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The map label for this gene is aphA [H]

Identifier: 77465527

GI number: 77465527

Start: 608012

End: 609046

Strand: Direct

Name: aphA [H]

Synonym: RSP_3527

Alternate gene names: 77465527

Gene position: 608012-609046 (Clockwise)

Preceding gene: 77465526

Following gene: 77465534

Centisome position: 64.48

GC content: 69.28

Gene sequence:

>1035_bases
ATGAAGACGATCTTCTCCGACAAGCACGCGCTGCAGAGCGTGGAGCGCGAATTCTACCGGGGCGGCTGGGTGGAGGCGTT
CGAGATCCCCCGCCGCGCCGAACTCGTGCTGGCCGCCGTCACGCGCGCGGGCCTGGGCCCCGTGACAGCGCCGCAGCCGT
TCGACCTCGGGCCCGTGCTGGCCGTTCATGATGCGGCCTTCGTGCGCTTTCTGGAAGGCGCCTGGGAGAGCTGGGTGGCC
GAGATGGGCCCGGTTCCGGCCTATCCCAACCTCTGGCCGCCGCGCCGGTCGCGGACGATCCCGACGGTCCGGCCCGGCGC
CGAACTCGGCCGCTATGTCGTCGACATGAGCAGCCCGGTCCTTACGGGCACATGGGAGGCCGCGCGGGCGGGTGTCGACT
GCGCCCTGACCGGCGTGGCCCTGATCGAATCGGGCGAGCCCGCGGCCTTCGCCCTCAGCCGTCCCCCGGGCCACCATGCG
GGGCGCGACTATTTCGGCGGCTACTGCTTTCTTAACAATGCGGCGATCGCCGCGCAGCAGTTCCGCAGCCTCGGCGCGGA
GCGGGTGGCGGTGCTCGACATCGACTATCACCACGGCAACGGCACGCAGGACATCTTCTACGACCGCGGCGACGTGCTGA
CCGTCTCGGTCCATGCCGATCCGGTGCAGGACTATCCCTATTATATCGGCTTCGCCGACGAGACCGGCGAGGGTGAGGGA
GCGGGTGCGAACCTGAACCTGCCGCTGCCCTGGGGCGCGGATTTCGCCTCCTACCGCAGCGCGCTTGCCGAAGGCCTGGC
GCGGATCCGGGCCTTCGCGCCCGACCGGCTGGTGGTGTCTCTGGGCGTCGACACGTTCATGGACGATCCGATCTCGCAGT
TCCGGCTGGAGAGCGGGGATTACCCCCGGATCGGCGCGATGATCGCCGCCCTCGGCCTGCCCACCCTCTTCGTGATGGAG
GGCGGCTATGCCATCGAGGCCATCGGCGAGAATGTCGTGCAGCTTCTGAAGGGATATGAGGCGGAGCGCGGCTGA

Upstream 100 bases:

>100_bases
GACCAGAGCGTCTTCACGGCGGGCCTCGCCTACGAGACCGCTCTCGGCGGCTGGTATGGCACCGCCGCAACCCGTCCCTC
CCTGCCCTTCTGAGGTCCCG

Downstream 100 bases:

>100_bases
GCCCTCAGCCGCCCCCCGCGGAGTCAGAAGTCGTCGGGGAAGATCAGCCTCAGATAGGCCAGCGAGGCATCGTGCCCGCG
CTTCTGCCCCTCTGCGATGG

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKTIFSDKHALQSVEREFYRGGWVEAFEIPRRAELVLAAVTRAGLGPVTAPQPFDLGPVLAVHDAAFVRFLEGAWESWVA
EMGPVPAYPNLWPPRRSRTIPTVRPGAELGRYVVDMSSPVLTGTWEAARAGVDCALTGVALIESGEPAAFALSRPPGHHA
GRDYFGGYCFLNNAAIAAQQFRSLGAERVAVLDIDYHHGNGTQDIFYDRGDVLTVSVHADPVQDYPYYIGFADETGEGEG
AGANLNLPLPWGADFASYRSALAEGLARIRAFAPDRLVVSLGVDTFMDDPISQFRLESGDYPRIGAMIAALGLPTLFVME
GGYAIEAIGENVVQLLKGYEAERG

Sequences:

>Translated_344_residues
MKTIFSDKHALQSVEREFYRGGWVEAFEIPRRAELVLAAVTRAGLGPVTAPQPFDLGPVLAVHDAAFVRFLEGAWESWVA
EMGPVPAYPNLWPPRRSRTIPTVRPGAELGRYVVDMSSPVLTGTWEAARAGVDCALTGVALIESGEPAAFALSRPPGHHA
GRDYFGGYCFLNNAAIAAQQFRSLGAERVAVLDIDYHHGNGTQDIFYDRGDVLTVSVHADPVQDYPYYIGFADETGEGEG
AGANLNLPLPWGADFASYRSALAEGLARIRAFAPDRLVVSLGVDTFMDDPISQFRLESGDYPRIGAMIAALGLPTLFVME
GGYAIEAIGENVVQLLKGYEAERG
>Mature_344_residues
MKTIFSDKHALQSVEREFYRGGWVEAFEIPRRAELVLAAVTRAGLGPVTAPQPFDLGPVLAVHDAAFVRFLEGAWESWVA
EMGPVPAYPNLWPPRRSRTIPTVRPGAELGRYVVDMSSPVLTGTWEAARAGVDCALTGVALIESGEPAAFALSRPPGHHA
GRDYFGGYCFLNNAAIAAQQFRSLGAERVAVLDIDYHHGNGTQDIFYDRGDVLTVSVHADPVQDYPYYIGFADETGEGEG
AGANLNLPLPWGADFASYRSALAEGLARIRAFAPDRLVVSLGVDTFMDDPISQFRLESGDYPRIGAMIAALGLPTLFVME
GGYAIEAIGENVVQLLKGYEAERG

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=229, Percent_Identity=31.4410480349345, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI30795202, Length=229, Percent_Identity=31.4410480349345, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI17158039, Length=229, Percent_Identity=31.4410480349345, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI153085395, Length=229, Percent_Identity=33.1877729257642, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI20070354, Length=216, Percent_Identity=34.2592592592593, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13128864, Length=323, Percent_Identity=26.0061919504644, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI148539870, Length=191, Percent_Identity=32.4607329842932, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI169234807, Length=191, Percent_Identity=32.4607329842932, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13128860, Length=241, Percent_Identity=25.7261410788382, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI8923769, Length=169, Percent_Identity=31.3609467455621, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI262073088, Length=169, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI62750349, Length=215, Percent_Identity=30.6976744186047, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI62750347, Length=215, Percent_Identity=30.6976744186047, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI226529806, Length=215, Percent_Identity=31.1627906976744, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI13128862, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI293336691, Length=242, Percent_Identity=25.2066115702479, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17540332, Length=257, Percent_Identity=32.295719844358, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=257, Percent_Identity=32.295719844358, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540334, Length=247, Percent_Identity=32.7935222672065, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17537347, Length=231, Percent_Identity=30.7359307359307, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=249, Percent_Identity=28.1124497991968, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193209491, Length=268, Percent_Identity=27.6119402985075, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=232, Percent_Identity=25.8620689655172, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25154022, Length=223, Percent_Identity=27.8026905829596, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561978, Length=221, Percent_Identity=24.4343891402715, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=206, Percent_Identity=36.8932038834951, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323999, Length=226, Percent_Identity=28.7610619469027, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321244, Length=219, Percent_Identity=28.310502283105, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325141, Length=100, Percent_Identity=39, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642144, Length=226, Percent_Identity=33.1858407079646, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360899, Length=226, Percent_Identity=33.1858407079646, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642142, Length=226, Percent_Identity=33.1858407079646, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642146, Length=226, Percent_Identity=33.1858407079646, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360799, Length=228, Percent_Identity=31.140350877193, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281360801, Length=228, Percent_Identity=31.140350877193, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24641720, Length=228, Percent_Identity=31.140350877193, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24657891, Length=241, Percent_Identity=25.3112033195021, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24644244, Length=224, Percent_Identity=27.2321428571429, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37190; Mature: 37190

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIFSDKHALQSVEREFYRGGWVEAFEIPRRAELVLAAVTRAGLGPVTAPQPFDLGPVL
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AVHDAAFVRFLEGAWESWVAEMGPVPAYPNLWPPRRSRTIPTVRPGAELGRYVVDMSSPV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCE
LTGTWEAARAGVDCALTGVALIESGEPAAFALSRPPGHHAGRDYFGGYCFLNNAAIAAQQ
EECCHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEECCHHHHHHH
FRSLGAERVAVLDIDYHHGNGTQDIFYDRGDVLTVSVHADPVQDYPYYIGFADETGEGEG
HHHCCCCEEEEEEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCC
AGANLNLPLPWGADFASYRSALAEGLARIRAFAPDRLVVSLGVDTFMDDPISQFRLESGD
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHCCCCCC
YPRIGAMIAALGLPTLFVMEGGYAIEAIGENVVQLLKGYEAERG
CCHHHHHHHHHCCCEEEEEECCEEEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTIFSDKHALQSVEREFYRGGWVEAFEIPRRAELVLAAVTRAGLGPVTAPQPFDLGPVL
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AVHDAAFVRFLEGAWESWVAEMGPVPAYPNLWPPRRSRTIPTVRPGAELGRYVVDMSSPV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCE
LTGTWEAARAGVDCALTGVALIESGEPAAFALSRPPGHHAGRDYFGGYCFLNNAAIAAQQ
EECCHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEECCHHHHHHH
FRSLGAERVAVLDIDYHHGNGTQDIFYDRGDVLTVSVHADPVQDYPYYIGFADETGEGEG
HHHCCCCEEEEEEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCC
AGANLNLPLPWGADFASYRSALAEGLARIRAFAPDRLVVSLGVDTFMDDPISQFRLESGD
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHCCCCCC
YPRIGAMIAALGLPTLFVMEGGYAIEAIGENVVQLLKGYEAERG
CCHHHHHHHHHCCCEEEEEECCEEEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]