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The map label for this gene is dppA [H]

Identifier: 77465524

GI number: 77465524

Start: 603069

End: 604673

Strand: Reverse

Name: dppA [H]

Synonym: RSP_3524

Alternate gene names: 77465524

Gene position: 604673-603069 (Counterclockwise)

Preceding gene: 77465525

Following gene: 77465523

Centisome position: 64.12

GC content: 68.35

Gene sequence:

>1605_bases
ATGCGCTACCCCACGGGCCCCATCGGCGGGCAGATCCTTGCGCAGGCCATGAGCCTCGCCCCCTCGCGACGGGCCTTTCT
GGGGGGCGCGGCCGCCGTGGCCGGCGCCTTCTGCCTGCCCGCCTCGCTGCGAGCCGAGGAAGGGCCGAAGCGGGGCGGCC
GGCTCCGCTACGGCGTCAACGACGGCTCGCAGCAGGATTCGCTCGAGCCCGGCAGCTGGGCCACCGTCATGTGCGGTGCG
GCCTTCAACGGCGCGCTCTGCAACAACCTCGTCGAGCTTCTGCCGGACGGGTCGCTGGCGGGCGATCTCGCCGAAAGCTG
GGAGGAGGCCGAGGGTGCCACCCGCTGGACCTTCACGCTCCGCAAGGGTGTCCTGTTCCACGACGGCCGCCCCTTCACCC
CGGAGGATGCCCGGCAGTCGCTGATGCATCACATGGGCGAGGGCAGCACCTCGGGCGCGCTCGCCATCGTCAGCCAGATC
AAGGAGATCGCCGTCGAGGGCGAGGACCGGCTGATCGTGACCCTCACGCAGGGCAATGCCGACTTCCCCTATCTGCTGTC
GGATTATCACCTCTCGATCTTCCCGGCGAAGGAGGGCGGCGGCATCGACTGGGAGAGCGGCATCGGCACCGGCGCCTTCA
AGCTCGACAGTTTCGAGCCGGGCGTCGCGGTCCGACTGCTCCGCAATCCGAACTATCACAAGCCCGGCCTGCCGCATTTC
GACGAGGTCGAATTCATCGCGATCCCCGACCGGTCCGCGCGGCTGAATGCGCTGCTGACCGGCGAGGTCGATGTGATCGA
GGATGTCGACATCCGCAACGTCCCCCTGATCGAGCGCAATCCCGATCTGGTGCTGCACCGCACGCCGAGCCTGCGGCACC
TGACCTTCGACATGAACTGCCAAACGGCGCCCTTCGACAATCCGGTCGTGCGCAAGGCCCTGAAGCTCAGCCTCGACCGC
GAGGATGTGATCGCCAAGGTGTTCCTCGGCGAGGCCGAGACGGGGAACGACAACCCGGTGGCGCGCATCATGCCCTTCTG
GGCCGAGACGCCGCCCGAGCACCGCTACGATCCCGAGGCCGCGCGGGCGCTTCTGGCCGAGGCCGGGATCGAGGGGCTGA
CGGTCGATCTCTCGGTGGCCGAATCCGCCTTTCCCGGTGCGGTCGAAGCGGGGGTCCTTTTCCGCGAACATGCCGCCAAG
GCCGGCATCACGATCAACCTCGTGCAGGAGGCCGATGACGGCTACTGGGACAATGTCTGGCTGGTGAAGCCCTTCAACGC
CGCCGACTGGTACGGGCGGGTCACGCTCGACTGGCTGTTCGCCACCTCCTACACCTCCGACGCGCCCTGGAACAACACGG
GGTTCAAGAACGCCCGCTTCGACGAGCTGCATGCGGCGGCGCGGTCGGAGACCGATCCCGCCACGCGGGGCGAACAGTAT
GCCGAGATGCAGCAGATCCTGCACGACGACGGCGGCGTGATCACGGTGGCCTTCGTGTCCTGGCTGCTCGCCATGTCGCG
CGCCATCGGCCATGGTGAGACCGGAGGCATCCTGCCCGCCGACAATCATCGCTGCGCCGAGCGGTGGTGGCGCACCGACG
TCTGA

Upstream 100 bases:

>100_bases
TCAAGGACTGAGGTCGGCAGGCCCGGTCTCAGACGGCCCGGAGCGCGAGGCGCGCCCCGGGCGACATTCCGACATTTTCG
TTCAGGGCGGAGAAAACCTG

Downstream 100 bases:

>100_bases
CACAACGGGGTGGGCGGACCTGCCTGACCGCCCTTTCACCCGAGCCTTGCCGGAGACAGCCGAGTATGAACAGAACTTCC
CATCCGATCTTGTCCATGGT

Product: ABC peptide transporter, periplasmic binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MRYPTGPIGGQILAQAMSLAPSRRAFLGGAAAVAGAFCLPASLRAEEGPKRGGRLRYGVNDGSQQDSLEPGSWATVMCGA
AFNGALCNNLVELLPDGSLAGDLAESWEEAEGATRWTFTLRKGVLFHDGRPFTPEDARQSLMHHMGEGSTSGALAIVSQI
KEIAVEGEDRLIVTLTQGNADFPYLLSDYHLSIFPAKEGGGIDWESGIGTGAFKLDSFEPGVAVRLLRNPNYHKPGLPHF
DEVEFIAIPDRSARLNALLTGEVDVIEDVDIRNVPLIERNPDLVLHRTPSLRHLTFDMNCQTAPFDNPVVRKALKLSLDR
EDVIAKVFLGEAETGNDNPVARIMPFWAETPPEHRYDPEAARALLAEAGIEGLTVDLSVAESAFPGAVEAGVLFREHAAK
AGITINLVQEADDGYWDNVWLVKPFNAADWYGRVTLDWLFATSYTSDAPWNNTGFKNARFDELHAAARSETDPATRGEQY
AEMQQILHDDGGVITVAFVSWLLAMSRAIGHGETGGILPADNHRCAERWWRTDV

Sequences:

>Translated_534_residues
MRYPTGPIGGQILAQAMSLAPSRRAFLGGAAAVAGAFCLPASLRAEEGPKRGGRLRYGVNDGSQQDSLEPGSWATVMCGA
AFNGALCNNLVELLPDGSLAGDLAESWEEAEGATRWTFTLRKGVLFHDGRPFTPEDARQSLMHHMGEGSTSGALAIVSQI
KEIAVEGEDRLIVTLTQGNADFPYLLSDYHLSIFPAKEGGGIDWESGIGTGAFKLDSFEPGVAVRLLRNPNYHKPGLPHF
DEVEFIAIPDRSARLNALLTGEVDVIEDVDIRNVPLIERNPDLVLHRTPSLRHLTFDMNCQTAPFDNPVVRKALKLSLDR
EDVIAKVFLGEAETGNDNPVARIMPFWAETPPEHRYDPEAARALLAEAGIEGLTVDLSVAESAFPGAVEAGVLFREHAAK
AGITINLVQEADDGYWDNVWLVKPFNAADWYGRVTLDWLFATSYTSDAPWNNTGFKNARFDELHAAARSETDPATRGEQY
AEMQQILHDDGGVITVAFVSWLLAMSRAIGHGETGGILPADNHRCAERWWRTDV
>Mature_534_residues
MRYPTGPIGGQILAQAMSLAPSRRAFLGGAAAVAGAFCLPASLRAEEGPKRGGRLRYGVNDGSQQDSLEPGSWATVMCGA
AFNGALCNNLVELLPDGSLAGDLAESWEEAEGATRWTFTLRKGVLFHDGRPFTPEDARQSLMHHMGEGSTSGALAIVSQI
KEIAVEGEDRLIVTLTQGNADFPYLLSDYHLSIFPAKEGGGIDWESGIGTGAFKLDSFEPGVAVRLLRNPNYHKPGLPHF
DEVEFIAIPDRSARLNALLTGEVDVIEDVDIRNVPLIERNPDLVLHRTPSLRHLTFDMNCQTAPFDNPVVRKALKLSLDR
EDVIAKVFLGEAETGNDNPVARIMPFWAETPPEHRYDPEAARALLAEAGIEGLTVDLSVAESAFPGAVEAGVLFREHAAK
AGITINLVQEADDGYWDNVWLVKPFNAADWYGRVTLDWLFATSYTSDAPWNNTGFKNARFDELHAAARSETDPATRGEQY
AEMQQILHDDGGVITVAFVSWLLAMSRAIGHGETGGILPADNHRCAERWWRTDV

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=458, Percent_Identity=25.9825327510917, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787052, Length=449, Percent_Identity=25.6124721603563, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1787495, Length=530, Percent_Identity=26.2264150943396, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787762, Length=442, Percent_Identity=24.4343891402715, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789887, Length=295, Percent_Identity=27.1186440677966, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787551, Length=479, Percent_Identity=23.5908141962422, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789397, Length=477, Percent_Identity=24.3186582809224, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 58198; Mature: 58198

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYPTGPIGGQILAQAMSLAPSRRAFLGGAAAVAGAFCLPASLRAEEGPKRGGRLRYGVN
CCCCCCCCCHHHHHHHHHCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCC
DGSQQDSLEPGSWATVMCGAAFNGALCNNLVELLPDGSLAGDLAESWEEAEGATRWTFTL
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEE
RKGVLFHDGRPFTPEDARQSLMHHMGEGSTSGALAIVSQIKEIAVEGEDRLIVTLTQGNA
ECCEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
DFPYLLSDYHLSIFPAKEGGGIDWESGIGTGAFKLDSFEPGVAVRLLRNPNYHKPGLPHF
CCCEEEECCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCC
DEVEFIAIPDRSARLNALLTGEVDVIEDVDIRNVPLIERNPDLVLHRTPSLRHLTFDMNC
CCEEEEEECCCCCEEEEEEECCEEEEECCCCCCCCEEECCCCEEEECCCCCEEEEEECCC
QTAPFDNPVVRKALKLSLDREDVIAKVFLGEAETGNDNPVARIMPFWAETPPEHRYDPEA
CCCCCCCHHHHHHHHHCCCHHHHEEHHEECCCCCCCCCCCEEEEEHHCCCCCCCCCCHHH
ARALLAEAGIEGLTVDLSVAESAFPGAVEAGVLFREHAAKAGITINLVQEADDGYWDNVW
HHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEE
LVKPFNAADWYGRVTLDWLFATSYTSDAPWNNTGFKNARFDELHAAARSETDPATRGEQY
EEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHH
AEMQQILHDDGGVITVAFVSWLLAMSRAIGHGETGGILPADNHRCAERWWRTDV
HHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MRYPTGPIGGQILAQAMSLAPSRRAFLGGAAAVAGAFCLPASLRAEEGPKRGGRLRYGVN
CCCCCCCCCHHHHHHHHHCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCC
DGSQQDSLEPGSWATVMCGAAFNGALCNNLVELLPDGSLAGDLAESWEEAEGATRWTFTL
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEE
RKGVLFHDGRPFTPEDARQSLMHHMGEGSTSGALAIVSQIKEIAVEGEDRLIVTLTQGNA
ECCEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
DFPYLLSDYHLSIFPAKEGGGIDWESGIGTGAFKLDSFEPGVAVRLLRNPNYHKPGLPHF
CCCEEEECCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCC
DEVEFIAIPDRSARLNALLTGEVDVIEDVDIRNVPLIERNPDLVLHRTPSLRHLTFDMNC
CCEEEEEECCCCCEEEEEEECCEEEEECCCCCCCCEEECCCCEEEECCCCCEEEEEECCC
QTAPFDNPVVRKALKLSLDREDVIAKVFLGEAETGNDNPVARIMPFWAETPPEHRYDPEA
CCCCCCCHHHHHHHHHCCCHHHHEEHHEECCCCCCCCCCCEEEEEHHCCCCCCCCCCHHH
ARALLAEAGIEGLTVDLSVAESAFPGAVEAGVLFREHAAKAGITINLVQEADDGYWDNVW
HHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEE
LVKPFNAADWYGRVTLDWLFATSYTSDAPWNNTGFKNARFDELHAAARSETDPATRGEQY
EEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHH
AEMQQILHDDGGVITVAFVSWLLAMSRAIGHGETGGILPADNHRCAERWWRTDV
HHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]