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The map label for this gene is tlpA [H]

Identifier: 78043239

GI number: 78043239

Start: 183770

End: 184876

Strand: Direct

Name: tlpA [H]

Synonym: CHY_0217

Alternate gene names: 78043239

Gene position: 183770-184876 (Clockwise)

Preceding gene: 78042845

Following gene: 78043165

Centisome position: 7.65

GC content: 45.44

Gene sequence:

>1107_bases
ATGAAGATGAAAATAAATAACTGGTACCAGTGGTTAAACGTACTATTAGGTCTTACCGGGATTGGGGCGGGAGTTATTAC
CGAAAATATTTTGGCACTGGCCCTTGGCATCGGGTTAGGCCTAACTACCATAGCCAATTATTTCTTATATTTAAAGGAAA
ATGAGGAAAGGAAAAGGCTTTTACAATTGGGAGAAGCGGTAAAAAACCGGAACCTTAAAGAACTTGTGGAGTATACACCG
CCACCAAAAGGCAGCTTTAAAGAACTGGGAGAAACCTTTAAGTTTCTCGGAAAGGTGGTTTATAACTCCATAAAATTTGC
GGGAAAAGATGCCAAAACTCAAGGGGAAATCATTGAAAGCCTGACCGCTGCTCTGGAACAGGTAGCCACAGGAACCCAGC
ATCAGGTAGGGCAAATTCAAAATTTAACCCTTTCTTTAGAAAAGCTCGCCCAGGAAATTAACGAAGTAGCCAGGTTTGCT
CTTGCGACGGAAAACCTGGCGCGAAAAACGCGCGAGCTTACCCAAAATGGAGTAGTACAAAGTGAAACTGCCCAACGGGA
AATGGAGAGCATCAAGCAGAGCATTAACGAGTTAGAGAAAAATTCAGCCAACATTGCCGCAATCTTAGAGGTGATAAACG
AAATAGCCGACCAAACTTCACTTTTGGCGTTAAATGCGGCGATTGAAGCTGCCCGGGCCGGAGAAGCCGGGCGCGGTTTT
GCGGTAGTTGCCGAGGAGGTGCGCAAACTTGCCGATAAATCCCGGGAGTCTGTGAAAAAAATTGAGGAAATTGTGAAAGA
TGTCCAGTTCAAAACCAGTACTGCGGTTACCATGACGCAAAACGGAGTAATGGCCCTTGCAAGACTGAGTCAAGCTTTTA
GTGAGATTAATGCTAATGTTGAAGAGGTAGTGAGCCATATGGCAACGGTTTCCGAAAAAACCGGGATTCAAGCTGCGGCC
AGCGAGGAAGTGTCAGGGGCGGCTCAAGCTATTGCTGCAGTTATTGAAGAGATTTCCGCAAGTACTCAGGAACTAGCGGC
TACCTCGCAAAAACTTAAGGAAATAACCGACGGTTTAAAGAAACGGGTTGCCAGTTACCAGCTTTAA

Upstream 100 bases:

>100_bases
TAGGGATGGTATCCAAACCCTAAAGGTGTTTTTTTAATCTACAATTTACAACGATTAAGAAGAGTTGGTAAAATAAAAGA
AACAAAAATGAGGTGGAAAG

Downstream 100 bases:

>100_bases
AAAGCCATGGCCTTAGGCCATGGCTTTTAAGGTTGATATCCCCCAAAGGTGTGGGAGCTTAGATAGATACTATCAATAAG
TGATGCGGTTTTGGGCATAT

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKMKINNWYQWLNVLLGLTGIGAGVITENILALALGIGLGLTTIANYFLYLKENEERKRLLQLGEAVKNRNLKELVEYTP
PPKGSFKELGETFKFLGKVVYNSIKFAGKDAKTQGEIIESLTAALEQVATGTQHQVGQIQNLTLSLEKLAQEINEVARFA
LATENLARKTRELTQNGVVQSETAQREMESIKQSINELEKNSANIAAILEVINEIADQTSLLALNAAIEAARAGEAGRGF
AVVAEEVRKLADKSRESVKKIEEIVKDVQFKTSTAVTMTQNGVMALARLSQAFSEINANVEEVVSHMATVSEKTGIQAAA
SEEVSGAAQAIAAVIEEISASTQELAATSQKLKEITDGLKKRVASYQL

Sequences:

>Translated_368_residues
MKMKINNWYQWLNVLLGLTGIGAGVITENILALALGIGLGLTTIANYFLYLKENEERKRLLQLGEAVKNRNLKELVEYTP
PPKGSFKELGETFKFLGKVVYNSIKFAGKDAKTQGEIIESLTAALEQVATGTQHQVGQIQNLTLSLEKLAQEINEVARFA
LATENLARKTRELTQNGVVQSETAQREMESIKQSINELEKNSANIAAILEVINEIADQTSLLALNAAIEAARAGEAGRGF
AVVAEEVRKLADKSRESVKKIEEIVKDVQFKTSTAVTMTQNGVMALARLSQAFSEINANVEEVVSHMATVSEKTGIQAAA
SEEVSGAAQAIAAVIEEISASTQELAATSQKLKEITDGLKKRVASYQL
>Mature_368_residues
MKMKINNWYQWLNVLLGLTGIGAGVITENILALALGIGLGLTTIANYFLYLKENEERKRLLQLGEAVKNRNLKELVEYTP
PPKGSFKELGETFKFLGKVVYNSIKFAGKDAKTQGEIIESLTAALEQVATGTQHQVGQIQNLTLSLEKLAQEINEVARFA
LATENLARKTRELTQNGVVQSETAQREMESIKQSINELEKNSANIAAILEVINEIADQTSLLALNAAIEAARAGEAGRGF
AVVAEEVRKLADKSRESVKKIEEIVKDVQFKTSTAVTMTQNGVMALARLSQAFSEINANVEEVVSHMATVSEKTGIQAAA
SEEVSGAAQAIAAVIEEISASTQELAATSQKLKEITDGLKKRVASYQL

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=221, Percent_Identity=33.0316742081448, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788194, Length=258, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788195, Length=240, Percent_Identity=29.5833333333333, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787690, Length=247, Percent_Identity=30.3643724696356, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789453, Length=235, Percent_Identity=29.3617021276596, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 39950; Mature: 39950

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKINNWYQWLNVLLGLTGIGAGVITENILALALGIGLGLTTIANYFLYLKENEERKRL
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LQLGEAVKNRNLKELVEYTPPPKGSFKELGETFKFLGKVVYNSIKFAGKDAKTQGEIIES
HHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LTAALEQVATGTQHQVGQIQNLTLSLEKLAQEINEVARFALATENLARKTRELTQNGVVQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SETAQREMESIKQSINELEKNSANIAAILEVINEIADQTSLLALNAAIEAARAGEAGRGF
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AVVAEEVRKLADKSRESVKKIEEIVKDVQFKTSTAVTMTQNGVMALARLSQAFSEINANV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCH
EEVVSHMATVSEKTGIQAAASEEVSGAAQAIAAVIEEISASTQELAATSQKLKEITDGLK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRVASYQL
HHHHHCCC
>Mature Secondary Structure
MKMKINNWYQWLNVLLGLTGIGAGVITENILALALGIGLGLTTIANYFLYLKENEERKRL
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LQLGEAVKNRNLKELVEYTPPPKGSFKELGETFKFLGKVVYNSIKFAGKDAKTQGEIIES
HHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LTAALEQVATGTQHQVGQIQNLTLSLEKLAQEINEVARFALATENLARKTRELTQNGVVQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SETAQREMESIKQSINELEKNSANIAAILEVINEIADQTSLLALNAAIEAARAGEAGRGF
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AVVAEEVRKLADKSRESVKKIEEIVKDVQFKTSTAVTMTQNGVMALARLSQAFSEINANV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCH
EEVVSHMATVSEKTGIQAAASEEVSGAAQAIAAVIEEISASTQELAATSQKLKEITDGLK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRVASYQL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]