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The map label for this gene is php [H]

Identifier: 77465698

GI number: 77465698

Start: 811358

End: 812422

Strand: Direct

Name: php [H]

Synonym: RSP_3690

Alternate gene names: 77465698

Gene position: 811358-812422 (Clockwise)

Preceding gene: 77465697

Following gene: 77465699

Centisome position: 86.04

GC content: 67.61

Gene sequence:

>1065_bases
ATGAGCGAGCTTTCTCCCTGCCACGTCCGCTCGGGCCGGATCATGACGGTGGACGGGCCGATCCCGTCCTCCGCCCTCGG
CCACACGCTGATGCACGAGCATCTGCAGAACGACTGCCGCTGCTGGTGGAACCCGCCGCAGGAGCCCGAGCGCCAGTATC
TGGCCGAGGCGCCGATCAGCATCGAGATCCTGTCCGAACTCCGGCAGGACCCGTTCGTGAACAAGCACAACATCGCGCTC
GACGATCTGGATCTGGCCATCGCCGAGGTAAAGCAGTTCGCCGCGGTGGGCGGGCGAAGCATCGTCGATCCGACCTGCCG
CGGCATCGGGCGCGATCCGGTGAAGCTGCGCCGGATCTCGGCCGAGACCGGCGTGCAGGTGGTGATGGGGGCGGGCTACT
ATCTCGCAAGCTCCATGCCCGAGACCGCGGCGCGGCTCTCGGCCGATGACATTGCCGACGAGATCGTGGCCGAGGCGCTG
GAGGGCACCGACGGGACCGATGCGCGCATCGGGCTGATCGGCGAGATCGGCGTTTCCTCGGACTTCACGGCCGAGGAGGA
GAAGTCGCTCCGCGGCGCGGCCCGGGCGCAGGTCCGCACCGGCCTGCCGCTCATGGTGCATCTGCCGGGCTGGTTCCGCC
TCGCGCACCGCGTGCTCGACCTCGTCGAAGAGGAGGGAGCCGACCTGCGCCACACGGTCCTGTGCCACATGAACCCCTCG
CACATGGACCCGGTCTATCAGGCGACACTGGCCCAGCGCGGCGCCTTCCTCGAGTTCGACATGATCGGCATGGATTTCTT
CTATGCCGATCAGGGGGTGCAGTGCCCCTCGGACGACGAGGTGGCCCGCGCGATCCTCGGGCTTGCGGATCACGGCTATC
TCGACCGGATCCTGCTGTCGCACGATGTCTTCGTGAAGATGATGCTCACCCGCTACGGCGGCAACGGCTACGCCTTCGTG
ACGAAGCACTTCCTGCCGCGTCTGCGGCGCCACGGGCTGGACGATGCGGCCCTCGAGACGCTGATGGTGACGAACCCGCG
CCGGGTCTTCGACGCCTCCATCTAA

Upstream 100 bases:

>100_bases
TCTTCACCCAGATCGTCACAGGCACCATCATCCTCGTCGCCATCTGGATGAACACGCGGCTCTTCGATCGCCCCTGGCGC
TTCGGACGGAGGAAACCGGC

Downstream 100 bases:

>100_bases
CATTTCCTGCAAGGACAAGATCATGAGCACCAAGATACTGCTGGTTGGCGAAAGCTGGACGACCTCCGAAACCCATTACA
AGGGCTTCGACCAGTTCGGC

Product: resiniferatoxin-binding, phosphotriesterase-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSELSPCHVRSGRIMTVDGPIPSSALGHTLMHEHLQNDCRCWWNPPQEPERQYLAEAPISIEILSELRQDPFVNKHNIAL
DDLDLAIAEVKQFAAVGGRSIVDPTCRGIGRDPVKLRRISAETGVQVVMGAGYYLASSMPETAARLSADDIADEIVAEAL
EGTDGTDARIGLIGEIGVSSDFTAEEEKSLRGAARAQVRTGLPLMVHLPGWFRLAHRVLDLVEEEGADLRHTVLCHMNPS
HMDPVYQATLAQRGAFLEFDMIGMDFFYADQGVQCPSDDEVARAILGLADHGYLDRILLSHDVFVKMMLTRYGGNGYAFV
TKHFLPRLRRHGLDDAALETLMVTNPRRVFDASI

Sequences:

>Translated_354_residues
MSELSPCHVRSGRIMTVDGPIPSSALGHTLMHEHLQNDCRCWWNPPQEPERQYLAEAPISIEILSELRQDPFVNKHNIAL
DDLDLAIAEVKQFAAVGGRSIVDPTCRGIGRDPVKLRRISAETGVQVVMGAGYYLASSMPETAARLSADDIADEIVAEAL
EGTDGTDARIGLIGEIGVSSDFTAEEEKSLRGAARAQVRTGLPLMVHLPGWFRLAHRVLDLVEEEGADLRHTVLCHMNPS
HMDPVYQATLAQRGAFLEFDMIGMDFFYADQGVQCPSDDEVARAILGLADHGYLDRILLSHDVFVKMMLTRYGGNGYAFV
TKHFLPRLRRHGLDDAALETLMVTNPRRVFDASI
>Mature_353_residues
SELSPCHVRSGRIMTVDGPIPSSALGHTLMHEHLQNDCRCWWNPPQEPERQYLAEAPISIEILSELRQDPFVNKHNIALD
DLDLAIAEVKQFAAVGGRSIVDPTCRGIGRDPVKLRRISAETGVQVVMGAGYYLASSMPETAARLSADDIADEIVAEALE
GTDGTDARIGLIGEIGVSSDFTAEEEKSLRGAARAQVRTGLPLMVHLPGWFRLAHRVLDLVEEEGADLRHTVLCHMNPSH
MDPVYQATLAQRGAFLEFDMIGMDFFYADQGVQCPSDDEVARAILGLADHGYLDRILLSHDVFVKMMLTRYGGNGYAFVT
KHFLPRLRRHGLDDAALETLMVTNPRRVFDASI

Specific function: Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates:P- nitrophenyl acetate, L-alan

COG id: COG1735

COG function: function code R; Predicted metal-dependent hydrolase with the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphotriesterase family [H]

Homologues:

Organism=Homo sapiens, GI20070186, Length=341, Percent_Identity=32.5513196480938, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI47933341, Length=341, Percent_Identity=32.5513196480938, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI1789780, Length=281, Percent_Identity=30.6049822064057, Blast_Score=132, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24645325, Length=342, Percent_Identity=26.9005847953216, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017947
- InterPro:   IPR001559 [H]

Pfam domain/function: PF02126 PTE [H]

EC number: NA

Molecular weight: Translated: 39099; Mature: 38968

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01322 PHOSPHOTRIESTERASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSPCHVRSGRIMTVDGPIPSSALGHTLMHEHLQNDCRCWWNPPQEPERQYLAEAPIS
CCCCCCCEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHCCCH
IEILSELRQDPFVNKHNIALDDLDLAIAEVKQFAAVGGRSIVDPTCRGIGRDPVKLRRIS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHEEEC
AETGVQVVMGAGYYLASSMPETAARLSADDIADEIVAEALEGTDGTDARIGLIGEIGVSS
HHCCCEEEEECCHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
DFTAEEEKSLRGAARAQVRTGLPLMVHLPGWFRLAHRVLDLVEEEGADLRHTVLCHMNPS
CCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHH
HMDPVYQATLAQRGAFLEFDMIGMDFFYADQGVQCPSDDEVARAILGLADHGYLDRILLS
HCCHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
HDVFVKMMLTRYGGNGYAFVTKHFLPRLRRHGLDDAALETLMVTNPRRVFDASI
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
SELSPCHVRSGRIMTVDGPIPSSALGHTLMHEHLQNDCRCWWNPPQEPERQYLAEAPIS
CCCCCCEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHCCCH
IEILSELRQDPFVNKHNIALDDLDLAIAEVKQFAAVGGRSIVDPTCRGIGRDPVKLRRIS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHEEEC
AETGVQVVMGAGYYLASSMPETAARLSADDIADEIVAEALEGTDGTDARIGLIGEIGVSS
HHCCCEEEEECCHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
DFTAEEEKSLRGAARAQVRTGLPLMVHLPGWFRLAHRVLDLVEEEGADLRHTVLCHMNPS
CCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHH
HMDPVYQATLAQRGAFLEFDMIGMDFFYADQGVQCPSDDEVARAILGLADHGYLDRILLS
HCCHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
HDVFVKMMLTRYGGNGYAFVTKHFLPRLRRHGLDDAALETLMVTNPRRVFDASI
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9548740 [H]