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The map label for this gene is arsB [C]

Identifier: 78043907

GI number: 78043907

Start: 1177528

End: 1178805

Strand: Direct

Name: arsB [C]

Synonym: CHY_1321

Alternate gene names: 78043907

Gene position: 1177528-1178805 (Clockwise)

Preceding gene: 78043161

Following gene: 78044351

Centisome position: 49.03

GC content: 40.92

Gene sequence:

>1278_bases
ATGAGTCAGTCATTAATTGCGTTAACCGTATTTTTTGCAACTTATACCTTAATTATTTCTGAAAAACTACACCGGGCTAT
AGCAGCGCTTTTAGGCGGTACTTTATTAATTGTTTTGGGCGTTTTAAGTCAGGAAAAAGCAATTCACCATATTGACTGGA
ATACCTTGGGCCTATTAATCGGAATGATGATTATTGTCGGCATTACCAAAAAAACAGGAGTCTTTCAGTATTTGGCAGTA
AAAGCGGTTAAATGGGCCAAAGGGGAGCCAGTTTATATTTTAATAGCTCTGGCTACCGTTACCGCCTTTTTATCGGCATT
TTTAGATAACGTTACAACAGTTTTACTAATTGTTCCGGTAACCTTCACTATAACTGACCGGCTGGGGATAAATCCTATTC
CCTTTCTTATTTCACAGGTGTTAGCCAGTAACATCGGCGGTACCGCCACTTTAATCGGTGACCCGCCCAATATTATGATT
GGCAGCCAAACTCATCTGGATTTCCTAGATTTTCTTAAAAATTTAACACCGGTTATTATAGTTATCCATATCGTAACCAT
GTTTCTTTTTTACTTGATTTATTATAAGGAATTTAAAGTACCTGGGGAATTAAAAAAGAAATTACTGGAATTAAATGAAT
TAGATGAAATTAAAGATTTTGCCCTTTTAAAGAAAAGCCTTTTTGTCTTAGGCCTCGTCATTCTTGGCTTTATTTTGCAC
GGTGCACTTGGTTTAGAATCGGCCACCATCGCCTTATTTGGTGCAGCACTTTTATTAACCATCACCCGGGACGAGCCGGA
GGAAGTGCTTTTAACCGTGGAATGGCCTTCCATCTTCTTTTTCCTCGGCTTGTTTATTGTGGTAGGAGGCCTTGTGGAAA
CGGGAGTTATCGACCGGGTAGCCCGCTGGAGCCTGGAAGCCACCAAAGGTAATTTCACTTTAACTGGGATGTTAATTCTC
TGGCTTTCGGCTATAACATCGGCATTTGTTGATAACATCCCCTTTGTGGCCACGATGATTCCGTTAATTCAGAAGATGGG
TGCTTTAGCCGGCATGACACCACAGGCTTTAGAGCCGCTGTGGTGGGCCTTATCTTTAGGGGCCTGCCTGGGCGGCAACG
GTACGATAATCGGTGCTTCAGCTAACGTAATTGTGGCAGGGTTAGCTGAGAAAAACGGCTATCCGATTTCGTTTATTAGC
TTTATGAAATTAGCCTTTCCTTTAATGTTAGTTTCGGTAGTAATTTCCATGGTTTATCTTCTCCTGTTTTACTTTTAA

Upstream 100 bases:

>100_bases
GTTTAAAAGGTGTCAAAAGGCTGTTTTTGGATATCTTATAGTAGTCTTTGACATCTCCTGGGATTTTTTAAAGATTTTTT
GTGAATAAGGAGGAAAATCA

Downstream 100 bases:

>100_bases
AGGAAAAACATATAAATTTTTCAATTGAAAAAATTAGCTTTGAACGCCTTATGAAAAAGGTTATTTGAGTAGGATTTTTA
TTAAATGGTTAAGGAGGAAA

Product: arsenic transporter family protein

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSQSLIALTVFFATYTLIISEKLHRAIAALLGGTLLIVLGVLSQEKAIHHIDWNTLGLLIGMMIIVGITKKTGVFQYLAV
KAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPVTFTITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMI
GSQTHLDFLDFLKNLTPVIIVIHIVTMFLFYLIYYKEFKVPGELKKKLLELNELDEIKDFALLKKSLFVLGLVILGFILH
GALGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRVARWSLEATKGNFTLTGMLIL
WLSAITSAFVDNIPFVATMIPLIQKMGALAGMTPQALEPLWWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFIS
FMKLAFPLMLVSVVISMVYLLLFYF

Sequences:

>Translated_425_residues
MSQSLIALTVFFATYTLIISEKLHRAIAALLGGTLLIVLGVLSQEKAIHHIDWNTLGLLIGMMIIVGITKKTGVFQYLAV
KAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPVTFTITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMI
GSQTHLDFLDFLKNLTPVIIVIHIVTMFLFYLIYYKEFKVPGELKKKLLELNELDEIKDFALLKKSLFVLGLVILGFILH
GALGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRVARWSLEATKGNFTLTGMLIL
WLSAITSAFVDNIPFVATMIPLIQKMGALAGMTPQALEPLWWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFIS
FMKLAFPLMLVSVVISMVYLLLFYF
>Mature_424_residues
SQSLIALTVFFATYTLIISEKLHRAIAALLGGTLLIVLGVLSQEKAIHHIDWNTLGLLIGMMIIVGITKKTGVFQYLAVK
AVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPVTFTITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMIG
SQTHLDFLDFLKNLTPVIIVIHIVTMFLFYLIYYKEFKVPGELKKKLLELNELDEIKDFALLKKSLFVLGLVILGFILHG
ALGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRVARWSLEATKGNFTLTGMLILW
LSAITSAFVDNIPFVATMIPLIQKMGALAGMTPQALEPLWWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFISF
MKLAFPLMLVSVVISMVYLLLFYF

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=508, Percent_Identity=34.8425196850394, Blast_Score=228, Evalue=7e-60,
Organism=Escherichia coli, GI87082277, Length=305, Percent_Identity=25.9016393442623, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787039, Length=374, Percent_Identity=24.8663101604278, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574683, Length=501, Percent_Identity=34.7305389221557, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI28574681, Length=501, Percent_Identity=34.7305389221557, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI28574685, Length=501, Percent_Identity=34.7305389221557, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI28574678, Length=501, Percent_Identity=34.7305389221557, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24581759, Length=501, Percent_Identity=34.7305389221557, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19920704, Length=501, Percent_Identity=34.7305389221557, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45550608, Length=479, Percent_Identity=33.6116910229645, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI221472711, Length=499, Percent_Identity=27.6553106212425, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581764, Length=499, Percent_Identity=27.6553106212425, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI85724998, Length=479, Percent_Identity=27.348643006263, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI62484377, Length=479, Percent_Identity=27.348643006263, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24656008, Length=469, Percent_Identity=27.9317697228145, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 46234; Mature: 46103

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSLIALTVFFATYTLIISEKLHRAIAALLGGTLLIVLGVLSQEKAIHHIDWNTLGLLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHH
GMMIIVGITKKTGVFQYLAVKAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPV
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TFTITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMIGSQTHLDFLDFLKNLTPVII
HHEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHCCHHHHH
VIHIVTMFLFYLIYYKEFKVPGELKKKLLELNELDEIKDFALLKKSLFVLGLVILGFILH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRV
HHHCCCHHHHHHHHHHHHEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ARWSLEATKGNFTLTGMLILWLSAITSAFVDNIPFVATMIPLIQKMGALAGMTPQALEPL
HHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
WWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFISFMKLAFPLMLVSVVISMVYL
HHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLFYF
HHHHC
>Mature Secondary Structure 
SQSLIALTVFFATYTLIISEKLHRAIAALLGGTLLIVLGVLSQEKAIHHIDWNTLGLLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHH
GMMIIVGITKKTGVFQYLAVKAVKWAKGEPVYILIALATVTAFLSAFLDNVTTVLLIVPV
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TFTITDRLGINPIPFLISQVLASNIGGTATLIGDPPNIMIGSQTHLDFLDFLKNLTPVII
HHEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHCCHHHHH
VIHIVTMFLFYLIYYKEFKVPGELKKKLLELNELDEIKDFALLKKSLFVLGLVILGFILH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALGLESATIALFGAALLLTITRDEPEEVLLTVEWPSIFFFLGLFIVVGGLVETGVIDRV
HHHCCCHHHHHHHHHHHHEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ARWSLEATKGNFTLTGMLILWLSAITSAFVDNIPFVATMIPLIQKMGALAGMTPQALEPL
HHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
WWALSLGACLGGNGTIIGASANVIVAGLAEKNGYPISFISFMKLAFPLMLVSVVISMVYL
HHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLFYF
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]