Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 77761149

GI number: 77761149

Start: 1610522

End: 1611580

Strand: Reverse

Name: purM [H]

Synonym: XC_1324

Alternate gene names: 77761149

Gene position: 1611580-1610522 (Counterclockwise)

Preceding gene: 66767655

Following gene: 66767650

Centisome position: 31.3

GC content: 66.95

Gene sequence:

>1059_bases
GTGACCAGCCCAACGCCTTCCAATCCCTCGCCCATGACCTACCGTGACGCGGGCGTCGACATCGATGCCGGCAATGCGTT
GGTCGAACGCATCAAACCCCTGGTCAAGCGCAGCTTTCGACCGGAGGTGATGGGCGGCCTGGGCGGCTTCGGTGCCTTGT
TCGACCTGTCCGGCAAGTACAAGGAGCCGGTGCTGGTCTCCGGCACCGACGGGGTGGGCACCAAGCTCAAACTCGCCCAG
CAGCTCGGCCGCCACGACACCATCGGCATCGACCTGGTCGGCATGTGCGTCAACGACGTGCTGGTGCAAGGCGCCGAACC
ACTGTTCTTTCTGGACTACTTCGCCACCGGCAAGCTGGATATCGACACCGCCGCGGCGGTGGTCGGCGGCATCGCGCGCG
GCTGCGAGCTCTCCGGCTGCGCGCTGATTGGTGGCGAAACCGCGGAGATGCCCGACATGTACCCGCCGGGCGAATACGAC
CTGGCCGGCTTCACCGTTGGCGCGGTGGAAAAATCGCAGCTGCTGGACGGCGCGCAGGTGCGCGAGGGTGACGTGCTGAT
CGGCATCGCCTCCTCCGGACCGCATTCCAATGGGTATTCGCTGATCCGCAAGATCTACGAGCGTGCCGGCTCGCCGGCCG
ATCTGGTGCTGGACGACGGCGTGGCGCTGATCGATGCGCTGATGGCGCCGACCGCGCTGTACGTCAAGCCGATCCTGGCG
CTGCTCAAGTCGCACGGCGAGGCGATCCACGCCATGGCGCATGTCACCGGTGGCGGGCTGACCGAGAACATCATCCGGGT
GATCCCGGACGGCCTGGGCCTGGACATCGATGCCACGGCATGGATCTTGCCGCCGGTGTTCGCCTGGCTGCAGCGCGAAG
GCGCGGTGGCCGATGCCGAAATGTGGCGCACCTTCAATTGCGGCATCGGCTTCGTGCTGGTCGCCGCACCAGCGCAGGCC
GCCGCGCTGGAACAGGCGCTGGACGCGCAGTCGCTGGCGCATTGGCGCATTGGCCAGGTGGTGACGGCACAGGGCGACGA
ACGCGTCCGGATTGGTTGA

Upstream 100 bases:

>100_bases
CCATGACGTAAGCGTATCCGGGTGAATTGTTGCCCGAATGGGACGCTAGCGCCAACGTGGCTGTTAAAATCGCCGCCTTT
ACCGCCGAGCCACCCCACCC

Downstream 100 bases:

>100_bases
CCCAAGGAGCACCCGCATGGAAGCCGCGCCCGTTTACGTCTCTACAACTGCCACCGCCGAGGATCTGCAGCAGCTGAAGT
TGCTGTCGATCTTCCATTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTSPTPSNPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKYKEPVLVSGTDGVGTKLKLAQ
QLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLDIDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYD
LAGFTVGAVEKSQLLDGAQVREGDVLIGIASSGPHSNGYSLIRKIYERAGSPADLVLDDGVALIDALMAPTALYVKPILA
LLKSHGEAIHAMAHVTGGGLTENIIRVIPDGLGLDIDATAWILPPVFAWLQREGAVADAEMWRTFNCGIGFVLVAAPAQA
AALEQALDAQSLAHWRIGQVVTAQGDERVRIG

Sequences:

>Translated_352_residues
MTSPTPSNPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKYKEPVLVSGTDGVGTKLKLAQ
QLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLDIDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYD
LAGFTVGAVEKSQLLDGAQVREGDVLIGIASSGPHSNGYSLIRKIYERAGSPADLVLDDGVALIDALMAPTALYVKPILA
LLKSHGEAIHAMAHVTGGGLTENIIRVIPDGLGLDIDATAWILPPVFAWLQREGAVADAEMWRTFNCGIGFVLVAAPAQA
AALEQALDAQSLAHWRIGQVVTAQGDERVRIG
>Mature_351_residues
TSPTPSNPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKYKEPVLVSGTDGVGTKLKLAQQ
LGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLDIDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYDL
AGFTVGAVEKSQLLDGAQVREGDVLIGIASSGPHSNGYSLIRKIYERAGSPADLVLDDGVALIDALMAPTALYVKPILAL
LKSHGEAIHAMAHVTGGGLTENIIRVIPDGLGLDIDATAWILPPVFAWLQREGAVADAEMWRTFNCGIGFVLVAAPAQAA
ALEQALDAQSLAHWRIGQVVTAQGDERVRIG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=351, Percent_Identity=53.8461538461538, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=351, Percent_Identity=53.8461538461538, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=351, Percent_Identity=53.8461538461538, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=59.5375722543353, Blast_Score=407, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567511, Length=355, Percent_Identity=41.1267605633803, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=46.9387755102041, Blast_Score=305, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24582400, Length=268, Percent_Identity=46.2686567164179, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36876; Mature: 36745

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPTPSNPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKY
CCCCCCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHEECCCCC
KEPVLVSGTDGVGTKLKLAQQLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLD
CCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
IDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYDLAGFTVGAVEKSQLLDGAQV
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCE
REGDVLIGIASSGPHSNGYSLIRKIYERAGSPADLVLDDGVALIDALMAPTALYVKPILA
ECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHH
LLKSHGEAIHAMAHVTGGGLTENIIRVIPDGLGLDIDATAWILPPVFAWLQREGAVADAE
HHHHCCHHEEHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
MWRTFNCGIGFVLVAAPAQAAALEQALDAQSLAHWRIGQVVTAQGDERVRIG
HHEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEECC
>Mature Secondary Structure 
TSPTPSNPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKY
CCCCCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHEECCCCC
KEPVLVSGTDGVGTKLKLAQQLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLD
CCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
IDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYDLAGFTVGAVEKSQLLDGAQV
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCE
REGDVLIGIASSGPHSNGYSLIRKIYERAGSPADLVLDDGVALIDALMAPTALYVKPILA
ECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHH
LLKSHGEAIHAMAHVTGGGLTENIIRVIPDGLGLDIDATAWILPPVFAWLQREGAVADAE
HHHHCCHHEEHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
MWRTFNCGIGFVLVAAPAQAAALEQALDAQSLAHWRIGQVVTAQGDERVRIG
HHEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]