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The map label for this gene is ndk

Identifier: 78044290

GI number: 78044290

Start: 181954

End: 182403

Strand: Direct

Name: ndk

Synonym: CHY_0215

Alternate gene names: 78044290

Gene position: 181954-182403 (Clockwise)

Preceding gene: 78043977

Following gene: 78042845

Centisome position: 7.58

GC content: 48.22

Gene sequence:

>450_bases
ATGGAACGAACCTTTATCATGGTAAAACCCGATGGAGTGCAAAGGGGATTGGTCGGGGAAATTATTAGCCGTTTTGAAAA
ACGCGGGTTTAAATTAGTGGGATTAAAACTTATGCAAATCAGCCGGGAGCTGGCGGAAACCCACTACGGCGAACATAAGG
GTAAGCCGTTTTTTGAGGGACTGTTGAACTTTATTACCTCGGGACCGGTGGTGGCCATGGTTTGGGAAGGAAAAGAGGTA
ATAGCCACTGCCCGGGAAATGATGGGGGCTACCAATCCCCTAAAAGCCCAGCCGGGGACTATCCGGGGTACCTACGGTAT
CGATGTGGGGAGAAATGTAATTCACGGCTCCGATTCACCGGAGTCGGCTGCCCGGGAAATTGCCCTTTTTTTCAAGGAAG
AAGAACTTCTTAGTTACGAAAAAACTCTCGATACCTGGATTTACGAATAA

Upstream 100 bases:

>100_bases
GAAATAACGATTCACCTGCGGATGTTCTCCAGTAGTTAGAAAGCCTCCCGTTTTCCGGGAGGCTTTTCCAAATACAGAAA
AAGGGGGAGAATATTTTCTT

Downstream 100 bases:

>100_bases
TACCATAAACCCCGTCAAAATTCGGCGGGGTTTTTTCATGCTTAAAACCTTGTAAAAAGCTTTTTCTAATTTACAGTAAT
TTTCGAAAATAATAAAATAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTFIMVKPDGVQRGLVGEIISRFEKRGFKLVGLKLMQISRELAETHYGEHKGKPFFEGLLNFITSGPVVAMVWEGKEV
IATAREMMGATNPLKAQPGTIRGTYGIDVGRNVIHGSDSPESAAREIALFFKEEELLSYEKTLDTWIYE

Sequences:

>Translated_149_residues
MERTFIMVKPDGVQRGLVGEIISRFEKRGFKLVGLKLMQISRELAETHYGEHKGKPFFEGLLNFITSGPVVAMVWEGKEV
IATAREMMGATNPLKAQPGTIRGTYGIDVGRNVIHGSDSPESAAREIALFFKEEELLSYEKTLDTWIYE
>Mature_149_residues
MERTFIMVKPDGVQRGLVGEIISRFEKRGFKLVGLKLMQISRELAETHYGEHKGKPFFEGLLNFITSGPVVAMVWEGKEV
IATAREMMGATNPLKAQPGTIRGTYGIDVGRNVIHGSDSPESAAREIALFFKEEELLSYEKTLDTWIYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=61.744966442953, Blast_Score=197, Evalue=3e-51,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=61.744966442953, Blast_Score=197, Evalue=3e-51,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=60.1351351351351, Blast_Score=193, Evalue=5e-50,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=58.3892617449664, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=58.3892617449664, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=58.3892617449664, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=58.3892617449664, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=58.3892617449664, Blast_Score=191, Evalue=2e-49,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=52.8985507246377, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=39.0977443609023, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=39.0977443609023, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.036496350365, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=35.2941176470588, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.8518518518519, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=49.6350364963504, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=57.0469798657718, Blast_Score=186, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71995094, Length=130, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=61.4864864864865, Blast_Score=201, Evalue=5e-53,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=62.1621621621622, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=36.7647058823529, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CARHZ (Q3AFJ7)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359087.1
- ProteinModelPortal:   Q3AFJ7
- SMR:   Q3AFJ7
- STRING:   Q3AFJ7
- GeneID:   3727407
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0215
- NMPDR:   fig|246194.3.peg.1074
- TIGR:   CHY_0215
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   CHYD246194:CHY_0215-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16738; Mature: 16738

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFIMVKPDGVQRGLVGEIISRFEKRGFKLVGLKLMQISRELAETHYGEHKGKPFFEG
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LLNFITSGPVVAMVWEGKEVIATAREMMGATNPLKAQPGTIRGTYGIDVGRNVIHGSDSP
HHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEECCCCCH
ESAAREIALFFKEEELLSYEKTLDTWIYE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERTFIMVKPDGVQRGLVGEIISRFEKRGFKLVGLKLMQISRELAETHYGEHKGKPFFEG
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LLNFITSGPVVAMVWEGKEVIATAREMMGATNPLKAQPGTIRGTYGIDVGRNVIHGSDSP
HHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEECCCCCH
ESAAREIALFFKEEELLSYEKTLDTWIYE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA