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The map label for this gene is bcd1 [H]

Identifier: 78042819

GI number: 78042819

Start: 1179972

End: 1181117

Strand: Direct

Name: bcd1 [H]

Synonym: CHY_1323

Alternate gene names: 78042819

Gene position: 1179972-1181117 (Clockwise)

Preceding gene: 78044351

Following gene: 78043112

Centisome position: 49.13

GC content: 42.32

Gene sequence:

>1146_bases
ATGGATTTTAGGTTATCTGAAGAGCACGAATTATTAAGGCAAACGGTAAGAGAGTTTGCTGAAAAAGAAGTTGCCCCATC
TGCAGCCGCAAGAGACGAAGAGGAAAGATTTGACCGGGAAATCTTTAAGAAAATGGCCGAATTAGGGTTAACGGGCATTC
CCTGGCCCGAAGAATATGGCGGGGCAGGAATGGATTATCTTGCCTATGTTATCGCTGTGGAAGAACTTTCCCGGGTTTGT
GCTTCTACCGGTGTTACATTATCCGCTCACGTTTCGTTGGGAAGTTTCCCAATTTATAAATATGGGACGGAAGAACAAAA
GCAAAAATACCTAAAACCGCTGGCTTTGGGCGAAAAAATGGGTGCTTTCGGGTTGACCGAGCCTTCAGCGGGCACAGATG
CCGGTTCATTAAAGACAACAGCGGTAAAAGATGGAGATTATTATGTATTAAACGGATCCAAAATTTTCATAACCAATGGG
GGAGAAGCAGAAATATATGTAGTTTTTGCAACTGTTGATAAAAATAAAAGACACAAAGGAATTTCTGCTTTTATTGTCGA
GAAGGGAACACCTGGGTTTAATTTTGGTAAAAAAGAGAAGAAAATGGGCATTCGTTCTTCCCCGACAGTTGAGTTAATTT
TTGAAAATTGCCGGATTCCAAAGGAAAATTTACTTGGTGAAGAAGGTCAGGGATTTAAAATTGCTTTATCTACCTTAGAT
GGCGGACGCATTGGTATTGCTGCTCAGGCGGTAGGTATAGCCCAAGGAGCTTACGAAGCTGCAGTGAAATATGCCAAGGA
AAGAACCCAGTTTGGCAAACCCATAGCTGAATTTCAAGGAGTAAGTTTTGTTTTAGCGGATATGGCGACTAAAATCCAGG
CGGCAAGGTTGCTGGTTTATCATGCTGCCTGGCTTGAATCAAACAATCTGCCCTATGGCAAAGCTGCATCAATGGCTAAA
CTTTTTGCTGCAGAAACGGCTATGGAAGTTACCACGAAGGCGGTTCAAATTTTTGGAGGCTATGGCTATACCCGTGAATA
TCCGGTAGAACGGATGATGAGAGATGCTAAAATCACCGAAATTTATGAAGGTACCAGTGAAGTGCAAAGAATGGTGATTT
CATCGTATATCCTCAAGGAATTTTAG

Upstream 100 bases:

>100_bases
GACACAGGTTTTCAATTATGCTTTCAGGAAAATTATGCATATATGAATAAAATTTTCTTTAGTTTTATCTATAAAAAAAA
TAAAAAAAGGAGGAGTTCAT

Downstream 100 bases:

>100_bases
TGCTTTAAAGGGTGAGGTAAATGTTATTAAACTATCATGCCGAATATAGAAAAAAATTAACAACTGTTGAGCAAGCACTG
GAAGTAATTACGAATAATTG

Product: butyryl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDFRLSEEHELLRQTVREFAEKEVAPSAAARDEEERFDREIFKKMAELGLTGIPWPEEYGGAGMDYLAYVIAVEELSRVC
ASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKMGAFGLTEPSAGTDAGSLKTTAVKDGDYYVLNGSKIFITNG
GEAEIYVVFATVDKNKRHKGISAFIVEKGTPGFNFGKKEKKMGIRSSPTVELIFENCRIPKENLLGEEGQGFKIALSTLD
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVYHAAWLESNNLPYGKAASMAK
LFAAETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITEIYEGTSEVQRMVISSYILKEF

Sequences:

>Translated_381_residues
MDFRLSEEHELLRQTVREFAEKEVAPSAAARDEEERFDREIFKKMAELGLTGIPWPEEYGGAGMDYLAYVIAVEELSRVC
ASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKMGAFGLTEPSAGTDAGSLKTTAVKDGDYYVLNGSKIFITNG
GEAEIYVVFATVDKNKRHKGISAFIVEKGTPGFNFGKKEKKMGIRSSPTVELIFENCRIPKENLLGEEGQGFKIALSTLD
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVYHAAWLESNNLPYGKAASMAK
LFAAETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITEIYEGTSEVQRMVISSYILKEF
>Mature_381_residues
MDFRLSEEHELLRQTVREFAEKEVAPSAAARDEEERFDREIFKKMAELGLTGIPWPEEYGGAGMDYLAYVIAVEELSRVC
ASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKMGAFGLTEPSAGTDAGSLKTTAVKDGDYYVLNGSKIFITNG
GEAEIYVVFATVDKNKRHKGISAFIVEKGTPGFNFGKKEKKMGIRSSPTVELIFENCRIPKENLLGEEGQGFKIALSTLD
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVYHAAWLESNNLPYGKAASMAK
LFAAETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITEIYEGTSEVQRMVISSYILKEF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=54.9071618037135, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=44.2970822281167, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=42.7055702917772, Blast_Score=311, Evalue=4e-85,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=40.9448818897638, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=41.8666666666667, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=41.8666666666667, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI226958414, Length=351, Percent_Identity=41.025641025641, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=43.3048433048433, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI76496475, Length=375, Percent_Identity=40, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI4557235, Length=375, Percent_Identity=40, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=35.0132625994695, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=33.42175066313, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=33.8842975206612, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI48976061, Length=346, Percent_Identity=32.6589595375723, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI211971008, Length=346, Percent_Identity=32.6589595375723, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI38505218, Length=351, Percent_Identity=27.6353276353276, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI218563752, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=33.7662337662338, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=31.151832460733, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI87082384, Length=283, Percent_Identity=25.7950530035336, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081702, Length=297, Percent_Identity=27.9461279461279, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=43.6507936507937, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=41.3793103448276, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=42.5196850393701, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=45.1948051948052, Blast_Score=314, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=44.9612403100775, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=40.1595744680851, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=40.9448818897638, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=48.5611510791367, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=40.1685393258427, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=33.6870026525199, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=42.9824561403509, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71985192, Length=290, Percent_Identity=41.0344827586207, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=35.6363636363636, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17505929, Length=370, Percent_Identity=28.1081081081081, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=370, Percent_Identity=28.3783783783784, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=33.469387755102, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562446, Length=334, Percent_Identity=29.3413173652695, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=183, Percent_Identity=31.6939890710383, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86563383, Length=267, Percent_Identity=27.3408239700375, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=267, Percent_Identity=27.3408239700375, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=52.5198938992042, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=47.8835978835979, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=42.9708222811671, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=43.8829787234042, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=39.84375, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI281363737, Length=389, Percent_Identity=38.560411311054, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=31.758530183727, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI281365206, Length=411, Percent_Identity=23.8442822384428, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585193, Length=411, Percent_Identity=23.8442822384428, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585195, Length=411, Percent_Identity=23.8442822384428, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585191, Length=411, Percent_Identity=23.8442822384428, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550141, Length=327, Percent_Identity=25.6880733944954, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221473076, Length=327, Percent_Identity=25.6880733944954, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41911; Mature: 41911

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRLSEEHELLRQTVREFAEKEVAPSAAARDEEERFDREIFKKMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GAGMDYLAYVIAVEELSRVCASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKM
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHC
GAFGLTEPSAGTDAGSLKTTAVKDGDYYVLNGSKIFITNGGEAEIYVVFATVDKNKRHKG
CCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCEEEEECCCCEEEEEEEEEECCCCCCCC
ISAFIVEKGTPGFNFGKKEKKMGIRSSPTVELIFENCRIPKENLLGEEGQGFKIALSTLD
CEEEEEECCCCCCCCCCHHHHCCCCCCCCCEEEEHHCCCCHHHCCCCCCCCEEEEEEECC
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
HAAWLESNNLPYGKAASMAKLFAAETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQRMVISSYILKEF
HHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFRLSEEHELLRQTVREFAEKEVAPSAAARDEEERFDREIFKKMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GAGMDYLAYVIAVEELSRVCASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKM
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHC
GAFGLTEPSAGTDAGSLKTTAVKDGDYYVLNGSKIFITNGGEAEIYVVFATVDKNKRHKG
CCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCEEEEECCCCEEEEEEEEEECCCCCCCC
ISAFIVEKGTPGFNFGKKEKKMGIRSSPTVELIFENCRIPKENLLGEEGQGFKIALSTLD
CEEEEEECCCCCCCCCCHHHHCCCCCCCCCEEEEHHCCCCHHHCCCCCCCCEEEEEEECC
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
HAAWLESNNLPYGKAASMAKLFAAETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQRMVISSYILKEF
HHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]