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The map label for this gene is aroE

Identifier: 78043133

GI number: 78043133

Start: 537271

End: 538113

Strand: Direct

Name: aroE

Synonym: CHY_0623

Alternate gene names: 78043133

Gene position: 537271-538113 (Clockwise)

Preceding gene: 78043911

Following gene: 78044224

Centisome position: 22.37

GC content: 44.6

Gene sequence:

>843_bases
ATGCGGATAAACGGTGAAACCAAACTAACGGGGATAATCGGTTATCCTTTAAAACATACCCTTTCCCCTCAGATGCATAA
TGAAGCTTTTAAAGCCCTAAATTTAAATTTCCTGTACCTGCCCCTGGAAGTTGCTGAAGAAAGCTTGCCCCAGGCCATCT
ATGGCCTAAAAGCTTTTAACTTTCGGGGGATTAACGTAACCATTCCTTATAAAGAAAAGGTTTTTCCTTTTTTAGATGAA
GTAGCAACGGAAGCAAAAACCATTGGTGCGGTAAATACCATCGTCCATGACCGGGGTAGGCTTATTGGTTACAATACCGA
TGCCCCCGGCTTTTTATTAAGTTTAAAAGAAAACGACGTTGAAGTTACCGGGAAAAAAGTTTTGCTCTTAGGAGCGGGGG
GAGCGGCACGGGCGGTAGCGTATGCGCTTTTAACCGCCGGAGCTGAACTTATCATTGCTAACCGCACCATCGATAAGGCA
AAGGAATTAGCTAAAGACTTCCAGGGAGTCGGGAAAATATCCGAAATTCTTGAACTTGGCGATAAACCCATTTCCCTTGC
GCCTTATCATATGGCGGTTAATACTTTACCCCTGGGAATGCATCCTTATGAAAACCAGATGCCGGCGGTGGATTTTACCG
GCGTTACTTCCGATTTTGTGGCTTACGACCTTATTTATAACCCTGCCGAAACTAAATTCCTGAAAGCTTCTAAAGAAAAA
GGTGCCAGGACAATAAACGGTCTTTCCATGCTGCTCTGGCAGGGTGTTCTGGCTTTTGAAAAATGGACCGGGGTTAGCCC
GCCGGTTAAGGTGATGAAAAAAGCTATCGGCCTTTCTTGTTAA

Upstream 100 bases:

>100_bases
ATCGGAACGAAAATTAACAGGTTTATCGAAAGTTACCTTTTAAAGCGACTTTTACAAAAGGGTCTGAAAATATACGGACC
TCAGGGGGGATTAAATGGCC

Downstream 100 bases:

>100_bases
AGAGCCGGGAATCAAGTAAAATAGAGGTAAATTTTACTGATGGGGGTTGTGCGATGTTTCGGTATTTAACTTCGGGGGAA
TCCCACGGTGAAGGATTATA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MRINGETKLTGIIGYPLKHTLSPQMHNEAFKALNLNFLYLPLEVAEESLPQAIYGLKAFNFRGINVTIPYKEKVFPFLDE
VATEAKTIGAVNTIVHDRGRLIGYNTDAPGFLLSLKENDVEVTGKKVLLLGAGGAARAVAYALLTAGAELIIANRTIDKA
KELAKDFQGVGKISEILELGDKPISLAPYHMAVNTLPLGMHPYENQMPAVDFTGVTSDFVAYDLIYNPAETKFLKASKEK
GARTINGLSMLLWQGVLAFEKWTGVSPPVKVMKKAIGLSC

Sequences:

>Translated_280_residues
MRINGETKLTGIIGYPLKHTLSPQMHNEAFKALNLNFLYLPLEVAEESLPQAIYGLKAFNFRGINVTIPYKEKVFPFLDE
VATEAKTIGAVNTIVHDRGRLIGYNTDAPGFLLSLKENDVEVTGKKVLLLGAGGAARAVAYALLTAGAELIIANRTIDKA
KELAKDFQGVGKISEILELGDKPISLAPYHMAVNTLPLGMHPYENQMPAVDFTGVTSDFVAYDLIYNPAETKFLKASKEK
GARTINGLSMLLWQGVLAFEKWTGVSPPVKVMKKAIGLSC
>Mature_280_residues
MRINGETKLTGIIGYPLKHTLSPQMHNEAFKALNLNFLYLPLEVAEESLPQAIYGLKAFNFRGINVTIPYKEKVFPFLDE
VATEAKTIGAVNTIVHDRGRLIGYNTDAPGFLLSLKENDVEVTGKKVLLLGAGGAARAVAYALLTAGAELIIANRTIDKA
KELAKDFQGVGKISEILELGDKPISLAPYHMAVNTLPLGMHPYENQMPAVDFTGVTSDFVAYDLIYNPAETKFLKASKEK
GARTINGLSMLLWQGVLAFEKWTGVSPPVKVMKKAIGLSC

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=286, Percent_Identity=36.013986013986, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1789675, Length=267, Percent_Identity=31.8352059925094, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320332, Length=281, Percent_Identity=32.0284697508897, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_CARHZ (Q3AEF5)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359479.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q3AEF5
- SMR:   Q3AEF5
- STRING:   Q3AEF5
- GeneID:   3728671
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0623
- NMPDR:   fig|246194.3.peg.366
- TIGR:   CHY_0623
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   NARYLAF
- BioCyc:   CHYD246194:CHY_0623-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30495; Mature: 30495

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRINGETKLTGIIGYPLKHTLSPQMHNEAFKALNLNFLYLPLEVAEESLPQAIYGLKAFN
CCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHEE
FRGINVTIPYKEKVFPFLDEVATEAKTIGAVNTIVHDRGRLIGYNTDAPGFLLSLKENDV
EECEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCE
EVTGKKVLLLGAGGAARAVAYALLTAGAELIIANRTIDKAKELAKDFQGVGKISEILELG
EECCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
DKPISLAPYHMAVNTLPLGMHPYENQMPAVDFTGVTSDFVAYDLIYNPAETKFLKASKEK
CCCCEECCCEEEEECEECCCCCCCCCCCCEEECCCCHHHHHHHEEECCCHHHHHHHHHHC
GARTINGLSMLLWQGVLAFEKWTGVSPPVKVMKKAIGLSC
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRINGETKLTGIIGYPLKHTLSPQMHNEAFKALNLNFLYLPLEVAEESLPQAIYGLKAFN
CCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHEE
FRGINVTIPYKEKVFPFLDEVATEAKTIGAVNTIVHDRGRLIGYNTDAPGFLLSLKENDV
EECEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCE
EVTGKKVLLLGAGGAARAVAYALLTAGAELIIANRTIDKAKELAKDFQGVGKISEILELG
EECCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
DKPISLAPYHMAVNTLPLGMHPYENQMPAVDFTGVTSDFVAYDLIYNPAETKFLKASKEK
CCCCEECCCEEEEECEECCCCCCCCCCCCEEECCCCHHHHHHHEEECCCHHHHHHHHHHC
GARTINGLSMLLWQGVLAFEKWTGVSPPVKVMKKAIGLSC
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA