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The map label for this gene is ilvA1 [H]

Identifier: 78043335

GI number: 78043335

Start: 158911

End: 160116

Strand: Direct

Name: ilvA1 [H]

Synonym: CHY_0191

Alternate gene names: 78043335

Gene position: 158911-160116 (Clockwise)

Preceding gene: 78042945

Following gene: 78044455

Centisome position: 6.62

GC content: 47.93

Gene sequence:

>1206_bases
GTGGTAGAAATTAAAGATGTTCAGGAAGCAAGGATTAGGCTATTGGGGGTTGCTCACCGCACTTTAACCGCTTATTCGGC
AACCTTTAGCCGGCTGGCGGGAGCGGAAGTGTATTTTAAATATGAAAACCTGCAAAAAACCGGTTCCTTTAAGCTGAGGG
GAGCTTATAATAAAGTTGCCAGTCTGCCCGTAAAGGAGCGGGAACGGGGCGTTGTAGCGGCCTCGGCGGGTAACCATGCC
CAGGGGGTAGCTTTTGCTTCGTTTAGTGCCGGAATTCCCGCAACTATCGTGATGCCGGAAGGCGCTCCGCTGGCTAAGAT
TCAGGCGACCCAGAGCTACGGAGCAAAGGTAATTTTACACGGGGTTAGCTATGATGATGCTTTTTTAAAAGCGAAAGAAA
TCATGGAAAAGGAAGGAGCAACTTTTGTCCATGCCTTTGACGACCCCAAAGTGATTGCCGGGCAGGGGACCATAGCCTTA
GAAATGCTCGAAGATGTTCCTGAACTGGATATGCTGGTGGCTCCGGTTGGTGGTGGCGGACTGATAGCCGGTCTTGCAGT
GGCAGCGAAAGCGATAAAACCGCATCTGAAAGTCATAGGGGTTCAGGCCAAGGGGGCACCATCGGCGTATGCTTCTTTAA
AAGAACGCAGGAAAGTAACGTTGGCTTCGGTGTCGACAATTGCTGACGGAATTGCCGTCAAAACTCCGGGGGAGTTGACC
TCGAAAATTATTTTTGATTTGGTAGACGACATTGTCCTGGTGGATGATGAGGAAATTGCCCAGGCAATATTAATGATGTT
AGAACGGGGTAAAGTAATGTTAGAAGGAGCAGGAGCGGTGGGGGTGGCAGCGCTTTTAGCCCAGAAAATTCCGGTACGGG
GGCATAAAGTCGGCGTTGTTTTGTCCGGTGGAAATATCGATGTTCATACCATCTCGATCATAATCGAACGGGGTCTGGTA
AAATCCGGTAGATATGTACGGATAAAAACTATTTTAGATGATAAACCGGGAGCCTTACAAAAGCTTTTGGAGTTAATTGC
CAGGGAAAAGGCCAATATAATTTTTATCAACCATGACCGCATTGCTCCCCACGTGCCGATAAAGCAGGCGGAGGTTGAGC
TGGCTCTGGAAACAAGGGATTTATCTCACATTGAAAAAATTCTGGCGGTTTTAAGAGAAGCGGGTTATCAGATTCTACAA
AATTAA

Upstream 100 bases:

>100_bases
TTTTGGCATTGGGGTTGATGTTGATAAACCGGAAGATCTGGAGGTAGCCTTAAGACATTTGCCCTAAGGGGGGCTTTTTT
CTTTTTGAGGAGGGGATTAA

Downstream 100 bases:

>100_bases
GGAGGGCTTTTTAGTGGAAGGAATTATCTTAGCGGCCGGTAAAGGCACGCGAATGAAATCGGATTTACCCAAAGTAGTAC
ACGAAGTTGCCGAAAAACCA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MVEIKDVQEARIRLLGVAHRTLTAYSATFSRLAGAEVYFKYENLQKTGSFKLRGAYNKVASLPVKERERGVVAASAGNHA
QGVAFASFSAGIPATIVMPEGAPLAKIQATQSYGAKVILHGVSYDDAFLKAKEIMEKEGATFVHAFDDPKVIAGQGTIAL
EMLEDVPELDMLVAPVGGGGLIAGLAVAAKAIKPHLKVIGVQAKGAPSAYASLKERRKVTLASVSTIADGIAVKTPGELT
SKIIFDLVDDIVLVDDEEIAQAILMMLERGKVMLEGAGAVGVAALLAQKIPVRGHKVGVVLSGGNIDVHTISIIIERGLV
KSGRYVRIKTILDDKPGALQKLLELIAREKANIIFINHDRIAPHVPIKQAEVELALETRDLSHIEKILAVLREAGYQILQ
N

Sequences:

>Translated_401_residues
MVEIKDVQEARIRLLGVAHRTLTAYSATFSRLAGAEVYFKYENLQKTGSFKLRGAYNKVASLPVKERERGVVAASAGNHA
QGVAFASFSAGIPATIVMPEGAPLAKIQATQSYGAKVILHGVSYDDAFLKAKEIMEKEGATFVHAFDDPKVIAGQGTIAL
EMLEDVPELDMLVAPVGGGGLIAGLAVAAKAIKPHLKVIGVQAKGAPSAYASLKERRKVTLASVSTIADGIAVKTPGELT
SKIIFDLVDDIVLVDDEEIAQAILMMLERGKVMLEGAGAVGVAALLAQKIPVRGHKVGVVLSGGNIDVHTISIIIERGLV
KSGRYVRIKTILDDKPGALQKLLELIAREKANIIFINHDRIAPHVPIKQAEVELALETRDLSHIEKILAVLREAGYQILQ
N
>Mature_401_residues
MVEIKDVQEARIRLLGVAHRTLTAYSATFSRLAGAEVYFKYENLQKTGSFKLRGAYNKVASLPVKERERGVVAASAGNHA
QGVAFASFSAGIPATIVMPEGAPLAKIQATQSYGAKVILHGVSYDDAFLKAKEIMEKEGATFVHAFDDPKVIAGQGTIAL
EMLEDVPELDMLVAPVGGGGLIAGLAVAAKAIKPHLKVIGVQAKGAPSAYASLKERRKVTLASVSTIADGIAVKTPGELT
SKIIFDLVDDIVLVDDEEIAQAILMMLERGKVMLEGAGAVGVAALLAQKIPVRGHKVGVVLSGGNIDVHTISIIIERGLV
KSGRYVRIKTILDDKPGALQKLLELIAREKANIIFINHDRIAPHVPIKQAEVELALETRDLSHIEKILAVLREAGYQILQ
N

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=41.9047619047619, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI19923959, Length=291, Percent_Identity=29.553264604811, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI33469958, Length=308, Percent_Identity=28.8961038961039, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=47.6190476190476, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1790207, Length=365, Percent_Identity=36.4383561643836, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI71991565, Length=397, Percent_Identity=39.2947103274559, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17537387, Length=384, Percent_Identity=35.15625, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17508781, Length=315, Percent_Identity=31.4285714285714, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=39.6774193548387, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=326, Percent_Identity=39.5705521472393, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6319788, Length=299, Percent_Identity=25.4180602006689, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355833, Length=383, Percent_Identity=40.4699738903394, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24645328, Length=287, Percent_Identity=40.418118466899, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42804; Mature: 42804

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEIKDVQEARIRLLGVAHRTLTAYSATFSRLAGAEVYFKYENLQKTGSFKLRGAYNKVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECHHHHH
SLPVKERERGVVAASAGNHAQGVAFASFSAGIPATIVMPEGAPLAKIQATQSYGAKVILH
CCCCCHHHCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCEEEEECCCCCCEEEEE
GVSYDDAFLKAKEIMEKEGATFVHAFDDPKVIAGQGTIALEMLEDVPELDMLVAPVGGGG
ECCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCEEHHHHHCCCCCCEEEEECCCCH
LIAGLAVAAKAIKPHLKVIGVQAKGAPSAYASLKERRKVTLASVSTIADGIAVKTPGELT
HHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHEEHHHHHHHHHCCCEECCCHHHH
SKIIFDLVDDIVLVDDEEIAQAILMMLERGKVMLEGAGAVGVAALLAQKIPVRGHKVGVV
HHHHHHHHCCEEEECCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCEEEEE
LSGGNIDVHTISIIIERGLVKSGRYVRIKTILDDKPGALQKLLELIAREKANIIFINHDR
EECCCEEEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCC
IAPHVPIKQAEVELALETRDLSHIEKILAVLREAGYQILQN
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVEIKDVQEARIRLLGVAHRTLTAYSATFSRLAGAEVYFKYENLQKTGSFKLRGAYNKVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECHHHHH
SLPVKERERGVVAASAGNHAQGVAFASFSAGIPATIVMPEGAPLAKIQATQSYGAKVILH
CCCCCHHHCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCEEEEECCCCCCEEEEE
GVSYDDAFLKAKEIMEKEGATFVHAFDDPKVIAGQGTIALEMLEDVPELDMLVAPVGGGG
ECCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCEEHHHHHCCCCCCEEEEECCCCH
LIAGLAVAAKAIKPHLKVIGVQAKGAPSAYASLKERRKVTLASVSTIADGIAVKTPGELT
HHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHEEHHHHHHHHHCCCEECCCHHHH
SKIIFDLVDDIVLVDDEEIAQAILMMLERGKVMLEGAGAVGVAALLAQKIPVRGHKVGVV
HHHHHHHHCCEEEECCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCEEEEE
LSGGNIDVHTISIIIERGLVKSGRYVRIKTILDDKPGALQKLLELIAREKANIIFINHDR
EECCCEEEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCC
IAPHVPIKQAEVELALETRDLSHIEKILAVLREAGYQILQN
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]