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The map label for this gene is lexA [H]

Identifier: 78043201

GI number: 78043201

Start: 1513491

End: 1514255

Strand: Direct

Name: lexA [H]

Synonym: CHY_1697

Alternate gene names: 78043201

Gene position: 1513491-1514255 (Clockwise)

Preceding gene: 78043477

Following gene: 78043809

Centisome position: 63.02

GC content: 34.77

Gene sequence:

>765_bases
GTGAACTTCGGGCAAAGACTTCGACAATTGCGTACAGAAAGAGATTTAACTCAGGCAGAATTGGCAAAATTGCTTTCAAT
TGGGGAATCCACAATATCTTTTTATGAATCAAATAAACGGCAGCCAGATTTCGATACCCTCATTAAACTCTCAAATTTTT
TTAATGTTTCAATAGATTTTCTTCTTGGTCGCACTGATGAAAGTAATAAATTTATTCAAAACACCAAAACTATCCCTTTA
CTTGGGACAATCCGTGCAGGCATTCCTTTATTAGCTGAAGAAAATTGGATTGAGGAGATTGCATTACCAGCAGGTATAAA
AGCGGATTTTGCCTTACAAGTTGAAGGAGAATCAATGATTTATGCTGGGATCTTCCCTGGAGATATTGCATTTTTCAAAC
AAAGCGAAACAGCAACTAATGGACAAATTGTTGCTGCTGGAGTTGTAGAAGAAACTTGGAAAGCGAATCTTAAATTTTAT
GTGAAAACAAATGGAAAAGCTTTCCTTAGGTCAGCAAACCCAAAATACAAAGATATTGAGATTACACCACAACACAAAAT
AATTGGGATTATGACTGGGCTTGTTCGCCATAATCCCCCTTCAATGACAGATTATATTTCACTAGTAATTACTAAAGACG
AATTTGAAAATTCTTGGATTGAAACAATTGAAACAGCTTTATCTCTTGGAATGTCACCTATTCATGTAAAACAATTAATT
GAGATACAAGCTACTCTTTCAAAAATGATCAAACCCAATGAGTAA

Upstream 100 bases:

>100_bases
ATATTGTCAAGTTTTATTTTTGAATTTGCAAAGAAAATTTTTTTATCTTATCACTTTGCTATTTGCAATGTTATAATTTT
GGTAAATAGAGGTGATTCTG

Downstream 100 bases:

>100_bases
ATTTTAAAGGAGGTTTTTTTATTATGAGTTTTAAAATGGATCAACCGGAAAAGTTTCCTTGGTTTAGAAAAATTCCCGGT
TTTAGAAGTGGTAAACCTTT

Product: putative prophage LambdaCh01, repressor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNFGQRLRQLRTERDLTQAELAKLLSIGESTISFYESNKRQPDFDTLIKLSNFFNVSIDFLLGRTDESNKFIQNTKTIPL
LGTIRAGIPLLAEENWIEEIALPAGIKADFALQVEGESMIYAGIFPGDIAFFKQSETATNGQIVAAGVVEETWKANLKFY
VKTNGKAFLRSANPKYKDIEITPQHKIIGIMTGLVRHNPPSMTDYISLVITKDEFENSWIETIETALSLGMSPIHVKQLI
EIQATLSKMIKPNE

Sequences:

>Translated_254_residues
MNFGQRLRQLRTERDLTQAELAKLLSIGESTISFYESNKRQPDFDTLIKLSNFFNVSIDFLLGRTDESNKFIQNTKTIPL
LGTIRAGIPLLAEENWIEEIALPAGIKADFALQVEGESMIYAGIFPGDIAFFKQSETATNGQIVAAGVVEETWKANLKFY
VKTNGKAFLRSANPKYKDIEITPQHKIIGIMTGLVRHNPPSMTDYISLVITKDEFENSWIETIETALSLGMSPIHVKQLI
EIQATLSKMIKPNE
>Mature_254_residues
MNFGQRLRQLRTERDLTQAELAKLLSIGESTISFYESNKRQPDFDTLIKLSNFFNVSIDFLLGRTDESNKFIQNTKTIPL
LGTIRAGIPLLAEENWIEEIALPAGIKADFALQVEGESMIYAGIFPGDIAFFKQSETATNGQIVAAGVVEETWKANLKFY
VKTNGKAFLRSANPKYKDIEITPQHKIIGIMTGLVRHNPPSMTDYISLVITKDEFENSWIETIETALSLGMSPIHVKQLI
EIQATLSKMIKPNE

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 28528; Mature: 28528

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFGQRLRQLRTERDLTQAELAKLLSIGESTISFYESNKRQPDFDTLIKLSNFFNVSIDF
CCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEE
LLGRTDESNKFIQNTKTIPLLGTIRAGIPLLAEENWIEEIALPAGIKADFALQVEGESMI
EEECCCCCCHHHHCCCCCEEEEEHHCCCCEEECCCHHHHHCCCCCCCCCEEEEECCCEEE
YAGIFPGDIAFFKQSETATNGQIVAAGVVEETWKANLKFYVKTNGKAFLRSANPKYKDIE
EEECCCCCEEEEECCCCCCCCEEEEECHHHHHHCCCEEEEEEECCEEEEECCCCCCCEEE
ITPQHKIIGIMTGLVRHNPPSMTDYISLVITKDEFENSWIETIETALSLGMSPIHVKQLI
ECCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHH
EIQATLSKMIKPNE
HHHHHHHHHCCCCC
>Mature Secondary Structure
MNFGQRLRQLRTERDLTQAELAKLLSIGESTISFYESNKRQPDFDTLIKLSNFFNVSIDF
CCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEE
LLGRTDESNKFIQNTKTIPLLGTIRAGIPLLAEENWIEEIALPAGIKADFALQVEGESMI
EEECCCCCCHHHHCCCCCEEEEEHHCCCCEEECCCHHHHHCCCCCCCCCEEEEECCCEEE
YAGIFPGDIAFFKQSETATNGQIVAAGVVEETWKANLKFYVKTNGKAFLRSANPKYKDIE
EEECCCCCEEEEECCCCCCCCEEEEECHHHHHHCCCEEEEEEECCEEEEECCCCCCCEEE
ITPQHKIIGIMTGLVRHNPPSMTDYISLVITKDEFENSWIETIETALSLGMSPIHVKQLI
ECCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHH
EIQATLSKMIKPNE
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA