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The map label for this gene is groEL

Identifier: 77465622

GI number: 77465622

Start: 723944

End: 725572

Strand: Reverse

Name: groEL

Synonym: RSP_3615

Alternate gene names: 77465622

Gene position: 725572-723944 (Counterclockwise)

Preceding gene: 77465624

Following gene: 77465621

Centisome position: 76.94

GC content: 62.68

Gene sequence:

>1629_bases
ATGTCCGCTAAAGAAGTTCGATTCGGTACCGACGCCCGCGGCCGTATGCTGAAAGGCATCAACACGCTGGCCGATACGGT
CAAGATCACCCTCGGCCCGAAGGGCAGAAATGTCATTCTCGACACGTCCTATGGCGCGCCCCGTATCACCAAGGACGGCG
TGACCGTCGCCAGGGAGATCGAGTTGTCGGACCGTTTCGAGAACGTGGGCGCCCAGATGGTGAAGGAAGTGGCCAGCCGC
ACCAACGAGGAGGCCGGCGACGGCACGACCACGGCAACGGTTCTGGCACAGGCCATTGCCAAGGAAGGCATGAAGGCGGT
CGCGGCCGGCATGAATCCGATGGATCTGAAGCGGGGGATCGACCGCGCGGTGGCCATCGTCATAGCCGAGATCAGGTCCA
TGTCCCGACCGGTCGGAGACAGCGCCGAAATTGCGAAGGTCGGGGCCCTATCGGCCAATGGCGAGGCGGCGATCGGCCGT
CAGATCGCCGATGCAATGGCGAAGGTCGGCACTGCGGGGGTGATCAAGGTAGAGGAGAATAAGGGCCTCGAGACCGAAAC
CGAGGTGGTGGAAGGCATGCAGTTCGACCGCGGTTACCTGAGCCCCTATTTCATCACTCATGCGCAGAAGATGGTCGTGG
AATTGGACGACTGCGCCATCCTGCTCCACGAAGGCAAGCTGACCTCGCTTGCTTCGATGGTGCCGTTGCTGGAAGCGGTC
GTTCAGGCAGAAAAGCAACTTCTCGTCGTGGCCGAGGACGTCGAGGGCGAGGCTCTGACGACCCTGGTGGTCAACAAGCT
GCGCGGCGGTCTCAAGGTTGCGGCAGCAAAGGCACCCGGCTTCGGGGATGGGCGTGCGGCGATGCTGGAGGATCTTGCAG
TCCTGACGGGCGCGCACCTCATCTCGGCCGAGCTCGGGACGAAGCTGGAAACCGTCACGCTGGACATGCTCGGTTTTGCG
AAGAAGGTTGTCCTGACGAAGGACAGCACCATCCTCATCGACAGTGCCGGCGACAAGGCGGCGATCGCTTCACGCATCGG
CCAGATCCGCAACCAGATCGAGGATACGACGTCGGCCTACAACAAGGAGAAGTTGCAGGAACGTCTGGCGAGACTCGCGG
GCGGAGTTGCTGTCATTCGGGTCGGGGGTGCCACCGAAATCGAAGTGAAGGAGCGCAGGGACAGGGTGGAGGACACCCTC
AACGCCACCCGCGCCGCGGTACAGGAGGGCGTCGTGCCCGGCGGCGGGGCCGCACTGATTCATGCGGGCAAGGCTCTGGC
GGGCTTGAAGGGCGACAATCCCGATCAGGATGCAGGCATCAAGATCATCCGCCGCGCAATCCAGGCGCCGCTGCGCCAGA
TCGCCGACAACGCCGGGATCGACGGATCGGTCGTCGCCGGCAAGGTCATCGAGAACGACAGCGCAACCTTTGGCTTCGAT
GCGCAGTTGGAGACGTACGGCGATATGCTGCAGGCCGGCATCATCGATCCGACCAAGGTCGTGCGGATAGCATTGGAGGA
CGCCGCATCGATCGCAGGCCTGCTGATCACGACGGAGGTGATCATCGCGCATAAGCCGGAAAGGGGCGAACGAATGTCCC
AGATGGATGAGATGGGCGGCATGATGTGA

Upstream 100 bases:

>100_bases
ACCGGCGAACACCCTCTGATCATGAAGGAGGCCGACATTCTCGGCGTGATCGCCTGAGCCCGTAAACCTTCCCTGCAATC
TCAGCCTCAGGAACCCGCGA

Downstream 100 bases:

>100_bases
GGTTCGCCCGCTGCGTCGATCCCTGATGTCTGCATTTGCACTCAGGCAATCCGCTCCTCCCCGAACTGATCGCCAGAATC
GCGTTACAGTCCCACCAAGA

Product: chaperonin Cpn60

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSAKEVRFGTDARGRMLKGINTLADTVKITLGPKGRNVILDTSYGAPRITKDGVTVAREIELSDRFENVGAQMVKEVASR
TNEEAGDGTTTATVLAQAIAKEGMKAVAAGMNPMDLKRGIDRAVAIVIAEIRSMSRPVGDSAEIAKVGALSANGEAAIGR
QIADAMAKVGTAGVIKVEENKGLETETEVVEGMQFDRGYLSPYFITHAQKMVVELDDCAILLHEGKLTSLASMVPLLEAV
VQAEKQLLVVAEDVEGEALTTLVVNKLRGGLKVAAAKAPGFGDGRAAMLEDLAVLTGAHLISAELGTKLETVTLDMLGFA
KKVVLTKDSTILIDSAGDKAAIASRIGQIRNQIEDTTSAYNKEKLQERLARLAGGVAVIRVGGATEIEVKERRDRVEDTL
NATRAAVQEGVVPGGGAALIHAGKALAGLKGDNPDQDAGIKIIRRAIQAPLRQIADNAGIDGSVVAGKVIENDSATFGFD
AQLETYGDMLQAGIIDPTKVVRIALEDAASIAGLLITTEVIIAHKPERGERMSQMDEMGGMM

Sequences:

>Translated_542_residues
MSAKEVRFGTDARGRMLKGINTLADTVKITLGPKGRNVILDTSYGAPRITKDGVTVAREIELSDRFENVGAQMVKEVASR
TNEEAGDGTTTATVLAQAIAKEGMKAVAAGMNPMDLKRGIDRAVAIVIAEIRSMSRPVGDSAEIAKVGALSANGEAAIGR
QIADAMAKVGTAGVIKVEENKGLETETEVVEGMQFDRGYLSPYFITHAQKMVVELDDCAILLHEGKLTSLASMVPLLEAV
VQAEKQLLVVAEDVEGEALTTLVVNKLRGGLKVAAAKAPGFGDGRAAMLEDLAVLTGAHLISAELGTKLETVTLDMLGFA
KKVVLTKDSTILIDSAGDKAAIASRIGQIRNQIEDTTSAYNKEKLQERLARLAGGVAVIRVGGATEIEVKERRDRVEDTL
NATRAAVQEGVVPGGGAALIHAGKALAGLKGDNPDQDAGIKIIRRAIQAPLRQIADNAGIDGSVVAGKVIENDSATFGFD
AQLETYGDMLQAGIIDPTKVVRIALEDAASIAGLLITTEVIIAHKPERGERMSQMDEMGGMM
>Mature_541_residues
SAKEVRFGTDARGRMLKGINTLADTVKITLGPKGRNVILDTSYGAPRITKDGVTVAREIELSDRFENVGAQMVKEVASRT
NEEAGDGTTTATVLAQAIAKEGMKAVAAGMNPMDLKRGIDRAVAIVIAEIRSMSRPVGDSAEIAKVGALSANGEAAIGRQ
IADAMAKVGTAGVIKVEENKGLETETEVVEGMQFDRGYLSPYFITHAQKMVVELDDCAILLHEGKLTSLASMVPLLEAVV
QAEKQLLVVAEDVEGEALTTLVVNKLRGGLKVAAAKAPGFGDGRAAMLEDLAVLTGAHLISAELGTKLETVTLDMLGFAK
KVVLTKDSTILIDSAGDKAAIASRIGQIRNQIEDTTSAYNKEKLQERLARLAGGVAVIRVGGATEIEVKERRDRVEDTLN
ATRAAVQEGVVPGGGAALIHAGKALAGLKGDNPDQDAGIKIIRRAIQAPLRQIADNAGIDGSVVAGKVIENDSATFGFDA
QLETYGDMLQAGIIDPTKVVRIALEDAASIAGLLITTEVIIAHKPERGERMSQMDEMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=51.5209125475285, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=51.5209125475285, Blast_Score=531, Evalue=1e-151,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=61.5530303030303, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=526, Percent_Identity=49.6197718631179, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI193210679, Length=219, Percent_Identity=47.4885844748858, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17564182, Length=546, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147750, Length=144, Percent_Identity=34.0277777777778, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=52.6717557251908, Blast_Score=535, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322524, Length=534, Percent_Identity=20.9737827715356, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.7001897533207, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.7001897533207, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=51.4285714285714, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=51.4285714285714, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=51.4285714285714, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=43.0147058823529, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=36.8421052631579, Blast_Score=321, Evalue=1e-87,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=36.8421052631579, Blast_Score=321, Evalue=1e-87,
Organism=Drosophila melanogaster, GI28571140, Length=555, Percent_Identity=23.4234234234234, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18858175, Length=555, Percent_Identity=23.4234234234234, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_RHOS4 (Q3IW60)

Other databases:

- EMBL:   CP000144
- RefSeq:   YP_355125.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q3IW60
- SMR:   Q3IW60
- STRING:   Q3IW60
- GeneID:   3721779
- GenomeReviews:   CP000144_GR
- KEGG:   rsp:RSP_3615
- NMPDR:   fig|272943.3.peg.3419
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   IENDSAT
- PhylomeDB:   Q3IW60
- ProtClustDB:   CLSK2516856
- BioCyc:   RSPH272943:RSP_3615-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57009; Mature: 56878

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKEVRFGTDARGRMLKGINTLADTVKITLGPKGRNVILDTSYGAPRITKDGVTVAREI
CCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCCCEECCCCEEEEEE
ELSDRFENVGAQMVKEVASRTNEEAGDGTTTATVLAQAIAKEGMKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DRAVAIVIAEIRSMSRPVGDSAEIAKVGALSANGEAAIGRQIADAMAKVGTAGVIKVEEN
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
KGLETETEVVEGMQFDRGYLSPYFITHAQKMVVELDDCAILLHEGKLTSLASMVPLLEAV
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHHHHH
VQAEKQLLVVAEDVEGEALTTLVVNKLRGGLKVAAAKAPGFGDGRAAMLEDLAVLTGAHL
HHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
ISAELGTKLETVTLDMLGFAKKVVLTKDSTILIDSAGDKAAIASRIGQIRNQIEDTTSAY
HHHHHCCCCHHEEHHHHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NKEKLQERLARLAGGVAVIRVGGATEIEVKERRDRVEDTLNATRAAVQEGVVPGGGAALI
HHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEE
HAGKALAGLKGDNPDQDAGIKIIRRAIQAPLRQIADNAGIDGSVVAGKVIENDSATFGFD
ECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
AQLETYGDMLQAGIIDPTKVVRIALEDAASIAGLLITTEVIIAHKPERGERMSQMDEMGG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCC
MM
CC
>Mature Secondary Structure 
SAKEVRFGTDARGRMLKGINTLADTVKITLGPKGRNVILDTSYGAPRITKDGVTVAREI
CCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCCCEECCCCEEEEEE
ELSDRFENVGAQMVKEVASRTNEEAGDGTTTATVLAQAIAKEGMKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DRAVAIVIAEIRSMSRPVGDSAEIAKVGALSANGEAAIGRQIADAMAKVGTAGVIKVEEN
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
KGLETETEVVEGMQFDRGYLSPYFITHAQKMVVELDDCAILLHEGKLTSLASMVPLLEAV
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHHHHHHH
VQAEKQLLVVAEDVEGEALTTLVVNKLRGGLKVAAAKAPGFGDGRAAMLEDLAVLTGAHL
HHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
ISAELGTKLETVTLDMLGFAKKVVLTKDSTILIDSAGDKAAIASRIGQIRNQIEDTTSAY
HHHHHCCCCHHEEHHHHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NKEKLQERLARLAGGVAVIRVGGATEIEVKERRDRVEDTLNATRAAVQEGVVPGGGAALI
HHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEE
HAGKALAGLKGDNPDQDAGIKIIRRAIQAPLRQIADNAGIDGSVVAGKVIENDSATFGFD
ECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCC
AQLETYGDMLQAGIIDPTKVVRIALEDAASIAGLLITTEVIIAHKPERGERMSQMDEMGG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCC
MM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA