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The map label for this gene is speA

Identifier: 77748748

GI number: 77748748

Start: 4613362

End: 4615248

Strand: Reverse

Name: speA

Synonym: XAC3923

Alternate gene names: 77748748

Gene position: 4615248-4613362 (Counterclockwise)

Preceding gene: 21244644

Following gene: 21244641

Centisome position: 89.17

GC content: 64.49

Gene sequence:

>1887_bases
ATGAGCGATTGGTCCCTCGACCAAGCCCGCAAGACCTATTCGATCCCGCACTGGGCCGACGGGTATTTCGATGTGAACGC
TGCCGGACACGTGGTGGTCACCCCGACCGCCGATGGTCCGGCGGTGTCGCTGCCCGAGGTGGTCGATGCCGCGCGCGCTG
CCGGTGCCAAGCTGCCGCTACTGGTGCGCTTCCCGGACATCCTGGGCCAACGCCTGGGCAAGCTGCAGGCAGCGTTTGCG
CAGGCGCAGTCGGAGTGGGATTACGCCGGCGGCTATACGGCCGTGTATCCGATCAAGGTCAACCAGCATCGCGGCGTGGC
CGGCACCCTGGCCAGCCACCACGGTGAGGGCTTCGGGCTGGAAGCGGGCAGCAAACCGGAACTGATGGCGGTGCTGGCGC
TGTCGCGTCCGGGCGGGCTGATCGTGTGCAACGGCTACAAGGACCGCGAATACATCCGCCTGGCGCTGATCGGCCGCAAA
CTCGGCCTGCAGACCTTCATCGTCATCGAAAAGCCTTCCGAACTGACCCTGGTGCTGGAAGAAGCACGCGCGCTGGACGT
CAAGCCCGGCCTGGGCGTGCGCATGCGCCTGGCCTCGCTGGGTGCGGGCAAGTGGCAGAACAGCGGTGGCGACAAGGCCA
AGTTCGGTCTCTCGCCGCGCCAGGTGCTGGACCTGTGGAAGACGCTGCGCGACACCGAGTACGCCGACAGCCTGAACCTG
CTGCATTTCCACATGGGCTCGCAGATTTCCAATGTGCGCGACATCGCCAACGGCATGCGCGAGGCCACGCGCTATTTCGT
GGAGCTCTCGCGCCTGGGCGCAAAGATCAGCCATGTCGACGTCGGTGGCGGCCTGGGCATCGATTACGAAGGCACGCGCT
CGCGCAGCTATTGCTCGATCAACTACGGCCTGCATTCGTACGCCAGCAATATCGTGCAGCCGCTGGCCAGCGCCTGCGAA
GAGCATGGCCTGACCCCGCCACGCATCGTCACCGAGTGCGGGCGCGCGATGACGGCGCACCATGCGGTGCTGATCGCCAA
CGTGTCGGAAGTGGAACAGGCGCCGGAAGGCCGCGTGCCGGACGCGCACGACGACGAACCGGCCGCGATCCGCCACCTGC
GCGAGATCCATGACGAGCTCGATGTGCGCCCGGCGGTGGAATTGTTCCAGGAAGCCCAGCATTTCCATGCCGAAGGCCTC
AGCGCCTATGCGCTGGGCCAGATCGACCTGACCCACCGTGCGCGCATCGACGATCTGTTCTACGCCATCGCACATGGCGT
GCGCGCACGTTTGAGCTTCGACGAGAAGAGCCATCGCCCGGTGCTGGATGAGCTCAACGAGCGGCTGGTGGACAAGTACT
TCGTCAATTTCAGCGTGTTCGAGTCGATTCCGGACGTGTGGGCGATCGATCAGGTGTTTCCGATCGTACCGATCGAGCGC
CTGAACGAAGCGCCGCAGCGGCGCGGCATCATCGCCGACATGACCTGCGATTCCGACGGCATGGTCAAGACCTATGTCGA
GAACGAAAGCCTGGACAGCTCGCTACCGCTGCATCGTTTGAATGCCGGTGAGAGCTATCGCATCGGCTTTTTCCTGGTGG
GCGCCTATCAGGAAATCCTGGGCGATATCCATAACCTGTTCGGCGATACCGATGCGGTGGAAGTCGTGGTGGATCGCGAT
GGCTATCGCATCGCCCAGCAGCGCCGCGGCGATACCACCGACGTGATGCTCGACTACGTGGGCTATCAGCTGGACACGCT
GCGTGCCACCTATGCCGAGCGCATTGCTGCCGCACACCTCTCGCCCGAACGGGCGCAGGAACTCAGCGCTGCGCTGGAAG
CTGGGCTGACCGGATACACCTATCTCTCCGACGAGCCGCTGGGCTGA

Upstream 100 bases:

>100_bases
AACCAGGAGAGGGGCGTGAAGTCGGCGCGGATTGTAACGGACCCTGCGCATGCCAGGCGTTACACTTCACGCCCTTTTTT
ATTCCAGCCGAGACAGCGAA

Downstream 100 bases:

>100_bases
TCCGCAGTGCGCTGGGGCAACGCCGCAGCGCTGGCTGTGCAACGACATGGCAACCTGCCACGCGTTCCCGCCGCAAACAC
CGCGCAGGGACATCACCGGC

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPLLVRFPDILGQRLGKLQAAFA
QAQSEWDYAGGYTAVYPIKVNQHRGVAGTLASHHGEGFGLEAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRK
LGLQTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVLDLWKTLRDTEYADSLNL
LHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSINYGLHSYASNIVQPLASACE
EHGLTPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVPDAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGL
SAYALGQIDLTHRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESIPDVWAIDQVFPIVPIER
LNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHRLNAGESYRIGFFLVGAYQEILGDIHNLFGDTDAVEVVVDRD
GYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAAHLSPERAQELSAALEAGLTGYTYLSDEPLG

Sequences:

>Translated_628_residues
MSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPLLVRFPDILGQRLGKLQAAFA
QAQSEWDYAGGYTAVYPIKVNQHRGVAGTLASHHGEGFGLEAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRK
LGLQTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVLDLWKTLRDTEYADSLNL
LHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSINYGLHSYASNIVQPLASACE
EHGLTPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVPDAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGL
SAYALGQIDLTHRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESIPDVWAIDQVFPIVPIER
LNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHRLNAGESYRIGFFLVGAYQEILGDIHNLFGDTDAVEVVVDRD
GYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAAHLSPERAQELSAALEAGLTGYTYLSDEPLG
>Mature_627_residues
SDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPLLVRFPDILGQRLGKLQAAFAQ
AQSEWDYAGGYTAVYPIKVNQHRGVAGTLASHHGEGFGLEAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRKL
GLQTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVLDLWKTLRDTEYADSLNLL
HFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSINYGLHSYASNIVQPLASACEE
HGLTPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVPDAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGLS
AYALGQIDLTHRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESIPDVWAIDQVFPIVPIERL
NEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHRLNAGESYRIGFFLVGAYQEILGDIHNLFGDTDAVEVVVDRDG
YRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAAHLSPERAQELSAALEAGLTGYTYLSDEPLG

Specific function: Catalyzes the biosynthesis of agmatine from arginine

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily

Homologues:

Organism=Escherichia coli, GI1789307, Length=636, Percent_Identity=48.4276729559748, Blast_Score=595, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_XANAC (Q8PFQ5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644224.2
- ProteinModelPortal:   Q8PFQ5
- GeneID:   1157994
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3923
- NMPDR:   fig|190486.1.peg.3868
- HOGENOM:   HBG321436
- OMA:   TCDSDGE
- ProtClustDB:   PRK05354
- BioCyc:   XAXO190486:XAC3923-MONOMER
- BRENDA:   4.1.1.19
- HAMAP:   MF_01417
- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PANTHER:   PTHR11482:SF3
- PIRSF:   PIRSF001336
- PRINTS:   PR01180
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01273

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.19

Molecular weight: Translated: 69092; Mature: 68961

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPL
CCCCCCHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCE
LVRFPDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQHRGVAGTLASHHGEGFGL
EEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCCC
EAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRKLGLQTFIVIEKPSELTLVLE
CCCCCCCEEEEEEECCCCCEEEECCCCCCHHEEEEEHHHHCCCEEEEEEECCCCEEEEEE
EARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVLDLWKTLRDTEYADSLNL
HHHHCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCE
LHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSI
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEE
NYGLHSYASNIVQPLASACEEHGLTPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVP
ECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHCCCCCCC
DAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGLSAYALGQIDLTHRARIDDLF
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHH
YAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESIPDVWAIDQVFPIVPIER
HHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHH
LNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHRLNAGESYRIGFFLVGAYQEIL
HCCCHHHCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHH
GDIHNLFGDTDAVEVVVDRDGYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAAHL
HHHHHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
SPERAQELSAALEAGLTGYTYLSDEPLG
CHHHHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure 
SDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPL
CCCCCHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCE
LVRFPDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQHRGVAGTLASHHGEGFGL
EEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCCC
EAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRKLGLQTFIVIEKPSELTLVLE
CCCCCCCEEEEEEECCCCCEEEECCCCCCHHEEEEEHHHHCCCEEEEEEECCCCEEEEEE
EARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVLDLWKTLRDTEYADSLNL
HHHHCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCE
LHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSI
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEE
NYGLHSYASNIVQPLASACEEHGLTPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVP
ECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHCCCCCCC
DAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGLSAYALGQIDLTHRARIDDLF
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHH
YAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESIPDVWAIDQVFPIVPIER
HHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHH
LNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHRLNAGESYRIGFFLVGAYQEIL
HCCCHHHCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHH
GDIHNLFGDTDAVEVVVDRDGYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAAHL
HHHHHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
SPERAQELSAALEAGLTGYTYLSDEPLG
CHHHHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217