAAAAAGTTAAGACAAAATTCGACATACAATGAAGGAAAATAA
AAGTTTATGGCGAAATTACA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTKFIFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLTKNSNVTTGKVYWAVISKERRGDYLGGTVQVIPHITNEIKERILRVAKESNPDVVITEIGGTVGDIESLPFLEAIRQ
LKNDVGKDNVLYIHVTLVPTLRVTGELKTKPTQHSVKELRSIGIQPDIIVARSEQPLSREITEKIALFCDIDKNAVIQAV
DASNIYEVPLKLKEEGLDDIVIKKLGLTCGEPDLSEWEQIVERYKNPKFEVTIGIVGKYVSLPDAYLSVAEALRHAGIYH
ETRVNIRWIDSEMLEKEPVEKYLSNLDGILVPGGFGDRGVEGKIKAIQYARENKVPYLGLCLGMQTAVIEFARNVAGLKD
ANSSEFKPDGPHSVIDLLPEQKEVEQLGGTMRLGLYPCKLVPGTKAHAAYGEEIIYERHRHRYEFNNEYRELLTGLGLVI
SGTSPDGRLVEIIELSDHPWFVATQFHPEFKSRPNRPHPLFREFIGASLKTNKLF

Sequences:

>Translated_535_residues
MTKFIFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLTKNSNVTTGKVYWAVISKERRGDYLGGTVQVIPHITNEIKERILRVAKESNPDVVITEIGGTVGDIESLPFLEAIRQ
LKNDVGKDNVLYIHVTLVPTLRVTGELKTKPTQHSVKELRSIGIQPDIIVARSEQPLSREITEKIALFCDIDKNAVIQAV
DASNIYEVPLKLKEEGLDDIVIKKLGLTCGEPDLSEWEQIVERYKNPKFEVTIGIVGKYVSLPDAYLSVAEALRHAGIYH
ETRVNIRWIDSEMLEKEPVEKYLSNLDGILVPGGFGDRGVEGKIKAIQYARENKVPYLGLCLGMQTAVIEFARNVAGLKD
ANSSEFKPDGPHSVIDLLPEQKEVEQLGGTMRLGLYPCKLVPGTKAHAAYGEEIIYERHRHRYEFNNEYRELLTGLGLVI
SGTSPDGRLVEIIELSDHPWFVATQFHPEFKSRPNRPHPLFREFIGASLKTNKLF
>Mature_534_residues
TKFIFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDI
NLTKNSNVTTGKVYWAVISKERRGDYLGGTVQVIPHITNEIKERILRVAKESNPDVVITEIGGTVGDIESLPFLEAIRQL
KNDVGKDNVLYIHVTLVPTLRVTGELKTKPTQHSVKELRSIGIQPDIIVARSEQPLSREITEKIALFCDIDKNAVIQAVD
ASNIYEVPLKLKEEGLDDIVIKKLGLTCGEPDLSEWEQIVERYKNPKFEVTIGIVGKYVSLPDAYLSVAEALRHAGIYHE
TRVNIRWIDSEMLEKEPVEKYLSNLDGILVPGGFGDRGVEGKIKAIQYARENKVPYLGLCLGMQTAVIEFARNVAGLKDA
NSSEFKPDGPHSVIDLLPEQKEVEQLGGTMRLGLYPCKLVPGTKAHAAYGEEIIYERHRHRYEFNNEYRELLTGLGLVIS
GTSPDGRLVEIIELSDHPWFVATQFHPEFKSRPNRPHPLFREFIGASLKTNKLF

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=49.1833030852995, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI28559085, Length=538, Percent_Identity=48.5130111524164, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI28559083, Length=538, Percent_Identity=48.5130111524164, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI221316689, Length=538, Percent_Identity=48.5130111524164, Blast_Score=505, Evalue=1e-143,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=57.380073800738, Blast_Score=609, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=41.5435139573071, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=45.3405017921147, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322563, Length=551, Percent_Identity=45.5535390199637, Blast_Score=475, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=49.6350364963504, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=48.0730223123732, Blast_Score=442, Evalue=1e-124,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CARHZ (Q3AFT7)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_358997.1
- HSSP:   P17812
- ProteinModelPortal:   Q3AFT7
- SMR:   Q3AFT7
- STRING:   Q3AFT7
- GeneID:   3727485
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0125
- NMPDR:   fig|246194.3.peg.813
- TIGR:   CHY_0125
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   CHYD246194:CHY_0125-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59725; Mature: 59594

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 507-507 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFIFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLTKNSNVTTGKVYWAVISKERRGDYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEHHHCCCCCCCCEEEHHHHHH
EIKERILRVAKESNPDVVITEIGGTVGDIESLPFLEAIRQLKNDVGKDNVLYIHVTLVPT
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
LRVTGELKTKPTQHSVKELRSIGIQPDIIVARSEQPLSREITEKIALFCDIDKNAVIQAV
EEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEEEEEECCCCCEEEEE
DASNIYEVPLKLKEEGLDDIVIKKLGLTCGEPDLSEWEQIVERYKNPKFEVTIGIVGKYV
CCCCEEECCCHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHH
SLPDAYLSVAEALRHAGIYHETRVNIRWIDSEMLEKEPVEKYLSNLDGILVPGGFGDRGV
CCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
EGKIKAIQYARENKVPYLGLCLGMQTAVIEFARNVAGLKDANSSEFKPDGPHSVIDLLPE
CCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCC
QKEVEQLGGTMRLGLYPCKLVPGTKAHAAYGEEIIYERHRHRYEFNNEYRELLTGLGLVI
HHHHHHCCCEEEECEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEE
SGTSPDGRLVEIIELSDHPWFVATQFHPEFKSRPNRPHPLFREFIGASLKTNKLF
ECCCCCCCEEEEEEECCCCEEEEEEECCHHHCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKFIFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLTKNSNVTTGKVYWAVISKERRGDYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEHHHCCCCCCCCEEEHHHHHH
EIKERILRVAKESNPDVVITEIGGTVGDIESLPFLEAIRQLKNDVGKDNVLYIHVTLVPT
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
LRVTGELKTKPTQHSVKELRSIGIQPDIIVARSEQPLSREITEKIALFCDIDKNAVIQAV
EEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEEEEEECCCCCEEEEE
DASNIYEVPLKLKEEGLDDIVIKKLGLTCGEPDLSEWEQIVERYKNPKFEVTIGIVGKYV
CCCCEEECCCHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHH
SLPDAYLSVAEALRHAGIYHETRVNIRWIDSEMLEKEPVEKYLSNLDGILVPGGFGDRGV
CCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
EGKIKAIQYARENKVPYLGLCLGMQTAVIEFARNVAGLKDANSSEFKPDGPHSVIDLLPE
CCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCC
QKEVEQLGGTMRLGLYPCKLVPGTKAHAAYGEEIIYERHRHRYEFNNEYRELLTGLGLVI
HHHHHHCCCEEEECEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEE
SGTSPDGRLVEIIELSDHPWFVATQFHPEFKSRPNRPHPLFREFIGASLKTNKLF
ECCCCCCCEEEEEEECCCCEEEEEEECCHHHCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA