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The map label for this gene is xorIIM [H]

Identifier: 77465763

GI number: 77465763

Start: 885800

End: 887131

Strand: Reverse

Name: xorIIM [H]

Synonym: RSP_3758

Alternate gene names: 77465763

Gene position: 887131-885800 (Counterclockwise)

Preceding gene: 77465764

Following gene: 77465762

Centisome position: 94.07

GC content: 65.47

Gene sequence:

>1332_bases
TTGAGACCTATTGGAATCGACCTGTTCGCCGGCGCAGGAGGCCTGTCGCTCGGCTTCGAGCAGGCGGGCTTCGACGTTGC
CGCTGCCGTCGAGATCGATCCCGTGCACTGCGCCGTGCACAAGTTCAACTTCCCCGACACCGCCGTAATCCCGCGGTCGG
TCGTGGGGCTCACGGCCGAGGAGATCCGCGAATCCGCCGGCATCGGGAACCGCCCCATCGACTGTGTCTTCGGTGGGCCG
CCCTGCCAAGGCTTCTCCTTGATCGGGCACCGCGCCCTGGAGGATCCACGCAACAGCCTGGTGCTCGAGTTCGTACGCCT
GGTGCGGGAGCTCGATGCACGGACCTTCGTCTTCGAGAACGTCAAGGGGCTGACGGTTGGCTCCCATCGGACCTTCCTCA
GCGAGCTCGTCGCCGCATTCGGCATGGCGGGCTACGATGTTCGCTTGCCTTGGAAGGTTCTCGATGCGGCGGACTACGGA
ACGCCGCAGCATCGGCAACGCCTTTTCCTCATCGGAGCGAAGCGAGGCGAGACGCTTCCCGAGATCCCCCCGCCCCAGAC
GAATGCAGCCGACGCGCGAAAACCGCTCGCTCACCTTCCTGGCGGCCCGACCGTTCGGGACGCGATCGAGGACCTTCCCG
ATGCAGATCGGTTCGCCTCGCTCGTGGAGAGCGACGCTGTTCGGACCTCTGCCATGGGCGAGCCGTCTACCTACGCGGCC
GAATTGCGCTGCCTGAACAACGATGCCTGGCATTACGGCTATCCCCGGAACTGGACGCCGACATGGATGACATCCAGCGC
GCGCACGGCCCATTCGGAAATTTCTCGCCGGCGCTTCCAAGAGACCCCGCAAGGGGCGGTTGAGCCGATCAGCCGCTTCT
ACAAGCTGGCACCGGGCGGCCTTTGCAACACTCTGAGGGCAGGCACTGACGGTGCCCGGGGGGCCTTCACCAGTCCTCGG
CCGATCCACTACGAGTACAACCGCTGCATCACCGTGCGCGAGATGGCGCGGCTTCACGGGTTCCCCGATTGGTTCAGGCT
CCACGCCACTAAGTGGCATGGCGGAAGGCAAGTCGGCAACTCCGTGCCGCCGCCCCTCGCCCGCGCGGTCGCCTCCGAGA
TAGTCCGAGCACTGGGCGTCGCCCCGGAGCGGCCTGCGCGTGCAATCGATTTGGGAGAGCCCTCGTTGCTCTACATGGAG
ATGTCGGAAGCGGCGGAGCACTTCGGAGTGGCAGCGCCGTCCTCGCGGCGCGACCGAAAGAGCGGCGCAAAGAAGCGCAA
GCAGCACGAGATCGAAGCGGCGCGTGTCCAATTACGTGTGGTAAATGGCTGA

Upstream 100 bases:

>100_bases
GCGGTTGTGCGCATTCCTCGGGCCGACGAAAACCGATCGACAAGCATGATGCGGTAGGCTAATCTGCAGTCCGATCCGCG
CCAGCCGAGGAAGCAAACCT

Downstream 100 bases:

>100_bases
TCCTGAACCCGAGAACGTTTCGGCAGAAGCCCAGGCGGCCGTCACTTCCGCCGAGCCGAAGACATTGAACGCCTATCAGG
CGATCATCGTCGACATCTTC

Product: cytosine-specific DNA methylase

Products: NA

Alternate protein names: M.XorII; Cytosine-specific methyltransferase XorII [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MRPIGIDLFAGAGGLSLGFEQAGFDVAAAVEIDPVHCAVHKFNFPDTAVIPRSVVGLTAEEIRESAGIGNRPIDCVFGGP
PCQGFSLIGHRALEDPRNSLVLEFVRLVRELDARTFVFENVKGLTVGSHRTFLSELVAAFGMAGYDVRLPWKVLDAADYG
TPQHRQRLFLIGAKRGETLPEIPPPQTNAADARKPLAHLPGGPTVRDAIEDLPDADRFASLVESDAVRTSAMGEPSTYAA
ELRCLNNDAWHYGYPRNWTPTWMTSSARTAHSEISRRRFQETPQGAVEPISRFYKLAPGGLCNTLRAGTDGARGAFTSPR
PIHYEYNRCITVREMARLHGFPDWFRLHATKWHGGRQVGNSVPPPLARAVASEIVRALGVAPERPARAIDLGEPSLLYME
MSEAAEHFGVAAPSSRRDRKSGAKKRKQHEIEAARVQLRVVNG

Sequences:

>Translated_443_residues
MRPIGIDLFAGAGGLSLGFEQAGFDVAAAVEIDPVHCAVHKFNFPDTAVIPRSVVGLTAEEIRESAGIGNRPIDCVFGGP
PCQGFSLIGHRALEDPRNSLVLEFVRLVRELDARTFVFENVKGLTVGSHRTFLSELVAAFGMAGYDVRLPWKVLDAADYG
TPQHRQRLFLIGAKRGETLPEIPPPQTNAADARKPLAHLPGGPTVRDAIEDLPDADRFASLVESDAVRTSAMGEPSTYAA
ELRCLNNDAWHYGYPRNWTPTWMTSSARTAHSEISRRRFQETPQGAVEPISRFYKLAPGGLCNTLRAGTDGARGAFTSPR
PIHYEYNRCITVREMARLHGFPDWFRLHATKWHGGRQVGNSVPPPLARAVASEIVRALGVAPERPARAIDLGEPSLLYME
MSEAAEHFGVAAPSSRRDRKSGAKKRKQHEIEAARVQLRVVNG
>Mature_443_residues
MRPIGIDLFAGAGGLSLGFEQAGFDVAAAVEIDPVHCAVHKFNFPDTAVIPRSVVGLTAEEIRESAGIGNRPIDCVFGGP
PCQGFSLIGHRALEDPRNSLVLEFVRLVRELDARTFVFENVKGLTVGSHRTFLSELVAAFGMAGYDVRLPWKVLDAADYG
TPQHRQRLFLIGAKRGETLPEIPPPQTNAADARKPLAHLPGGPTVRDAIEDLPDADRFASLVESDAVRTSAMGEPSTYAA
ELRCLNNDAWHYGYPRNWTPTWMTSSARTAHSEISRRRFQETPQGAVEPISRFYKLAPGGLCNTLRAGTDGARGAFTSPR
PIHYEYNRCITVREMARLHGFPDWFRLHATKWHGGRQVGNSVPPPLARAVASEIVRALGVAPERPARAIDLGEPSLLYME
MSEAAEHFGVAAPSSRRDRKSGAKKRKQHEIEAARVQLRVVNG

Specific function: This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI195927037, Length=262, Percent_Identity=31.6793893129771, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4503351, Length=262, Percent_Identity=31.6793893129771, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4758184, Length=193, Percent_Identity=28.4974093264249, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 48521; Mature: 48521

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00094 C5_MTASE_1 ; PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPIGIDLFAGAGGLSLGFEQAGFDVAAAVEIDPVHCAVHKFNFPDTAVIPRSVVGLTAE
CCCCCEEEEECCCCCCCCHHHCCCCEEEEEEECCEEEEEEECCCCCCHHCCHHHHHCCHH
EIRESAGIGNRPIDCVFGGPPCQGFSLIGHRALEDPRNSLVLEFVRLVRELDARTFVFEN
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEHHC
VKGLTVGSHRTFLSELVAAFGMAGYDVRLPWKVLDAADYGTPQHRQRLFLIGAKRGETLP
CCCEEECCHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCCHHHCEEEEEECCCCCCCC
EIPPPQTNAADARKPLAHLPGGPTVRDAIEDLPDADRFASLVESDAVRTSAMGEPSTYAA
CCCCCCCCCHHHHCCHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
ELRCLNNDAWHYGYPRNWTPTWMTSSARTAHSEISRRRFQETPQGAVEPISRFYKLAPGG
HHEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
LCNTLRAGTDGARGAFTSPRPIHYEYNRCITVREMARLHGFPDWFRLHATKWHGGRQVGN
HHHHHHCCCCCCCCCCCCCCCEEEECCCEEHHHHHHHHCCCCHHHHEEEEECCCCHHCCC
SVPPPLARAVASEIVRALGVAPERPARAIDLGEPSLLYMEMSEAAEHFGVAAPSSRRDRK
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEHHHHHHHHCCCCCCCHHHHH
SGAKKRKQHEIEAARVQLRVVNG
HHHHHHHHHHHHEEEEEEEEECC
>Mature Secondary Structure
MRPIGIDLFAGAGGLSLGFEQAGFDVAAAVEIDPVHCAVHKFNFPDTAVIPRSVVGLTAE
CCCCCEEEEECCCCCCCCHHHCCCCEEEEEEECCEEEEEEECCCCCCHHCCHHHHHCCHH
EIRESAGIGNRPIDCVFGGPPCQGFSLIGHRALEDPRNSLVLEFVRLVRELDARTFVFEN
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEHHC
VKGLTVGSHRTFLSELVAAFGMAGYDVRLPWKVLDAADYGTPQHRQRLFLIGAKRGETLP
CCCEEECCHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCCHHHCEEEEEECCCCCCCC
EIPPPQTNAADARKPLAHLPGGPTVRDAIEDLPDADRFASLVESDAVRTSAMGEPSTYAA
CCCCCCCCCHHHHCCHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
ELRCLNNDAWHYGYPRNWTPTWMTSSARTAHSEISRRRFQETPQGAVEPISRFYKLAPGG
HHEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
LCNTLRAGTDGARGAFTSPRPIHYEYNRCITVREMARLHGFPDWFRLHATKWHGGRQVGN
HHHHHHCCCCCCCCCCCCCCCEEEECCCEEHHHHHHHHCCCCHHHHEEEEECCCCHHCCC
SVPPPLARAVASEIVRALGVAPERPARAIDLGEPSLLYMEMSEAAEHFGVAAPSSRRDRK
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEHHHHHHHHCCCCCCCHHHHH
SGAKKRKQHEIEAARVQLRVVNG
HHHHHHHHHHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8078464 [H]